<p>Associated factors for depressive disorder in patients with end-stage renal disease treated with continuous ambulatory peritoneal dialysis</p>

Abstract

Background The aim of this study was to primarily determine factors associated with the depressive disorders in continuous ambulatory peritoneal dialysis (CAPD). Methods CAPD patients were recruited from the chronic kidney disease and CAPD Clinic of University Hospital. The stable CAPD patients for at least 3 months were included in the study. Sociodemographic data, renal conditions, and depressive disorder were evaluated. In addition to determining prevalence rate of depressive disorders, identification of factors associated with depressive disorders in CAPD patients were analyzed by using the multivariable logistic regression analysis with backward elimination procedure. Results The eligible participants were 108 patients. The study found that 11% of CAPD patients were diagnosed with depressive disorders including, minor depressive, dysthymic, and major depressive disorders. Additionally, the depressive disorders were associated with the duration between the diagnosis date of the end-stage renal disease (ESRD) and the initial treatment date ( P =0.043). Accordingly, the ESRD patients diagnosed in <12 months had 3.57-fold higher risk of depressive disorders than the patients diagnosed after a long time. Conclusion The rate of prevalence for depressive disorder is high in the CAPD patients. Additionally, the results of this study have shown the relationship between depressive disorder and time for diagnosis of ESRD. Specifically, the risk of depressive disorder increases when patients have a shorter duration between the dates of ESRD diagnosis and initial treatment. In addition to closed monitoring for those patients, the psychiatrists should be consulted for evaluation and treatment of depressive disorders for the suspected high risk patients.

Assessment of stress level and prevalence of depression among haemodialyzed patients

“…Limitations of the study our study had certain limitations -it did not include potentially relevant variables (such as co-existing chronic diseases, sleep disorders, lack of data on inflammatory markers, duration of illness), which could significantly influence the level of stress and prevalence of depression [7,26,27]. the listed criteria will be taken into account when extending the tests carried out so far.…”

“…an underlying assumption behind the aetiology of depression, inter alia, is that individuals genetically predisposed to a specific psychological disorder may develop depression due to negative or stressful life experiences. other factors which contribute to the development of depressive disorders are incorrect cognitive constructs arising from social learning and certain personality traits [5][6][7].…”

“…additionally, biological agents which are accountable for chronic kidney disease, such as cytokines, deregulation of stress (hypothalamic-pituitary-adrenal, hPa) axis, imbalance of glucose and insulin homeostasis, as well as oxidative stress and raised inflammatory markers among haemodialyzed patients, may cause depression [7]. Difficult, long-term therapy affects the quality of life and requires patients to alter their way of living, impairs daily life activity and interferes with self-esteem and the sense of self-identity, which causes a loss of adopted social and professional roles.…”

Prevalence and predisposing factors of depressive symptoms in continuous ambulatory peritoneal dialysis patients: a cross-sectional single center study

“…The occurrence of depressive disorder in end-stage renal disease patients was associated with the assessment tool for screening depression and many sociodemographic and clinical characteristics, such as sex, age, occupation, malnutrition, comorbidity, and time since diagnosis [ 4 , 8 – 11 ].…”

The Effect of Positive Thinking Training on Different Dimensions of Quality of Life of Hemodialysis Patients: A Randomized Controlled Clinical Trial

“…When the kidneys are unable to perform their normal functions, alternative therapies should be applied, the most common of which is hemodialysis (1,2). While the hemodialysis has increased the life expectancy of patients with kidney failure, it has caused significant psychological, social, and physical problems as well as negative effects on the Quality of Life (QoL) of patients who use hemodialysis (3,4).…”