<p>A Novel Prognostic Scoring Model Based on Albumin and γ-Glutamyltransferase for Hepatocellular Carcinoma Prognosis</p>

Abstract

These authors contributed equally to this work Aim: To investigate the predictive value of albumin (ALB) and γ-glutamyltransferase (GGT) in hepatocellular carcinoma (HCC) patients undergoing curative resection. We sought to establish a new scoring model for predicting the prognosis of HCC patients undergoing curative resection. Patients and methods: A retrospective analysis was performed in 303 HCC patients who underwent curative resection. Preoperative risk factors for survival were investigated using univariate and multivariate analyses. On the basis of significant factors, a prognostic scoring model was established. The overall survival (OS) and recurrence-free survival (RFS) were compared between different groups. Results: Multivariate Cox regression showed that preoperative decreased ALB levels and elevated GGT levels were significantly associated with poor OS and RFS. Multivariate analysis showed that ALB level, GGT level, portal vein tumor thrombus, and tumor number were independent prognostic factors for both OS and RFS. Thereafter, we established a preoperative prognostic scoring model combining the four risk factors. The results revealed that higher risk scores might mean worse OS and RFS. Conclusion: Preoperative ALB and GGT levels are potentially useful biomarkers for predicting the prognostic outcomes in HCC patients undergoing curative resection. Our new prognostic scoring model qualifies as a novel prognostic predictor for HCC patients after curative resection.

Albumin-to-alkaline phosphatase ratio as a predictor of tumor recurrence and prognosis in patients with early-stage hepatocellular carcinoma undergoing radiofrequency ablation as initial therapy

“…Moreover, AKP is also found to be correlated with epithelial mesenchymal transition phenotypes in HCC; epithelial mesenchymal transition is considered to be a major step in tumor invasion or metastasis [28,29]. Furthermore, ALB is conventionally considered as an indicator of nutritional status, and low levels of ALB indicate a dysfunction of protein synthesis in the liver [31], which may eventually impair immunity. In addition, emerging evidence has revealed that ALB can stabilize cell growth, exert antioxidant effects against carcinogens, and suppress tumor cell proliferation by reducing the phosphorylation of Rb proteins [30].…”

Serum levels of gamma-glutamyl transpeptidase in relation to HCC human biology and prognosis

“…However, there is a recent increase in its consideration as a practical marker [19][20][21], especially for that group of almost 50% of HCC patients who do not have elevated AFP [22][23][24][25]. Furthermore, there have been several other reports of the usefulness of GGT in combination with other markers [26][27][28][29][30][31], as well as a metaanalysis [32]. Of particular note in our analysis, was the usefulness of combination GGT plus albumin in the low-AFP cohort, for whom there are few other validated tumor markers (Tables 11 and 12).…”

Uncovering the Mechanism of the Effects of Pien-Tze-Huang on Liver Cancer Using Network Pharmacology and Molecular Docking

“…Peng et al found that ALB is a biomarker, which is related to the early diagnosis, metastasis, prognosis, or treatment of HCC [ 50 ]. The levels of ALB and GGT before operation are potential biomarkers to predict the prognosis of patients with liver cancer undergoing radical resection [ 51 ]. The evaluation of liver fibrosis degree is an important basis for the clinical diagnosis and treatment of HCC.…”