&lt;p&gt;An anti-inflammatory peptide and brain-derived neurotrophic factor-modified hyaluronan-methylcellulose hydrogel promotes nerve regeneration in rats with spinal cord injury&lt;/p&gt;

He, Zhaoyi; Zang, Hongxin; Zhu, Lei; Huang, Kui; Yi, Tailong; Zhang, Sai; Cheng, Shixiang

doi:10.2147/ijn.s187854

Cited by 81 publications

(49 citation statements)

References 47 publications

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“…Considering the scaffold implantation in this study and meeting the above conditions, the transection model may be an appropriate model for the study of biomaterial scaffolds for SCI repair. In some studies, aneurysm clips were used to establish SCI model, and hydrogel was injected into the injury site after SCI [ 41 ]. The location choice of the injury between T9 and T10 should also be motivated.…”

Section: Discussionmentioning

confidence: 99%

The corticospinal tract structure of collagen/silk fibroin scaffold implants using 3D printing promotes functional recovery after complete spinal cord transection in rats

Zhu

Liu

et al. 2021

J Mater Sci: Mater Med

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No effective treatment has been established for nerve dysfunction caused by spinal cord injury (SCI). Orderly axonal growth at the site of spinal cord transection and creation of an appropriate biological microenvironment are important for functional recovery. To axially guiding axonal growth, designing a collagen/silk fibroin scaffold fabricated with 3D printing technology (3D-C/SF) emulated the corticospinal tract. The normal collagen/silk fibroin scaffold with freeze-drying technology (C/SF) or 3D-C/SF scaffold were implanted into rats with completely transected SCI to evaluate its effect on nerve repair during an 8-week observation period. Electrophysiological analysis and locomotor performance showed that the 3D-C/SF implants contributed to significant improvements in the neurogolical function of rats compared to C/SF group. By magnetic resonance imaging, 3D-C/SF implants promoted a striking degree of axonal regeneration and connection between the proximal and distal SCI sites. Compared with C/SF group, rats with 3D-C/SF scaffold exhibited fewer lesions and disordered structures in histological analysis and more GAP43-positive profiles at the lesion site. The above results indicated that the corticospinal tract structure of 3D printing collagen/silk fibroin scaffold improved axonal regeneration and promoted orderly connections within the neural network, which could provided a promising and innovative approach for tissue repair after SCI.

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Section: Discussionmentioning

confidence: 99%

The corticospinal tract structure of collagen/silk fibroin scaffold implants using 3D printing promotes functional recovery after complete spinal cord transection in rats

Zhu

Liu

et al. 2021

J Mater Sci: Mater Med

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“…An anti-in ammatory combined neuroprotection strategy is one of the most promising options for the treatment of SCI [8,32]. Activation of microglia is one of the earliest in ammatory reactions after injury, and this activation is usually excessive [33].…”

Section: Discussionmentioning

confidence: 99%

Engineered Exosomes Derived From Primary M2 Macrophages With Anti-inflammatory And Neuroprotective Properties For The Treatment of Spinal Cord Injury.

Zhang

et al. 2021

Preprint

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Background: Uncontrollable inflammation and nerve cell apoptosis are the most destructive pathological response after spinal cord injury (SCI). So, inflammation suppression combined with neuroprotection is one of the most promising strategies to treat SCI. Engineered exosomes with anti-inflammatory and neuroprotective properties are promising candidates for the implementation of this strategies for the treatment of SCI. Results: By combining nerve growth factor (NGF) and curcumin (Cur), we prepared stable engineered exosomes of approximately 120 nm from primary M2 macrophages with anti-inflammatory and neuroprotective properties (Cur@EXs-cl-NGF). Notably, NGF was coupled with EXs by matrix metalloproteinase 9 (MMP9)-cleavable linker to accurately release at the injured site. Through targeted experiments, we found that these exosomes could actively and effectively accumulate at the injured site of SCI mice, which greatly improved the bioavailability of the drugs. Subsequently, Cur@EXs-cl-NGF reached the injured site and could effectively inhibit the uncontrollable inflammatory response to protect the spinal cord from secondary damage; in addition, Cur@EXs-cl-NGF could release NGF into the microenvironment in time to exert a neuroprotective effect against nerve cell damage. Conclusions: A series of in vivo and in vitro experiments showed that the engineered exosomes significantly improved the microenvironment after injury and promoted the recovery of motor function after SCI. We provide a new method for inflammation suppression combined with neuroprotective strategies to treat SCI.

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“…Yan Sun et al indicated that exercise can ameliorate SCI damage through NF-κB signaling pathways 22. Several studies have also indicated that inhibition of inflammation can improve axonal regeneration 23, 24. In the present study, as the evidence is not clear yet in regards to the direct relationship between congenital exercise ability and inflammation, fibrosis, or demyelination.…”

Section: Discussionmentioning

confidence: 99%

Congenital exercise ability ameliorates muscle atrophy but not spinal cord recovery in spinal cord injury mouse model

et al. 2019

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Spinal cord injury (SCI) can cause loss of mobility in the limbs, and no drugs, surgical procedures, or rehabilitation strategies provide a complete cure. Exercise capacity is thought to be associated with the causes of many diseases. However, no studies to date have assessed whether congenital exercise ability is related to the recovery of spinal cord injury. High congenital exercise ability (HE) and low congenital exercise ability (LE) mice were artificially bred from the same founder ICR mice. The HE and LE groups still exhibited differences in exercise ability after 13 generations of breeding. Histological staining and immunohistochemistry staining indicated no significant differences between the HE and LE groups on recovery of the spinal cord. In contrast, after SCI, the HE group exhibited better mobility in gait analysis and longer endurance times in the exhaustive swimming test than the LE group. In addition, after SCI, the HE group also exhibited less atrophy than the LE group, and no inflammatory cells appeared. In conclusion, we found that high congenital exercise ability may reduce the rate of muscle atrophy. This result can be applied to sports science and rehabilitation science as a reference for preventive medicine research.

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<p>An anti-inflammatory peptide and brain-derived neurotrophic factor-modified hyaluronan-methylcellulose hydrogel promotes nerve regeneration in rats with spinal cord injury</p>

Cited by 81 publications

References 47 publications

The corticospinal tract structure of collagen/silk fibroin scaffold implants using 3D printing promotes functional recovery after complete spinal cord transection in rats

The corticospinal tract structure of collagen/silk fibroin scaffold implants using 3D printing promotes functional recovery after complete spinal cord transection in rats

Engineered Exosomes Derived From Primary M2 Macrophages With Anti-inflammatory And Neuroprotective Properties For The Treatment of Spinal Cord Injury.

Congenital exercise ability ameliorates muscle atrophy but not spinal cord recovery in spinal cord injury mouse model

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