&lt;p&gt;Antidepressant, anti-inflammatory, and antioxidant effects of electroacupuncture through sonic hedgehog–signaling pathway in a rat model of poststroke depression&lt;/p&gt;

Cai, Wa; Ma, Wen; Wang, Guan-Tao; Li, Yijing; Shen, Wei-Dong

doi:10.2147/ndt.s205033

Cited by 32 publications

(21 citation statements)

References 48 publications

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“…Of these studies, 11 assessed the effect of EA on depression-related behavior, including performance in the forced swim test (FST), open-field test (OFT), Morris water maze (MWM) test, and sucrose preference test (SPT), and body weight [ 20 , 21 , 23 , 24 , 27 , 29 , 34 , 42 – 45 ]. Four other studies assessed changes in neuropeptides and neurotransmitters, including the protein and mRNA expression of galanin (Gal) and tryptophan hydroxylase (TPH), and serotonin (5-HT) levels [ 21 , 25 , 30 , 45 ]. Three additional studies assessed changes in hippocampal synaptic plasticity [ 21 , 22 , 35 ].…”

Section: Resultsmentioning

confidence: 99%

“…Moreover, 2 studies assessed changes in proinflammatory cytokine levels [ 26 , 40 ], and 2 studies assessed changes in the hypothalamic-pituitary-adrenal (HPA) axis [ 26 , 40 ]. Three other studies assessed changes in BDNF levels [ 27 , 36 , 46 ], while 6 studies evaluated the effects of EA on signaling pathways, including the AC-cAMP-PKA, Shh, extracellular regulated protein kinase (ERK), and mitogen-activated protein kinase (MAPK) signaling pathways, and dopaminergic synapses [ 28 , 31 , 32 , 39 , 41 , 45 ]. The final 2 studies investigated changes in the expression of multiple genes after EA therapy in depressed rats [ 37 , 47 ].…”

Section: Resultsmentioning

confidence: 99%

“…To determine the mechanism of EA in depression, 6 studies assessed the levels of signaling pathway-related factors that were imbalanced during depression and were subsequently normalized after EA treatment. Cai et al [ 45 ] found that EA effectively resisted the effects of oxidation by reducing malondialdehyde (MDA) levels and increasing glutathione (GSH) levels in PSD rats. EA also reduced the levels of inflammatory cytokines, including IL6, TNFα, and IL1β.…”

Section: Discussionmentioning

confidence: 99%

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The mechanism of electroacupuncture for depression on basic research: a systematic review

et al. 2021

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Background Electroacupuncture (EA) is generally accepted as a safe and harmless treatment option for alleviating depression. However, there are several challenges related to the use of EA. Although EA has been shown to be effective in treating depression, the molecular mechanism is unclear. Objective To reveal the therapeutic effect of EA and its possible mechanism in the treatment of depression. Search strategy We performed a systematic search according to PRISMA guidelines. We electronically searched PubMed, Web of Science (WOS), the China National Knowledge Infrastructure (CNKI), Wanfang Data Information Site and the VIP information database for animal studies in English published from the inception of these databases to December 31, 2019. Inclusion criteria Electronic searches of PubMed, WOS, the CNKI, Wanfang and the VIP database were conducted using the following search terms: (depression OR depressive disorder OR antidepressive), (rat OR mouse) AND (acupuncture OR EA). Data extraction and analysis The data were extracted primarily by one author, and a follow-up review was conducted by the other authors. Results Twenty-eight articles met the inclusion criteria. The most commonly used method for inducing depression in animal models was 21 days of chronic unpredictable mild stress. For the depression model, the most commonly selected EA frequency was 2 Hz. Among the 28 selected studies, 11 studies observed depression-related behaviors and used them as indicators of EA efficacy. The other 17 studies focused on mechanisms and assessed the indexes that exhibited abnormalities that were known to result from depression and then returned to a normal range after EA treatment. Treatment of depression by EA involves multiple therapeutic mechanisms, including inhibition of HPA axis hyperactivity and inflammation, regulation of neuropeptides and neurotransmitters, modulation of the expression of particular genes, restoration of hippocampal synaptic plasticity, increased expression of BDNF, and regulation of several signaling pathways. Conclusions This review reveals that the mechanisms underlying the effect of acupuncture involve multiple pathways and targets, suggesting that acupuncture is a wholistic treatment for people rather than for diseases. Our findings also explain why acupuncture can treat various disorders in addition to depression.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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The mechanism of electroacupuncture for depression on basic research: a systematic review

