<p>Anterior chamber angle in aniridia with and without glaucoma</p>

Abstract

Purpose We performed a retrospective, comparative study to determine if patients with aniridia and glaucoma had open angles on high-resolution anterior segment optical coherence tomography (OCT) and clinical gonioscopy. Patients and methods Forty-three patients (86 eyes) with aniridia had recorded anterior segment OCTs, gonioscopy, or both. Of these patients, 27 (54 eyes) were diagnosed with glaucoma and 16 (32 eyes) had no evidence of glaucoma. All patients had either anterior segment OCT, gonioscopy, or both. Results The 43 patients with aniridia had average age of 32±17 years, and 27 (62%) were female. Anterior segment OCT and gonioscopy were recorded in 25 (58%) of the patients and 18 (42%) of the patients had gonioscopy alone. Of the 54 eyes with aniridia and glaucoma, 4 (7%) eyes in 3 patients (11%) had partial or completely closed angles. Of the 32 eyes without glaucoma, all (100%) had open angles. The proportion of open angles in the aniridia with glaucoma eyes was not significantly different compared with the aniridia without glaucoma eyes ( P =0.32). Of the 4 eyes with closed angles, all had a history of prior surgery for cataract, glaucoma, and/or keratopathy. The proportion of eyes with prior surgery was significantly higher in eyes with open-angle glaucoma and angle-closure glaucoma compared with eyes without glaucoma ( P <0.001 and P =0.002, respectively). Conclusion The majority of eyes with aniridia and glaucoma have open anterior chamber angles, similar to patients with aniridia without glaucoma. All eyes with aniridia and glaucoma that had closed angles had a prior history of ocular surgery.

Anterior Segment Optical Coherence Tomography in Pediatric Ocular Pathology: Imaging Study of 115 eyes

“…We have even been able to image emulsified silicon oil droplets in the AC, subconjunctivally and adherent to the anterior lens capsule. Bajwa et al 20 have studied aniridia with this technique in 43 patients, some of them were children. Ahmed 21 et al have utilized this technique in 9 children with mucopolysaccharidoses and found it useful to predict glaucoma risk, and also observed crowded anterior segments and thick corneas in these.…”

The Genetic and Endoplasmic Reticulum-Mediated Molecular Mechanisms of Primary Open-Angle Glaucoma

“…There are several research data confirming a direct correlation of PAX6 gene mutation with aniridia occurrence [181][182][183][184]. Interestingly, it has been reported that aniridia is frequently correlated with glaucoma and glaucoma associated with aniridia may trigger a progressive loss of vision [185]. Netland et al have reported that, in 46% individuals, out of 83 aniridia subjects, glaucoma has been identified [186].…”

Congenital aniridia with ectopia lentis and unilateral buphthalmos: an unusual presentation

“…Other recognised mechanisms are progressive angle closure with peripheral anterior synechiae and aniridia fibrosis syndrome secondary to intraocular surgeries. [4][5][6][7][8] Congenital glaucoma associated with or without buphthalmos is rare in aniridia. [5][6][7] The ocular phenotype can vary between and within families in aniridia, but affected individuals usually have similarity between the two eyes.…”

“…[4][5][6][7][8] Congenital glaucoma associated with or without buphthalmos is rare in aniridia. [5][6][7] The ocular phenotype can vary between and within families in aniridia, but affected individuals usually have similarity between the two eyes. 1 Asymmetry of ocular phenotype is not a rarity in syndromic cases and has been reported in the literature.…”