<p>Association between glycemic status and thyroid dysfunction in patients with type 2 diabetes mellitus</p>

Abstract

Background Thyroid dysfunction has been widely reported to be more common in patients with type 2 diabetes mellitus (T2DM) in various parts of the world; however, there is paucity of data on this in our environment. Objective The aim of this study was to determine the possible relationship between glycemic status and thyroid dysfunction. Methodology A total of 354 T2DM patients and 118 non-diabetic persons (controls) were recruited for the study. A pretested questionnaire was filled for each subject after due explanations. Their blood samples were tested for HbA1c, fT3, fT4, and TSH. Information retrieved from patient's medical records included age at diagnosis of diabetes (DM) and duration of DM. Testing statistics done included Student's t -test, chi square test, and regression analysis. P -value of less than 0.05 was taken to be statistically significant. Results The results show that 43.5% and 37.3% of T2DM and control subjects, respectively, were males. Mean HbA1c was significantly higher in T2DM patients than in the controls (7.8±2.0% vs 5.8±1.2%, p =0.001), while mean fT3 was significantly lower in T2DM patients than in the controls (2.3±1.5 pg/mL vs 2.7±2.2 pg/mL, p =0.03). Mean HbA1c was significantly higher in T2DM patients with thyroid dysfunction compared to their euthyroid counterparts (8.1±1.9% vs 5.1±1.2%, p =0.001). HbA1c had a positive linear relationship with the presence of thyroid dysfunction (regression coefficient=1.89, p =0.001). Conclusion There was a positive linear relationship between HbA1c and the presence of thyroid dysfunction in the T2DM patients in this study. There was an inverse relationship between HbA1c and serum fT3.

Prospective role of thyroid disorders in monitoring COVID-19 pandemic

“…Diabetic patients with hypothyroidism are susceptible to periodic hypoglycemic episodes. In addition, severe hyperthyroidism may lead to hyperglycemia [ 86 , 87 , 88 ]. Reports suggest that diabetic individuals are more likely to develop thyroid nodules [ 89 ].…”

Determinants of deranged thyroid function parameters in children admitted for management of diabetic ketoacidosis/diabetic ketosis

“…In addition, ICU patients with ESS tend to experience more severe symptoms compared to those with normal thyroid function [8]. Thyroid dysfunction occurs more often in diabetic patients relative to the general population while poor glycemic control coincides with a lower level of free T3 (FT3) in serum [9]. ESS in children with T1DM results in poor metabolic control and ketoacidosis [10,11].…”

<p>Prevalence and Predictors of Thyroid Dysfunction Among Type 2 Diabetic Patients: A Case–Control Study</p>

“…56 Several studies showed an inverse relationship between serum FT3 and HbA1c, and a positive relationship between TSH and HbA1c in the T2DM patients that could be attributed to the effect of prolonged hyperglycemia on the peripheral deiodination of T4 to T3. 33,34,57 These studies indicate that blood glucose, particularly HbA1c, can affect thyroid hormones. Thus, strict glycemic control can improve thyroid function and even correct thyroid hormone abnormalities without the need for thyroid dysfunction treatment.…”