&lt;p&gt;Biochemical but not compositional recovery of skin mucosal microbiome communities after disruption&lt;/p&gt;

Brumlow, Chelcy E; Luna, Ruth Ann; Hollister, Emily B.; Gómez, Jesús Gómez; Burcham, Lindsey A; Cowdrey, Madison; Primm, Todd P.

doi:10.2147/idr.s185992

Cited by 7 publications

(6 citation statements)

References 32 publications

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“…However, unlike the present results, where signi cant changes to microbial function were predicted, the results of Brumlow et al [47] indicated that the biochemical functions of microbiota were mostly reestablished after the 8 day recovery. Flumequine is a highly persistent antibiotic and it can take several weeks to be fully depleted from the blood and tissues of sh [48,49].…”

Section: Discussioncontrasting

confidence: 99%

Monitoring disease and antibiotic treatment in the skin microbiota of farmed seabass fingerlings

Rosado¹,

Pérez‐Losada²,

Severino

et al. 2021

Preprint

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The microbiota of fish skin is the primary barrier against disease; however, it is highly dynamic being modulated by several factors. In fish aquaculture, disease outbreaks occur mainly during early-life stages with high associated losses. Antibiotic treatments sometimes remain as the best option to control bacterial diseases, despite many reported negative impacts of its use on fish and associated microbiota. Notwithstanding, studies monitoring the effects of disease and antibiotic treatment on the microbiota of fingerlings are scarce. We used a 16S rRNA metataxonomic approach to assess the impact of a mixed infection with Photobacterium damselae ssp. piscicida and Vibrio harveyi and subsequent antibiotic treatment with flumequine, on the skin microbiota of farmed seabass Dicentrarchus labrax fingerlings. Both disease and antibiotic treatment led to a significant increase in bacterial diversity and core microbial communities and impacted microbial structure. Dysbiosis was confirmed by changes in the abundance of potential pathogenic and opportunistic bacterial taxa. Skin bacterial metabolic function was also significantly affected by flumequine administration, suggesting a detriment to fish skin health. Our results add to an increasing body of literature, showing how fish microbiome response to disease and antibiotics is not easily predicted.

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Section: Discussioncontrasting

confidence: 99%

Monitoring disease and antibiotic treatment in the skin microbiota of farmed seabass fingerlings

Rosado¹,

Pérez‐Losada²,

Severino

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…Almost half of the enriched metabolic pathways during the recovery state were related to the same categories of pathways enriched during the treatment state (carbohydrate and secondary metabolite degradation), with signi cant differences from the healthy state. To the best of our knowledge, only the study by Brumlow et al [47] has effectively measured the effects of 3-day antibiotic treatments (Tetracycline and Rifampicin) in the biochemical pro le of the skin of Gambusia a nis. In this study the authors also report changes in community composition relative to pre-treatment, after 8 day recovery.…”

Section: Discussionmentioning

confidence: 99%

Monitoring Infection and Antibiotic Treatment in the Skin Microbiota of Farmed European Seabass (Dicentrarchus Labrax) Fingerlings

Rosado

Pérez‐Losada

Severino³

et al. 2021

Microb Ecol

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The microbiota of sh skin is the primary barrier against disease; however, it is highly dynamic being modulated by several factors. In sh aquaculture, disease outbreaks occur mainly during early-life stages with high associated losses. Antibiotic treatments sometimes remain as the best option to control bacterial diseases, despite many reported negative impacts of its use on sh and associated microbiota. Notwithstanding, studies monitoring the effects of disease and antibiotic treatment on the microbiota of ngerlings are scarce. We used a 16S rRNA metataxonomic approach to assess the impact of a mixed infection with Photobacterium damselae ssp. piscicida and Vibrio harveyi and subsequent antibiotic treatment with umequine, on the skin microbiota of farmed seabass Dicentrarchus labrax ngerlings. Both disease and antibiotic treatment led to a signi cant increase in bacterial diversity and core microbial communities and impacted microbial structure. Dysbiosis was con rmed by changes in the abundance of potential pathogenic and opportunistic bacterial taxa. Skin bacterial metabolic function was also signi cantly affected by umequine administration, suggesting a detriment to sh skin health. Our results add to an increasing body of literature, showing how sh microbiome response to disease and antibiotics is not easily predicted.

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“…This community also interferes with infections [7][8][9], via competition or antagonistic interactions [10,11]. Dysbiosis of the skin microbial community can drive it out of homoeostasis and promote infection [12], although not every perturbation in the microbiome must lead to the loss of function [13].…”

Section: Introductionmentioning

confidence: 99%

Dissecting the factors shaping fish skin microbiomes in a heterogeneous inland water system

Krotman¹,

Yergaliyev

Shani

et al. 2020

Microbiome

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Background: Fish skin microbiomes are rarely studied in inland water systems, in spite of their importance for fish health and ecology. This is mainly because fish species distribution often covaries with other biotic and abiotic factors, complicating the study design. We tackled this issue in the northern part of the Jordan River system, in which a few fish species geographically overlap, across steep gradients of water temperature and salinity. Results: Using 16S rRNA metabarcoding, we studied the water properties that shape the skin bacterial communities, and their interaction with fish taxonomy. To better characterise the indigenous skin community, we excluded bacteria that were equally abundant in the skin samples and in the water samples, from our analysis of the skin samples. With this in mind, we found alpha diversity of the skin communities to be stable across sites, but higher in benthic loaches, compared to other fish. Beta diversity was found to be different among sites and to weakly covary with the dissolved oxygen, when treated skin communities were considered. In contrast, water temperature and conductivity were strong factors explaining beta diversity in the untreated skin communities. Beta diversity differences between co-occurring fish species emerged only for the treated skin communities. Metagenomics predictions highlighted the microbiome functional implications of excluding the water community contamination from the fish skin communities. Finally, we found that human-induced eutrophication promotes dysbiosis of the fish skin community, with signatures relating to fish health. Conclusions: Consideration of the background water microbiome when studying fish skin microbiomes, across varying fish species and water properties, exposes patterns otherwise undetected and highlight among-fish-species differences. We suggest that sporadic nutrient pollution events, otherwise undetected, drive fish skin communities to dysbiosis. This finding is in line with a recent study, showing that biofilms capture sporadic pollution events, undetectable by interspersed water monitoring.

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<p>Biochemical but not compositional recovery of skin mucosal microbiome communities after disruption</p>

Cited by 7 publications

References 32 publications

Monitoring disease and antibiotic treatment in the skin microbiota of farmed seabass fingerlings

Monitoring disease and antibiotic treatment in the skin microbiota of farmed seabass fingerlings

Monitoring Infection and Antibiotic Treatment in the Skin Microbiota of Farmed European Seabass (Dicentrarchus Labrax) Fingerlings

Dissecting the factors shaping fish skin microbiomes in a heterogeneous inland water system

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