<p>Approach to residual dizziness after successfully treated benign paroxysmal positional vertigo: effect of a polyphenol compound supplementation</p>

Abstract

Purpose To assess if a polyphenol compound supplementation (Vertigoval ® ) could improve residual dizziness earlier after benign paroxysmal positional vertigo (BPPV) and relieve patients from this disabling symptomatology. Methods In this prospective, multicentric study, 127 patients were randomized in the treatment group (TG), who received a 60-day supplementation, while 131 patients were randomized in the control group (CG), who did not receive any medication. The dizziness handicap inventory (DHI) score, static posturography, and the visual analog scale (VAS) for both dizziness (D-VAS) and nausea/vomit (N/V-VAS) were used as measures of outcome at baseline and after 30 and 60 days. Patients were asked about efficacy and tolerance to the treatment. Side effects were examined. Results A statistically significant greater decrease was established in the TG for DHI, D-VAS, and N/V-VAS compared to the CG. On the other hand, static posturography did not show statistical differences between the two groups, though a better clinical improvement after 60-day supplementation was shown in the TG in comparison to the CG. We counted mild side effects in only 2 patients. Most patients reported an excellent or good efficacy and tolerance to the treatment. Conclusion Residual dizziness is a frequent condition of unknown origin that manifests as persistent disabling imbalance after successful repositioning maneuvers for BPPV. The decreasing postural control can affect the quality of life, contributing to falling and psychological problems. The supplementation with the polyphenol compound used in our study is safe, manageable, and appeared to be able to reduce subjective symptoms and improve instability earlier, decreasing the risk of potential complications.

Nutraceuticals for Peripheral Vestibular Pathology: Properties, Usefulness, Future Perspectives and Medico-Legal Aspects

“…Non specific and generally used in vertigo/dizziness. A formulation containing lemon balm was effective in BPPV [61].…”

“…Improvements in mood and cognitive performance, antioxidant, anti-inflammatory, anti-nociceptive, hypoglycaemic, hyperlipidaemic, cardiologic, cytotoxic, antimicrobic, antispasmodic, antiepileptic effects are described. May be used in the management of various neurological pathologies or symptoms [60][61][62][63].…”

“…Combination of apple and grape polyphenols with vasodilator and antioxidant effect [61]. Non-specific.…”

“…NA. Vitamin B6 protects circulation and seems to facilitate vestibular system, acting on vertigo [61,84,85]. Vitamin B2, B3, and B6 aid nervous system.…”

Low Antioxidant Status of Serum Uric Acid, Bilirubin, Albumin, and Creatinine in Patients With Benign Paroxysmal Positional Vertigo

“…However, at present, there are limited methods and techniques available to evaluate the condition of semicircular canals and vestibules, and the physiopathological explanations of BPPV are mainly speculative. Although most recover after positional maneuvers, up to 2/3 of patients may experience chronic, obstructive instability, dizziness, and discomfort, also known as residual dizziness (3). Meanwhile, the relapse rate of BPPV in the elderly is reportedly 23.5-50% (4).…”