<p>Anlotinib is effective in the treatment of advanced carcinoma ex pleomorphic adenoma of the submandibular gland</p>

Abstract

Background: Carcinoma ex pleomorphic adenoma (CXPA), a very rare malignancy found mostly in the major salivary glands, has no established standardized treatment. Case presentation: This report describes a 67-year-old male with advanced CXPA who was effectively treated by anlotinib. Pleomorphic adenoma of the submandibular gland was first diagnosed in 1976 after a surgical resection of a mass underneath the jaw. The patient underwent re-excision 3 years later due to a recurrent pleomorphic adenoma. CXPA was first diagnosed in 2016 after a surgical removal of the left submandibular mass. A lung nodule was found on a chest CT scan in January 2018. Following a CT-guided lung biopsy that demonstrated findings consistent with pulmonary metastasis, the patient underwent local therapy (microwave ablation and radioactive seed implantation) but suffered a recurrence of disease approximately 6 months later. Anlotinib was administered orally at a dose of 12 mg daily on a 2 weeks on/1 week off schedule. A partial response was observed after two cycles of treatment. The disease remains in continued partial response after completion of his sixth cycle. Conclusion: This is the first report for anlotinib in treating CXPA. Further pre-clinical and clinical studies are needed to validate the efficacy and safety of anlotinib in the treatment of CXPA.

The summary and preliminary analysis of clinical and PET/CT features of patients with intestinal metastasis of primary lung cancer

“…TTF-1, CDX-2, CK7, and CK20 Immunohistochemistry helps identify cancer cells' tissue origin. Primary lung adenocarcinoma was positive for TTF-1, NapsinA, CK7, CK8, CK18 (24)(25)(26). Primary lung squamous cell carcinoma was positive for P40, P63, and CK5/6(26).…”

Carcinoma ex pleomorphic adenoma of the submandibular gland: A retrospective analysis of 86 patients

“…The management of SMG‐CXPA includes an ablative surgical procedure, postoperative radiotherapy or chemotherapy (Iino et al, 2008; Song et al, 2019). Among these modalities, neck dissection is an important part of surgical treatment.…”

Efficacy of Immunotherapy Combined with Antiangiogenic Therapy in Treatment-Failure Patients with Advanced Carcinoma Ex Pleomorphic Adenoma of the Submandibular Gland: A Case Report

“…Soares et al [ 8 ] reported a gradual but significant increase in angiogenesis during the transformation from PA to the extensively aggressive Ca ex PA. Fonseca et al [ 10 ] found that VEGF expression was significantly high in malignant salivary gland tumors compared to benign tumors, suggesting that VEGF is involved in the pathogenesis and aggression of salivary gland tumors. These findings implied that inhibition of the VEGF signaling pathway is a potential treatment approach for Ca ex PA. Song et al [ 11 ] reported a patient with advanced Ca ex PA who achieved partial response after anlotinib monotherapy. However, in the current case, the patient suffered disease progression after 50 days of single-agent anlotinib treatment.…”