&lt;p&gt;Associations Between Thyroid Hormones and Glycated Albumin in Euthyroid and Subclinical Hypothyroid Individuals: Results of an Observational Study&lt;/p&gt;

Nie, Xiaomin; Shen, Yun; Ma, Xiaojing; Xu, Yiting; Wang, Yufei; Zhou, Jian; Bao, Yuqian

doi:10.2147/dmso.s236698

Cited by 9 publications

(9 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, contradictory findings were reported in others (17,35,36). Similar to our findings in pregnant women, several crosssectional studies among Chinese population reported that a decreased sensitivity/increased resistance to thyroid hormones were associated with reduced risk of pre-diabetes (17), lowered levels of HbA1c (35), or body mass index (BMI) (36). A crosssectional study (17) among Chinese adults reported that per SD increase in TSHI, TT4RI, and parametric TFQI and decrease in FT3/FT4 were associated with decreased risk of prediabetes by 9%-11%.…”

Section: Results Explanation and Potential Mechanisms Of Thyroid Resi...mentioning

confidence: 84%

“…Elevated indices of thyroid resistance has been observed to be associated with multiple unfavorable metabolic factors or disorders in general population including adipocyte fatty-acidbinding protein (34), obesity (15), type 2 diabetes, metabolic syndromes, or even diabetes-related mortality (14). However, contradictory findings were reported in others (17,35,36). Similar to our findings in pregnant women, several crosssectional studies among Chinese population reported that a decreased sensitivity/increased resistance to thyroid hormones were associated with reduced risk of pre-diabetes (17), lowered levels of HbA1c (35), or body mass index (BMI) (36).…”

Section: Results Explanation and Potential Mechanisms Of Thyroid Resi...mentioning

confidence: 99%

See 1 more Smart Citation

Increased Central and Peripheral Thyroid Resistance Indices During the First Half of Gestation Were Associated With Lowered Risk of Gestational Diabetes—Analyses Based on Huizhou Birth Cohort in South China

Liu

et al. 2022

Front. Endocrinol.

View full text Add to dashboard Cite

ObjectivesThe study aimed to explore the relationship of thyroid function and resistance indices with subsequent risk of gestational diabetes (GDM).DesignThis was a longitudinal study embedded in the Huizhou Birth Cohort.MethodsA total of 2,927 women of singleton pregnancy were recruited from January to October of 2019. Thyroid central resistance indices were evaluated by Thyroid Feedback Quartile-Based index (TFQI), Thyrotrophy T4 Resistance Index (TT4RI), and TSH Index (TSHI) based on plasma-free thyroxine (FT4) and thyroid-stimulating hormone (TSH) levels during the first half of pregnancy. Thyroid peripheral sensitivity was assessed by free triiodothyronine (FT3) to FT4 ratio (FT3/FT4), a proxy of deiodinase activity. GDM was diagnosed between 24 and 28 weeks of gestation by a standardized 75 g oral glucose tolerance test. Multivariable linear and logistic regression was applied to examine the associations of thyroid markers with GDM risk.ResultsFT3 and FT3/FT4 were positively associated with both fasting and post-load glucose levels, while TSH, TSHI, TT4RI, and TFQI were negatively associated with 1 and 2 h post-load glucose levels. Compared with the lowest quartile, GDM risk in the highest quartile increased by 44% [odds ratio (OR) = 1.44; 95%CI, 1.08–1.92; ptrend = 0.027] for FT3 and 81% (OR = 1.81; 95%CI, 1.33–2.46; ptrend < 0.001) for FT3/FT4, while it lowered by 37% (OR = 0.63; 95%CI, 0.47–0.86; ptrend = 0.002] for TSHI, 28% for TT4RI (OR = 0.72; 95%CI, 0.54–0.97; ptrend = 0.06), and 37% for TFQI (OR = 0.63; 95%CI, 0.46–0.85; ptrend < 0.001).ConclusionsThis longitudinal study indicated that higher FT3 and FT3/FT4 and lower central thyroid resistance indices were associated with increased risk of GDM.

show abstract

Section: Results Explanation and Potential Mechanisms Of Thyroid Resi...mentioning

confidence: 84%

Section: Results Explanation and Potential Mechanisms Of Thyroid Resi...mentioning

confidence: 99%

Increased Central and Peripheral Thyroid Resistance Indices During the First Half of Gestation Were Associated With Lowered Risk of Gestational Diabetes—Analyses Based on Huizhou Birth Cohort in South China

Liu

et al. 2022

Front. Endocrinol.

View full text Add to dashboard Cite

show abstract

“…Contrary to most previous studies, our result showed decreased sensitivity to thyroid hormones has a protective effect on prediabetes, which was consistent in subgroup analyses among different age, gender, and BMI categories. A cross-sectional study in China also found a negative association between HbA 1c and TSHI, though it did not reach statistical significance ( 24 ). The contradictory results from the aforementioned studies could be attributed to differences in age, gender, ethnicity, and iodine status of study population.…”

Section: Discussionmentioning

confidence: 99%

Sensitivity to Thyroid Hormones and Risk of Prediabetes: A Cross-Sectional Study

Liu

Wang

et al. 2021

Front. Endocrinol.

