&lt;p&gt;CELSR1 Acts as an Oncogene Regulated by miR-199a-5p in Glioma&lt;/p&gt;

Wang, Guang; Li, Yong; Zhang, Dongxia; Zhao, Songtao; Zhang, Qiong; Luo, Chao; Sun, Xiaochuan; Qian, Zhendong

doi:10.2147/cmar.s258835

Cited by 4 publications

(1 citation statement)

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“…Molecular distinctions between white matter and gray matter astrocytes identified in this study may enable insights into their unique developmental features and disease implications. For example, many genes enriched in “dense bulbous” astrocytes have been implicated in glioblastoma cell proliferation and invasion, such as ITGB4 ( 34 ), TMEM158 ( 35 ), MGMT ( 36 ), and CELSR1 ( 37 ), which could explain their remarkable migratory behavior. Detailed mapping of the developmental trajectories of these early astrocyte subtypes through the third trimester and into adulthood will be important to determine whether this astrocyte diversity is encoded at the level of progenitors or dynamically influenced by environmental cues present in distinct brain regions or cellular neighborhoods.…”

Section: Discussionmentioning

confidence: 99%

Fate mapping of neural stem cell niches reveals distinct origins of human cortical astrocytes

Allen

Donohue

Cadwell

et al. 2022

Science

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Progenitors of the developing human neocortex reside in the ventricular and outer subventricular zones (VZ and OSVZ, respectively). However, whether cells derived from these niches have similar developmental fates is unknown. By performing fate mapping in primary human tissue, we demonstrate that astrocytes derived from these niches populate anatomically distinct layers. Cortical plate astrocytes emerge from VZ progenitors and proliferate locally, while putative white matter astrocytes are morphologically heterogeneous and emerge from both VZ and OSVZ progenitors. Furthermore, via single-cell sequencing of morphologically defined astrocyte subtypes using Patch-seq, we identify molecular distinctions between VZ- derived cortical plate astrocytes and OSVZ- derived white matter astrocytes that persist into adulthood. Together, our study highlights a complex role for cell lineage in the diversification of human neocortical astrocytes.

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