2020
DOI: 10.2147/ott.s258631
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<p>Bone Marrow Stromal Antigen 2 is a Potential Unfavorable Prognostic Factor for High-Grade Glioma</p>

Abstract: Background: Bone marrow stromal antigen 2 (BST2) is considered as a transmembrane glycoprotein and plays essential roles in innate immunity. It has been recently reported that up-regulation of BST2 was associated with the development of breast carcinoma. However, the clinical significance of BST2 in glioma has not been identified. The purpose of the present study is to explore the expression pattern and the role of BST2 in the progression of high-grade glioma. Methods: Expression levels of BST2 were tested in … Show more

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Cited by 8 publications
(6 citation statements)
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“…CD317 was also described to induce the proliferation and migration of hepatocellular carcinoma, breast cancer, and some glioma cells. 19 , 22 , 23 In contrast to these findings, we did not observe a reduced proliferation or migration rate of LN-229 cells with a CD317 KO compared to CRISPR control or LN-229 WT cells ( Supplementary Figure S3B and C ).…”
Section: Resultscontrasting
confidence: 92%
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“…CD317 was also described to induce the proliferation and migration of hepatocellular carcinoma, breast cancer, and some glioma cells. 19 , 22 , 23 In contrast to these findings, we did not observe a reduced proliferation or migration rate of LN-229 cells with a CD317 KO compared to CRISPR control or LN-229 WT cells ( Supplementary Figure S3B and C ).…”
Section: Resultscontrasting
confidence: 92%
“…CD317 has been described to increase the proliferation and migration of hepatocellular carcinoma, breast cancer, and some glioma cell lines. 19 , 22 , 23 CD317 overexpression did not increase the proliferation of LN-229 cells in vitro and a knockout of CD317 did not reduce their tumorigenicity in vivo ( Supplementary Figure S3 and Figure 5B ). However, CD317 overexpression in the ZH-161 GIC model resulted in more aggressive tumors in vivo ( Figure 5C ).…”
Section: Discussionmentioning
confidence: 96%
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“…Glioma cell lines U87 and U373 were purchased from Shanghai Institute of Biochemistry and Cell Biology Chinese Academy of Sciences (Shanghai, China). Cells were cultured in RPMI-1640 medium containing 10% fetal bovine serum (FBS) and 1% penicillin-streptomycin at 37℃ in a humidified atmosphere with 5% CO 2 (Shi et al 2020).…”
Section: Cell Culture and Transfectionmentioning
confidence: 99%
“…These tumors are associated with a spectrum of neurological symptoms, depending on their location within the brain. Gliomas are known for their infiltrative nature, often making complete surgical removal challenging [ 2 ]. They encompass various subtypes, with glioblastoma (GBM) being one of the most aggressive and common forms.…”
Section: Introductionmentioning
confidence: 99%