View full text Add to dashboard Cite

ContextThyroid hormone influences glucose homeostasis through central and peripheral regulations. To date, the link between sensitivity to thyroid hormones and prediabetes remains unknown. We aimed to investigate the association between thyroid hormones sensitivity and risk of prediabetes in both general and euthyroid populations.MethodsParticipants with serum free triiodothyronine (FT3), free thyroxine (FT4), and thyrotropin (TSH) measurements from the health checkup programs of the First Hospital of China Medical University were collected. We measured the parameters representing central and peripheral sensitivities to thyroid hormones (central sensitivity, assessed by calculating Thyroid Feedback Quantile-based Index (TFQI), TSH Index (TSHI), and Thyrotroph Thyroxine Resistance Index (TT4RI); peripheral sensitivity, evaluated by FT3/FT4 ratio). Associations between thyroid hormones sensitivities and risk of prediabetes were assessed with logistic regression.ResultsA total of 4378 participants (mean age ± SD, 49 ± 11 years) were included, with 1457 (33%) subjects had prediabetes. The risk of prediabetes was negatively associated with levels of TSHI (odds ratio [OR] 0.91; 95% confidence interval [CI], 0.85–0.97), TT4RI (OR 0.91; 95% CI, 0.84–0.99) and Parametric TFQI (PTFQI) (OR 0.89; 95% CI, 0.83–0.95) among all subjects. The association remained significant in euthyroid subjects and euthyroid subjects with negative thyroid autoimmunity. Higher FT3/FT4 ratio was associated with a mild increased risk of prediabetes (95% CI 1.09; 1.02–1.16). Compared with subjects in the lowest quartile of PTFQI, those in the highest quartile had lower risk of prediabetes (0.70; 95% CI, 0.58–0.84).ConclusionsDecreased central sensitivity to thyroid hormones is associated with lower risk of prediabetes. This demonstrates the complex interaction between thyroid system and glucose metabolism. Future studies are warranted to confirm our findings and underlying mechanisms.

show abstract

“…Thyroid hormones can promote the decomposition of albumin and affect the level of serum GA. Hyperthyroidism may lower the values of GA, while hypothyroidism may increase the values. Even in people with normal thyroid function, GA is negatively correlated with serum free triiodothyronine and free thyroxine 43 …”

Section: Gamentioning

confidence: 96%

Clinical application guidelines for blood glucose monitoring in China (2022 edition)

Bao

Zhu

2022

Diabetes Metabolism Res

Self Cite

View full text Add to dashboard Cite

Glucose monitoring is an important component of diabetes management. The Chinese Diabetes Society (CDS) has been producing evidence-based guidelines on the optimal use of glucose monitoring since 2011. In recent years, new technologies in glucose monitoring and more clinical evidence, especially those derived from Chinese populations, have emerged. In this context, the CDS organised experts to revise the Clinical application guidelines for blood glucose monitoring in China in 2021. In this guideline, we focus on four methods of glucose monitoring that are commonly used in clinical practice, including capillary glucose monitoring, glycated haemoglobin A1c, glycated albumin, and continuous glucose monitoring. We describe the definitions and technical characteristics of these methods, the factor that may interfere with the measurement, the advantages and caveats in clinical practice, the interpretation of glucose metrics, and the relevant supporting evidence. The recommendations for the use of these methods are also provided. The various methods of glucose monitoring have their strengths and limitations and cannot be replaced by one another. We hope that these guidelines could aid in the optimal application of common methods of glucose monitoring in clinical practice for better diabetes care. K E Y W O R D S diabetes, glucose monitoring, guideline 1 | INTRODUCTION Glucose monitoring, as an important part of diabetes management, serves to evaluate the glucose status and the effectiveness of glucose lowering therapies. Common methods of glucose monitoring that are used in clinical practice include capillary glucose monitoring (which includes self-monitoring of blood glucose [SMBG] and the point-ofcare testing [POCT] in hospital), glycated haemoglobin A1c (HbA1c), glycated albumin (GA), and continuous glucose monitoring (CGM). In 2011, the Chinese Diabetes Society (CDS) issued the Clinical application guideline for blood glucose monitoring in China ( 2011Edition) (hereinafter referred to as the guideline), and further revision was made in 2015. In recent years, glucose monitoring technology is evolving in a more convenient, accurate, and minimally invasive or even noninvasive direction. In order to further standardise the use of various tools based on the recent advancements in technologies and evidence, the guideline is revised and updated again.The guideline lists the recommendations at the beginning of each chapter and marks the level of evidence (Table 1). Evidence level A is the evidence based on multiple randomised controlled trials or metaanalysis; evidence level B is the evidence based on a single randomised controlled trial or multiple non-randomised controlled trials;This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

show abstract

<p>Associations Between Thyroid Hormones and Glycated Albumin in Euthyroid and Subclinical Hypothyroid Individuals: Results of an Observational Study</p>

Cited by 9 publications

References 32 publications

Increased Central and Peripheral Thyroid Resistance Indices During the First Half of Gestation Were Associated With Lowered Risk of Gestational Diabetes—Analyses Based on Huizhou Birth Cohort in South China

Increased Central and Peripheral Thyroid Resistance Indices During the First Half of Gestation Were Associated With Lowered Risk of Gestational Diabetes—Analyses Based on Huizhou Birth Cohort in South China

Sensitivity to Thyroid Hormones and Risk of Prediabetes: A Cross-Sectional Study

Clinical application guidelines for blood glucose monitoring in China (2022 edition)

Contact Info

Product

Resources

About