et al. 2021

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“…EA therapy can significantly decrease the content of lipid peroxidation end-product malondialdehye (MDA) and 4-hydroxynonenal (4-HNE) in cerebral I/R injury rats [ 60 – 62 ], possibly via increasing the activities of antioxidative enzymes, namely GSH-Px and SOD [ 63 – 66 ]. In addition, the ginger pharma acupuncture or laser acupuncture can significantly reduce MDA production in the cerebral cortex and hippocampus while increasing catalase, GSH-Px, and SOD simultaneously [ 67 , 68 ].…”

Section: Acupuncture Regulates Oxidative Stress In Ischemic Strokementioning

confidence: 99%

Mechanisms of Acupuncture in the Regulation of Oxidative Stress in Treating Ischemic Stroke

Wang

et al. 2020

Oxidative Medicine and Cellular Longevity

122

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Ischemic stroke is the major type of cerebrovascular disease usually resulting in death or disability among the aging population globally. Oxidative stress has been closely linked with ischemic stroke. Disequilibrium between excessive production of reactive oxygen species (ROS) and inherent antioxidant capacity leads to subsequent oxidative damage in the pathological progression of ischemic brain injury. Acupuncture has been applied widely in treating cerebrovascular diseases from time immemorial in China. This review mainly lays stress on the evidence to illuminate the possible mechanisms of acupuncture therapy in treating ischemic stroke through regulating oxidative stress. We found that by regulating a battery of molecular signaling pathways involved in redox modulation, acupuncture not only activates the inherent antioxidant enzyme system but also inhibits the excessive generation of ROS. Acupuncture therapy possesses the potential in alleviating oxidative stress caused by cerebral ischemia, which may be linked with the neuroprotective effect of acupuncture.

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“…Studies have shown that electroacupuncture (EA) treatment is effective for post‐stroke depression (PSD). The mechanism of EA to treat PSD is to suppress inflammation and oxidative stress through activation of the Shh‐signalling pathway 103 . Studies have shown that naringenin via Sonic hedgehog‐Gli1 cell signalling pathway has antidepressant and neuroprotective effects 104 .…”

Section: Effect Of Shh Signal Pathway On Cnsmentioning

confidence: 99%

The role of Shh signalling pathway in central nervous system development and related diseases

et al. 2020

Cell Biochemistry & Function

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Sonic hedgehog (Shh) plays important roles in developmental of vertebrate animal central nervous system (CNS), and Gli is its downstream signal molecule. Shh signalling is essential for pattern formation, cell‐fate specification, axon guidance, proliferation, survival and differentiation of neurons in CNS development. The abnormal signalling pathway of Shh leads to the occurrence of many nervous system diseases. The mechanism of Shh signalling is complex and remains incompletely understood. Nevertheless, studies have revealed that Shh signalling pathway is classified into canonical and non‐canonical pathways. Here we review the role of the Shh signalling pathway and its impact in CNS development and related diseases. Specifically, we discuss the role of Shh in the spinal cord and brain development, cell differentiation and proliferation in CNS and related diseases such as brain tumour, Parkinson's diseases, epilepsy, autism, depression and traumatic brain injury. We also highlight future directions of research that could help to clarify the mechanisms and consequences of Shh signalling in the process of CNS development and related diseases. Significance of the study This review summarized the role of Shh signalling pathway in CNS development and related diseases such as brain tumour, Parkinson's diseases, epilepsy, autism, depression and traumatic brain injury. It also presented the author's opinions on the future research direction of Shh signalling pathway.

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<p>Antidepressant, anti-inflammatory, and antioxidant effects of electroacupuncture through sonic hedgehog–signaling pathway in a rat model of poststroke depression</p>

Cited by 32 publications

References 48 publications

The mechanism of electroacupuncture for depression on basic research: a systematic review

The mechanism of electroacupuncture for depression on basic research: a systematic review

Mechanisms of Acupuncture in the Regulation of Oxidative Stress in Treating Ischemic Stroke

The role of Shh signalling pathway in central nervous system development and related diseases

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