<p>Baseline Predictive Factors of Visual Outcome and Persistence of Subretinal Fluid Based on Morphologic Changes in Spectral Domain Optical Coherence Tomography in Patients with Idiopathic Central Serous Chorioretinopathy</p>

Abstract

BackgroundTo determine the influence of spectral domain optical coherence tomography (OCT) changes on visual outcome and persistence of subretinal fluid (SRF) in patients with idiopathic central serous chorioretinopathy (CSCR).Materials and methodsIn a retrospective study done in 48 eyes of 45 patients diagnosed as CSCR, all eyes were subjected to fundus photography, spectral domain OCT, and fluorescein angiography (FA) in selected cases.ResultsRetinal pigment epithelium detachment was present in 22.91% of the cases at presentation. The logMar best corrected visual acuity improved from 0.46±0.29 at presentation to 0.18±0.22 at 3 months (P-value<0.01). The mean foveal thickness was 486.81±146.06 µm at presentation and 259±94.5 µm at 3 months (P-value<0.01) (paired T-test). OCT factors that were associated with poor visual outcome (BCVA>0.3 logMar) were disruption in the inner segment (IS)/outer segment (OS) junction or external limiting membrane (ELM) line and hyper-reflective dots in the intra/subretinal layer (P-value<0.05) (Fischer’s Exact test). Out of the total 48 eyes, 26 had persistent SRF at 3 months. The presence of discontinuation in IS/OS junction and hyper-reflective dots in the intra/subretinal layer were the only two OCT factors that were associated with the persistence of SRF (P-value<0.01) (Pearson’s Chi-square test).ConclusionVisual outcome and persistence of subretinal fluid at 3 months can be predicted on the basis of early morphologic changes in OCT. This will aid in counseling patients regarding its course and may guide us in its management.

Effects of Ketoconazole On Clinical Recovery In Central Serous Chorioretinopathy

“…These cut-off values are close to the 75 th percentiles of our study's predictive values: choroidal thickness of >450 µm and age of >45 years. In contrast to some reports, we did not observe any association between either baseline BCVA or CST and the disease episode length [24,25].…”

Factors influencing the episode duration and the anatomical and functional outcome in cases of acute central serous chorioretinopathy

“… 16 30 31 The overall incidence of HRDs in our study was 35.48%. This is relatively low compared with the incidence rate of 66%, 65%, 57.4% and 50% in the studies by Yalcinbayir et al , 16 Maruko et al , 29 Lai et al 18 and Suwal et al 32 , respectively. Lee et al 17 stated that increased number of HRDs was associated with recurrences.…”

“…However, they did not observe any correlation between number of HRDs and the final visual outcome. In their study, Suwal et al 32 found that eyes with HRDs had persistence of SRF at the end of 3 months and were associated with poor visual outcome.…”

“…The overall incidence of RPE bumps in our study was 30.10%. The incidence of RPE bumps has been reported to be 46.4%, 8.1%, 45.2%, and 62.5% in studies by Yalcinbayir et al, 16 Lee et al, 17 Daruich et al, 33 and Suwal et al 32 We observed that the presence of RPE bumps in the baseline OCT was associated with significantly longer time for SRF resolution, and thinner final CMT, but it did not have any significant effect on the final visual outcome. No such relations were observed in other studies.…”

Retinal Diseases that Can Masquerade as Neurological Causes of Vision Loss

“…Early morphologic changes on OCT can predict visual outcome and persistence of fluid. [20] If fluid persists, laser photocoagulation or photodynamic therapy may be considered. [21,22]…”