&lt;p&gt;Antioxidant and toxicity studies of biosynthesized cerium oxide nanoparticles in rats&lt;/p&gt;

Khorrami, Mohammad Bagher; Sadeghnia, Hamid Reza; Pasdar, Alireza; Ghayour‐Mobarhan, Majid; Riahi-Zanjani, Bamdad; Hashemzadeh, Alireza; Zare, Mohammad Hosein; Darroudi, Majid

doi:10.2147/ijn.s194192

Cited by 51 publications

(28 citation statements)

References 57 publications

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“…There are many different studies that have con rmed the antioxidant properties of CeONPs in different tissues and in serum [39][40][41]. In a study by Kim et al in 2017, they showed under conditions similar to our experiment, that injection of the same amount of CeONPs could reduce the ROS levels at the lesion site after SCI.…”

Section: Discussionsupporting

confidence: 80%

Injection of Cerium Oxide Nanoparticles To Treat Spinal Cord Injury In Rats

Behroozi

Rahimi

Hamblin

et al. 2021

Preprint

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Introduction: The present study, investigated the local injection of cerium oxide nanoparticles (CeONPs) into Spinal cord injury (SCI) lesions in rats, and the effect on motor performance and neuropathic pain, together with biochemical markers.Methods: 36 adult male Wistar rats were divided into 4 groups: control group (healthy animals); sham group (laminectomy); SCI group (laminectomy+SCI induction); treatment group (laminectomy + SCI induction + intrathecal injection of 10 µL of CeONPs (1000 µg/mL) immediately after injury). SCI was induced by application of an aneurysm clip at the T12-T13 vertebral region. Immediately after SCI, CeONPs were injected into the treatment group with a Hamilton syringe and micropipet. H&E staining and measurement of the size of the cavity were performed after 6 weeks, and the BBB motor performance test and pain threshold test were performed weekly. GCSF expression, P44/42 MAPK (ERK1/ERK2), P-P44/42 MAPK (ERK1/ERK2), total Tau, total MAG, β-actin were evaluated after 6 weeks.Results: The BBB score and pain threshold improved in animals receiving CeONPs compared with SCI animals. The size of the cavity decreased in the treatment group. GCSF protein expression levels were similar in animals receiving CeONPs compared with the SCI group, but the expression of ERK1/ERK2 and phospho-ERK was lower compared with the SCI group. The expression levels of Tau and MAG were significantly increased in treated animals compared to the SCI group.Conclusion: The use of CeONPs in SCI could improve motor functional recovery, reduce pain and increase nerve cell regeneration.

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Section: Discussionsupporting

confidence: 80%

Injection of Cerium Oxide Nanoparticles To Treat Spinal Cord Injury In Rats

Behroozi

Rahimi

Hamblin

et al. 2021

Preprint

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“…These peculiar chemical and physical features make CeO 2 -NPs a promising and exciting compound for biomedical applications. This is further favoured by the absence of toxicity in several tissues as demonstrated by multiple studies either in vitro and in vivo [ 151 ]. Nonetheless, some data indicate a certain degree of citotoxicity and therefore further study is needed to deepen the biocompatibility of CeO 2 -NPs [ 152 ].…”

Section: Nanoceria: a New Nanotechnology Approach To Combat Amd-inmentioning

confidence: 99%

The Impact of Oxidative Stress on Blood-Retinal Barrier Physiology in Age-Related Macular Degeneration

Tisi

Feligioni

Passacantando

et al. 2021

Cells

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The blood retinal barrier (BRB) is a fundamental eye component, whose function is to select the flow of molecules from the blood to the retina and vice-versa, and its integrity allows the maintenance of a finely regulated microenvironment. The outer BRB, composed by the choriocapillaris, the Bruch’s membrane, and the retinal pigment epithelium, undergoes structural and functional changes in age-related macular degeneration (AMD), the leading cause of blindness worldwide. BRB alterations lead to retinal dysfunction and neurodegeneration. Several risk factors have been associated with AMD onset in the past decades and oxidative stress is widely recognized as a key factor, even if the exact AMD pathophysiology has not been exactly elucidated yet. The present review describes the BRB physiology, the BRB changes occurring in AMD, the role of oxidative stress in AMD with a focus on the outer BRB structures. Moreover, we propose the use of cerium oxide nanoparticles as a new powerful anti-oxidant agent to combat AMD, based on the relevant existing data which demonstrated their beneficial effects in protecting the outer BRB in animal models of AMD.

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“…Inorganic nanoparticles suitable for nanomedicine include gold [110][111][112][113][114] and silver [115,116] nanoparticles, cerium dioxide [117,118], silica [119,120], as well as inorganic salts [121][122][123].…”

Section: Inorganic Particlesmentioning

confidence: 99%

Nanotechnology for Topical Drug Delivery to the Anterior Segment of the Eye

Vaneev

Tikhomirova

Чеснокова

et al. 2021

IJMS

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Topical drug delivery is one of the most challenging aspects of eye therapy. Eye drops are the most prevalent drug form, especially for widely distributed anterior segment eye diseases (cataracts, glaucoma, dry eye syndrome, inflammatory diseases, etc.), because they are convenient and easy to apply by patients. However, conventional drug formulations are usually characterized by short retention time in the tear film, insufficient contact with epithelium, fast elimination, and difficulties in overcoming ocular tissue barriers. Not more than 5% of the total drug dose administered in eye drops reaches the interior ocular tissues. To overcome the ocular drug delivery barriers and improve drug bioavailability, various conventional and novel drug delivery systems have been developed. Among these, nanosize carriers are the most attractive. The review is focused on the different drug carriers, such as synthetic and natural polymers, as well as inorganic carriers, with special attention to nanoparticles and nanomicelles. Studies in vitro and in vivo have demonstrated that new formulations could help to improve the bioavailability of the drugs, provide sustained drug release, enhance and prolong their therapeutic action. Promising results were obtained with drug-loaded nanoparticles included in in situ gel.

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<p>Antioxidant and toxicity studies of biosynthesized cerium oxide nanoparticles in rats</p>

Cited by 51 publications

References 57 publications

Injection of Cerium Oxide Nanoparticles To Treat Spinal Cord Injury In Rats

Injection of Cerium Oxide Nanoparticles To Treat Spinal Cord Injury In Rats

The Impact of Oxidative Stress on Blood-Retinal Barrier Physiology in Age-Related Macular Degeneration

Nanotechnology for Topical Drug Delivery to the Anterior Segment of the Eye

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