&lt;p&gt;Association Between Serum Calcium and Phosphorus Levels and Insulin-Like Growth Factor-1 in Chinese Children and Adolescents with Short Stature&lt;/p&gt;

Sun, Minghui; Yan, Wenhua; Zhao, Qianqian; Ji, Baolan; Ban, Bo; Zhang, Mei

doi:10.2147/ijgm.s276261

Cited by 8 publications

(11 citation statements)

References 35 publications

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“…Multiple regression analysis showed a significant association between serum P with serum Ca, Zn, and IGF-1 (R 2 = 0.337, p = 0.000). In a study of 747 children of short stature, there was a positive correlation between serum P and IGF-1 SDS when the serum P concentration was greater than 3.9 mg/dL [61]. In the obesity group, serum P was associated with the Cu/Zn and Zn/Cu ratios, and IGF-1 with serum P was associated with serum Cu.…”

Section: Serum Cu Levelsmentioning

confidence: 97%

Copper and Copper/Zn Ratio in a Series of Children with Chronic Diseases: A Cross-Sectional Study

et al. 2021

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Copper is an essential micronutrient for humans. A cross-sectional and comparative study was done to assess serum Cu levels and serum copper/zinc (Cu/Zn) ratio and its association with nutritional indicators in a series of children and adolescents with chronic diseases. Anthropometric, biochemical, dietary, body composition, and bone densitometry assessments were carried out. Serum Cu and Zn were measured by atomic absorption spectrophotometry. Seventy-eight patients (55% women) participated. The mean serum Cu in the entire series and by nutritional status through body mass index (BMI) was normal. Serum Cu decreased significantly with age and was meaningfully higher in children than in adolescents. The risk of finding altered Cu levels in children and men was higher than in adolescents and women, respectively. Twenty-two per cent of patients had abnormal serum copper levels, 13 had hypercupremia, and four had hypocupremia. The Cu/Zn ratio was greater than 1.00 for 87% of the patients, which is an indicator of an inflammatory state. All patients with hypozincemia and hypocupremia had deficient Zn intake, but only 65% of the patients with hypercupremia had dietary Zn deficiency. Consequently, the Cu/Zn ratio could indicate an inflammatory state and a high risk of zinc deficiency in this specific child population.

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Section: Serum Cu Levelsmentioning

confidence: 97%

Copper and Copper/Zn Ratio in a Series of Children with Chronic Diseases: A Cross-Sectional Study

et al. 2021

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“…Studies by Sun et al [22] demonstrated that in Chinese children and adolescents with short stature, circulating calcium and phosphorus concentrations may be associated with the regulation of IGF-1 levels, and this relationship merits further investigation. Khadilkar et al [23] proved that calcium and vitamin D supplementation has a positive influence on an increase in bone minerals in children with SHP who were treated with GH.…”

Section: Discussionmentioning

confidence: 97%

“…The mean values remained within normal limits before treatment and did not differ, namely, statistically significant after the introduction of hormonal therapy: calcium 9.1+/-0.2 mg/dl vs. 10.11+/-0.57mg/dl, phosphorus 4.38+/-0.45mg/dl vs. 4.53+/-0.55mg/dl). Minghui et al [2] described a positive correlation between IGF-1 and serum calcium, and a non-linear relationship between IGF-1and serum phosphorus by adjusting for potential confounding factors in children and adolescents with short stature. This finding suggests that serum calcium and phosphorus levels in children and adolescents with short stature may affect IGF-1 concentrations.…”

Section: Discussionmentioning

confidence: 99%

“…Phosphorus is found in food; thus, its insufficiency in the body is rare. Long-lasting lack can lead to rickets, decalcification of the bones and growth disorders [2].…”

Section: Short Stature (Ss) -Disorders Of Height and Developmentmentioning

confidence: 99%

“…Calcium is needed for muscle contraction, hormone release, blood clotting concatenation and neuronal excitation. Phosphorus is involved in the body's energy metabolism, nucleic acid synthesis, and cell signalling conduction and cell membrane stabilization [2]. The regulation of calcium and phosphates concentration in the serum depends on the combined activity of the parathyroid hormone (PTH), vitamin D and calcitonin.…”

Section: Introductionmentioning

confidence: 99%

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Vitamin D, calcium and phosphorus status in children with short stature – effect of growth hormone therapy

Klatka¹,

Partyka²,

Polak³

et al. 2021

Ann Agric Environ Med.

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Objective. The aim of the study was to assess the level of calcium, phosphorus and vitamin D in the blood of patients treated for short stature (SS). Materials and method. The study encompassed 110 children treated for somatotropin hypopituitarism (SHP) in the Department of Paediatric Endocrinology and Diabetology at the Medical University of Lublin. The levels of calcium, phosphorus and vitamin D were marked for both groups in the peripheral blood collected on a routine basis for diagnostic examinations. The parameters were compared within the group of children with SHP, both the patients who were about to start the therapy and those in the course of the therapy as well as between the research group (110 children) and the control group. Results. The results obtained were compared with the results in the control group that comprised 41 children with a general good health status, although with nasal septum deviation treated in the Department of Paediatric Otolaryngology at the Medical University of Lublin. Conclusions. On the basis of the research performed, the following conclusions were drawn: 1) children with SHP were characterised with calcium-phosphorus imbalance. The level of calcium, phosphorus and vitamin D was diminished. The values did not change due to a several-year hormone growth treatment (HGT). 2) the level of calcium and phosphorus was appropriate in the control group children, but the vitamin D level was considerably lowered. This shows the necessity for vitamin D control and supplementation, not only in children with SS.

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Effect of Calcium and Vitamin D Supplementation (Dairy vs. Pharmacological) on Bone Health of Underprivileged Indian Children and Youth with Type-1 Diabetes: A Randomized Controlled Trial

Khadilkar,

Oza,

Antani

et al. 2024

Journal of Clinical Densitometry

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<p>Association Between Serum Calcium and Phosphorus Levels and Insulin-Like Growth Factor-1 in Chinese Children and Adolescents with Short Stature</p>

Cited by 8 publications

References 35 publications

Copper and Copper/Zn Ratio in a Series of Children with Chronic Diseases: A Cross-Sectional Study

Copper and Copper/Zn Ratio in a Series of Children with Chronic Diseases: A Cross-Sectional Study

Vitamin D, calcium and phosphorus status in children with short stature – effect of growth hormone therapy

Effect of Calcium and Vitamin D Supplementation (Dairy vs. Pharmacological) on Bone Health of Underprivileged Indian Children and Youth with Type-1 Diabetes: A Randomized Controlled Trial

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