<p>Association between <em>ADORA2A</em> gene polymorphisms and schizophrenia in the North Chinese Han population</p>

Abstract

BackgroundA large number of studies have shown a close relationship between ADORA2A and the pathological mechanism of schizophrenia. However, to our knowledge, there has been no studies examining the association between the ADORA2A gene and schizophrenia in Chinese Han population.PurposeThe objective of this study was to examine the relationship between adenosine A2A receptor (ADORA2A) single nucleotide polymorphisms and schizophrenia in the North Chinese Han population.Patients and methodsWe detected ADORA2A single nucleotide polymorphisms (SNPs) using polymerase chain reaction-restriction fragment length polymorphism analyses and summarized our results using SPSS statistical software and Haploview in schizophrenia case group (n=398) and healthy control group (n=535).ResultsThe frequency of the CC homozygote genotype of SNP rs2298383T/C were significantly higher in the case than the control group (p=0.005, OR=1.712, 95% CI=1.172–2.502). After linkage disequilibrium analysis, SNPs rs5996696A/C and rs2298383T/C displayed strong linkage disequilibrium. We found that the frequencies of haplotypes TA (χ2=6.268, p=0.0123) and CA (χ2=7.012, p=0.0081) were significantly higher in the case group than in the control group.ConclusionIn conclusion, SNPs in the ADORA2A gene may be associated with schizophrenia in the northern Chinese Han population.

Allosteric Interactions between Adenosine A2A and Dopamine D2 Receptors in Heteromeric Complexes: Biochemical and Pharmacological Characteristics, and Opportunities for PET Imaging

“…In accordance with such hypotheses, A 2A R were found to be upregulated in the striatum [ 183 , 184 ] and hippocampus [ 185 ] of chronic schizophrenics (although this upregulation could also be a consequence of the antipsychotic treatment that the patients received). A Chinese study reported significant associations between single nucleotide polymorphisms of the A 2A R gene and schizophrenia in the northern Chinese Han population [ 186 ].…”

Glial Purinergic Signaling-Mediated Oxidative Stress (GPOS) in Neuropsychiatric Disorders

“…However, the underlying mechanism mainly focused on purinergic receptor polymorphisms and interaction with dopamine receptors and NMDA receptors. The link between adenosine A2A receptor gene polymorphism located on chromosome 22q and susceptibility to SZ was reported [93,94]. By measuring the polymorphisms in ADORA1, ADORA2A, and ADORA3, a study found a correlation between ADORA1 rs3766566 and positive psychopathological symptoms, ADORA2A rs2298383 and general psychopathological symptoms, and ADORA2A rs5751876 and akathisia [95].…”

Insights into the Promising Prospect of G Protein and GPCR-Mediated Signaling in Neuropathophysiology and Its Therapeutic Regulation

“…A2a receptor provides a candidate schizophrenia susceptibility gene [163], which, again, ties the adenosine A2a receptor to various mental disorders that include schizophrenia, as well as depression and anxiety. As indicated by a variety of studies, the adenosine A2a receptor "fine tunes" glutamatergic and dopaminergic network balance [164].…”

“…This appears to be particularly likely in relation to A 2A receptor-D 2 receptor heteromers and potentially accounts for their known allosteric mechanisms and multiple unique pharmacological and biochemical properties. On chromosome 22q12–13, a single nucleotide polymorphism (SNP) on the A2a receptor provides a candidate schizophrenia susceptibility gene [ 163 ], which, again, ties the adenosine A2a receptor to various mental disorders that include schizophrenia, as well as depression and anxiety. As indicated by a variety of studies, the adenosine A2a receptor “fine tunes” glutamatergic and dopaminergic network balance [ 164 ].…”