<p>A Preliminary Clinical Evaluation of a Topical Product for Reducing Slight Rosacea Imperfections</p>

Abstract

Introduction: Rosacea is a chronic multifactorial skin disorder mainly affecting facial skin with an estimated prevalence of about 5% worldwide. Its main symptoms, occurring early during pathology development, are skin dehydration, redness, erythema, and telangiectasia. Given the lack of a resolutive cure, therapeutic approaches able to relieve the main symptoms are needed. Purpose: The aim of this research article is to evaluate the beneficial effect of a topical product (Serum BK46) on rosacea symptoms. Patients and Methods: A monocentric single-arm, non-blinded study was performed to assess the clinical effect of Serum BK46 in relieving the main symptoms of rosacea: skin dryness, increased trans epidermal water loss (TEWL), redness, and abnormal vascularization. Twenty patients with mild to moderate rosacea were enrolled in the study and asked to apply the product twice per day for 56 days. Skin moisturization, TEWL, and erythema index were instrumentally assessed at baseline and following 24 h and 14, 28 and 56 days of treatment. Clinical parameters, including redness and telangiectasia imperfection visibility, were evaluated on a 5-point scale by a specialized dermatologist at baseline and after 14, 28, and 56 days of treatment. Finally, the visibility of vessel diameter was evaluated at baseline and after 28 and 56 days of treatment. Results: Serum BK46 application restored skin hydration and prevented the loss of water by the skin. Long-term treatment with Serum BK46 significantly reduced skin redness, erythema index, and the visibility of telangiectasia imperfections and superficial vessels. The investigated product's clinical effect was demonstrated by both instrumental and clinical evaluation. Furthermore, Serum BK46 was completely tolerated and no adverse effects were recorded. Conclusion: The moisturizing and skin barrier restoring action of Serum BK46 has been clearly proven in patients displaying mild to moderate rosacea; thus, this product is a good candidate for rosacea treatment.

Skin barrier response to active chlorine hand disinfectant—An experimental study comparing skin barrier response to active chlorine hand disinfectant and alcohol‐based hand rub on healthy skin and eczematous skin

“…The evaporimetry skin barrier measurement, TEWL, is validated and hence the best method for evaluation of skin barrier damage, 32 and the utility of the tool is confirmed by the continuous use of TEWL over decades as the primary outcome in several experimental studies evaluating the skin barrier response to for example SLS, ABHR, detergents, and topical products. 8,46 Numerous studies have shown that the skin barrier evaluated by TEWL after application of ABHR is unaffected as in accordance with our results. 6,8,9 However, Plum et al reported an increase in TEWL when the ABHR was applied on hydrated skin, which may mimic the real-life situation in busy work-settings in the health care sector.…”

“…have shown that the TEWL values were stable between 1 and 3 h after removal of patches 45 the measurements in our study were performed 1 h after patch removal. The evaporimetry skin barrier measurement, TEWL, is validated and hence the best method for evaluation of skin barrier damage, 32 and the utility of the tool is confirmed by the continuous use of TEWL over decades as the primary outcome in several experimental studies evaluating the skin barrier response to for example SLS, ABHR, detergents, and topical products 8,46 …”

Preparation, Characterization and Permeation Study of Topical Gel Loaded with Transfersomes Containing Asiatic Acid

“…Polyacrylate crosspolymer-6 is also pre-neutralized synthetic polymer acting as a gelling and stabilizing agent. This component could deposit over the outer layers of the skin because of its high molecular weight and thereby facilitate the formation of a barrier to prevent water loss and hydrate the skin [ 35 ]. The silicone-based emulsifier (dimethicone-based emulsifier) was used in the formulations as a texture and sensory modifier.…”

Use of Botulinum Toxin in Treating Rosacea: A Systematic Review

“…Rosacea is a chronic skin disorder characterized by erythema, flushing, telangiectasia, papules and pustules, phymatous changes, and ocular involvement. [1][2][3][4][5] In 2012, a standard classification system for rosacea was developed by the National Rosacea Society Expert Committee. Four distinct subtypes of rosacea were established: erythematotelangiectatic, papulopustular, phymatous, and ocular rosacea.…”