&lt;p&gt;Anxiety and Depression in Eosinophilic Esophagitis: A Scoping Review and Recommendations for Future Research&lt;/p&gt;

Taft, Tiffany; Guadagnoli, Livia; Edlynn, Emily

doi:10.2147/jaa.s193045

Cited by 44 publications

(41 citation statements)

References 52 publications

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“…Mental health has only very recently been investigated in adult patients with EoE. A 2019 scoping review 32 of anxiety and depression in adults with EoE found only 11 studies in adult patients, with 6 of these measuring anxiety via a measure of HRQoL (EoE-QOL-A) vs a psychiatric questionnaire, such as the Hospital Anxiety and Depression Scale (HADS). In the only cross-sectional study before 2019 specifically measuring anxiety via the HADS, 31.1% of 170 patients scored above the clinical cutoff for anxiety.…”

Section: Discussionmentioning

confidence: 99%

Esophageal Hypervigilance and Symptom-Specific Anxiety in Patients with Eosinophilic Esophagitis

et al. 2021

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BACKGROUND & AIMS: Patient symptom reporting often does not correlate with the pathophysiological markers of esophageal disease, including eosinophilic esophagitis (EoE). Esophageal hypervigilance and symptom-specific anxiety are emerging as important considerations in understanding symptom reporting. As such, we aimed to conduct the first study of these constructs in EoE. METHODS: A retrospective review of an EoE patient registry was conducted and included eosinophils per high power field (from esophagogastroduodenoscopy biopsy: proximal, distal), endoscopic reference score, distal distensibility plateau (functional luminal imaging probe), Brief Esophageal Dysphagia Questionnaire, Visual Dysphagia Question of EoE Activity Index, Northwestern Esophageal Quality of Life scale, and the Esophageal Hypervigilance and Anxiety Scale. Correlational and regression analyses evaluated relationships of hypervigilance and anxiety with Brief Esophageal Dysphagia Questionnaire, Visual Dysphagia Question of EoE Activity Index, and Northwestern Esophageal Quality of Life scale when controlling for histology and endoscopic severity. RESULTS: One hundred and three patients had complete data, 69.9% were male, and the mean (SD) age was 40.66 (13.85) years. Forty-one percent had elevated dysphagia and 46% had elevated hypervigilance and anxiety. Esophageal symptom-specific anxiety emerged as the most important predictor of Brief Esophageal Dysphagia Questionnaire severity (44.8% of the variance), Visual Dysphagia Question of EoE Activity Index severity (26%), and poor health-related quality of life (HRQoL) (55.3%). Hypervigilance was also important, but to a lesser extent. Pathophysiological variables did not significantly predict symptoms or HRQoL. Recent food impaction can predict symptom-specific anxiety and proton pump inhibitor use can reduce hypervigilance. CONCLUSIONS: Hypervigilance and symptom-specific anxiety are important for our understanding of self-reported patient outcomes in EoE. These processes outweigh endoscopic and histologic markers of EoE disease activity across dysphagia, difficulty eating, and HRQoL. Clinicians should assess hypervigilance and anxiety, especially in patients with refractory symptoms and poor HRQoL.

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Section: Discussionmentioning

confidence: 99%

Esophageal Hypervigilance and Symptom-Specific Anxiety in Patients with Eosinophilic Esophagitis

et al. 2021

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“…Jose et al found that parents of pediatric patients with EoE reported more school avoidance compared to patients without EoE [ 12 ]. Therapy, especially dietary elimination, has been shown to lead to increased worry about embarrassment in social situations [ 13 ]. This study showed that despite the burdens of disease, social functioning remained relatively well-preserved.…”

Section: Discussionmentioning

confidence: 99%

“…This study presents several questions about the quality of life, which should be further investigated. A number of studies have assessed the impact of EoE on specific aspects of physical and psychological functioning such as dysphagia, pain, anxiety, and depression [ 6 , 9 , 13 ]. However, it would be beneficial to investigate other aspects of school and social functioning such as perceptions of support from peers and teachers and adequacy of provisions for the patient at school.…”

Section: Discussionmentioning

confidence: 99%

Measurement of Quality-of-Life Outcomes in Pediatric and Young Adult Patients Treated for Eosinophilic Esophagitis

Chen¹,

Barry²,

Selvakumar³

et al. 2022

Cureus

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Eosinophilic esophagitis is a chronic, immune-mediated esophageal condition that may lead to impairment of quality of life in pediatric and young adult patients. We performed a prospective, cross-sectional study on 40 patients between the ages of 2-21 years with an established diagnosis of eosinophilic esophagitis. The study evaluated physical, emotional, social, and school functioning in patients undergoing treatment with proton pump inhibitors, dietary elimination, or swallowed corticosteroids. There were no statistically significant differences in total or domain-specific quality of life scores between proton pump inhibitors, dietary elimination, and swallowed corticosteroid therapy. Overall, total and domain-specific quality of life were well-preserved in patients with eosinophilic esophagitis, with the highest scores reported in social functioning. There were also no statistically significant associations between clinical, endoscopic, and histologic features and quality-of-life measures.

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“…Patients with EGIDs usually report impaired quality of life, due to both their disease and EGID-related therapies [ 32 , 33 , 34 ]. Thus, we have investigated the psychological impact of COVID-19 outbreak in our population.…”

Section: Discussionmentioning

confidence: 99%

Clinical and Psychological Impact of COVID-19 Infection in Adult Patients with Eosinophilic Gastrointestinal Disorders during the SARS-CoV-2 Outbreak

Savarino

Iovino

Santonicola

et al. 2020

JCM

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Eosinophilic gastrointestinal diseases (EGIDs) are chronic gastrointestinal conditions requiring corticosteroid and immunosuppressive therapy for disease control. Patients with EGIDs usually report impaired quality of life. We aimed to report the clinical and psychological impact of COVID-19 infection in EGID patients. In this prospective web-based study we invited all consecutive EGID patients attending the University Hospital of Salerno (Campania) and Padua (Veneto) to fill an ad hoc COVID-19 survey. Moreover, a telemedicine service for direct consultation was organized. Data regarding the occurrence and perception of COVID-19 infection as well as clinical information were recorded. The study population included 102 EGID patients (mean age 36.6 years, 34 females), of whom 89 had eosinophilic esophagitis, nine had gastroenteritis, and four had colitis. No patient was diagnosed with COVID-19 or had recurrence of his/her primary disease. All of them were adherent to therapy and preventive measures adoption. Most patients were worried because of COVID-19 and social preventing measures but did not consider themselves at major risk or susceptible to COVID-19 or other infections due to their chronic condition or therapy. Female gender and low education level were associated to a higher psychological perception of COVID-19 compared to lockdown status or other demographic and clinical factors (p < 0.05). Overall, COVID-19 had a limited clinical impact on patients with EGIDs. The degree of education and sex, but not the fact of living in a lockdown area, influenced the perception of SARS-CoV-2 infection.

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<p>Anxiety and Depression in Eosinophilic Esophagitis: A Scoping Review and Recommendations for Future Research</p>

Cited by 44 publications

References 52 publications

Esophageal Hypervigilance and Symptom-Specific Anxiety in Patients with Eosinophilic Esophagitis

Esophageal Hypervigilance and Symptom-Specific Anxiety in Patients with Eosinophilic Esophagitis

Measurement of Quality-of-Life Outcomes in Pediatric and Young Adult Patients Treated for Eosinophilic Esophagitis

Clinical and Psychological Impact of COVID-19 Infection in Adult Patients with Eosinophilic Gastrointestinal Disorders during the SARS-CoV-2 Outbreak

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