<p>Antiangiogenic properties of nanoparticles: a systematic review</p>

Abstract

Nanoparticles appear to be one of the most promising agents that offer efficacy in angiogenesis-related disease therapy. The objective of this research is to systematically review studies that have probed into the effect of nanoparticles on angiogenesis. Selected inclusion criteria were used to extract articles, references that were cited in the initial search were sought to identify more potential articles, and articles that did not meet the inclusion criteria and duplicates were discarded. The spherical shape was shown to be the most common shape employed to investigate the role of nanoparticles in angiogenesis therapy. The size of nanoparticles appears to play a crucial role for efficacy on angiogenesis, in which 20 nm emerged as the preferred size. Gold nanoparticles exhibit the most promise as an antiangiogenesis agent, and the toxicity was adjustable based on the dosages applied.

Microbe‐Mediated Extracellular and Intracellular Mineralization: Environmental, Industrial, and Biotechnological Applications

“…Angiogenesis plays a critical role in tumor growth and metastasis. [ 344 ] Apart from their antibacterial properties, AgNPs synthesized by microbes possess antiangiogenic properties [ 345 ] and are cytotoxic against tumor cells by impairing mitochondria, blocking cell cycle, and activating apoptosis ( Figure A). [ 346 ] For example, AgNPs synthesized by the extremophilic, radiation‐resistant bacterium Deinococcus radiodurans are capable of inhibiting tumor cells from the mammalian breast cancer cell line MCF‐7.…”

Tailored Gold Nanoparticles for Cancer Imaging and Therapy

“…The concept of theranostics with multifunctional AuNPs has a great potential to enhance the medical area towards personalized medicine [90]. Also, another new dimension in the field of medicine refers to the AuNPs used as antiangiogenic agents in cancer therapy [91,92].…”

Tumor Angiogenesis and Anti-Angiogenic Strategies for Cancer Treatment

“…Examples of the intensively studied nanoparticles employed for the delivery of anti-angiogenic agents include cerium oxide, gold, silver, copper, silicate and silica-based, carbon-based, chitosan, and peptide-conjugated nanoparticles [153]. As it has been proven that nanoparticles properties, such as size and shape, directly influence angiogenesis processes within tumors, the fabrication process is essential for the outcome of the treatment [155].…”