&lt;p&gt;Central Sensitization-Related Changes in Brain Function Activity in a Rat Endometriosis-Associated Pain Model&lt;/p&gt;

Zheng, Ping; Jia, Shasha; Guo, Dalong; Chen, Sikai; Zhang, Wen; Cheng, Aoshuang; Xie, Weijie; Sun, Guibo; Leng, Jinhua; Lang, Jinghe

doi:10.2147/jpr.s232313

Cited by 12 publications

(15 citation statements)

References 49 publications

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“… 54–57 CS-related changes in functional brain activity can be observed in rats with endometriosis-related pain: enhanced ReHo signaling in the cingulate cortex, thalamus, and hippocampus, which may be due to neuronal apoptosis or hyperactivity. 58 In addition, since the brain-derived neurotrophic factor (BDNF) is an essential driver of neuroplasticity, targeting BDNF may be a potential therapeutic target for improving CS (blockade of the adenosine A2A receptor, antagonizing NMDA receptors, or blocking the proteinase-activated receptors 2-NK-κβ signaling pathway). 59 The importance of CS in chronic low back pain has been demonstrated.…”

Section: Discussionmentioning

confidence: 99%

Scientific Knowledge Graph and Trend Analysis of Central Sensitization: A Bibliometric Analysis

Li¹,

Xu²,

Fu³

et al. 2022

JPR

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Background Central sensitization refers to a state of hypersensitivity in the central nervous system and is associated with the development and maintenance of chronic pain. Central sensitization plays an essential role in various diseases. Nevertheless, there has been no bibliometric analysis before in this field. The purpose of this study was to provide critical themes and trends in the area of central sensitization, to build a network of knowledge, and to facilitate the future development of relevant basic and clinical research. Methods Publications on central sensitization were extracted from the Science Citation Index-Expanded. We used R software to systematically analyze the countries, institutions, authors, journals, references, and keywords of the publications. Besides, conceptual structure, intellectual structure, and social structure were constructed. Results A total of 4466 publications were included. Research in the field of central sensitization generally showed a steady upward trend. The three structural networks showed that the United States is the leading country in this field. Arendt-Nielsen L and Woolf CJ were the most productive and influential authors, respectively. “Pain” was the journal with the most studies. Most journals that published and cited articles about central sensitization were academically influential. Cluster analysis revealed that research in central sensitization contains three main conceptual clusters, and the themes of research evolve frequently. Current research focuses on the pathogenesis of central sensitization in neuropathic pain, the role of central sensitization in different diseases, and related clinical double-blind trials. Conclusion Central sensitization received widespread attention. The United States led the way in academic activity. In this field, the current situation of cooperation and communication between different countries and institutions is positive. The present research hotspots were the pathogenesis of central sensitization in neuropathic pain, the role of central sensitization in different diseases, and related clinical double-blind trials.

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Section: Discussionmentioning

confidence: 99%

Scientific Knowledge Graph and Trend Analysis of Central Sensitization: A Bibliometric Analysis

Li¹,

Xu²,

Fu³

et al. 2022

JPR

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“…recently, the prevalence of cPSP has been increasingly regarded as a public health problem; thus, the present study established SMir, simulating the state of cPSP in rats, to explore the potential mechanism of action of nicorandil in relieving pain. The astrocytes in the spinal cord are considered to be the key point for central sensitization (19,20), which is the main mechanism of pain induction (21)(22)(23). astrocytes in the cnS form a highly interconnected network via complexes formed by connexins, such as p120 and cx43 (5,24).…”

Section: Discussionmentioning

confidence: 99%

Effects of nicorandil on p120 expression in the spinal cord and dorsal root ganglion of rats with chronic postsurgical pain

Huang

Cao

et al. 2020

Mol Med Rep

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chronic postsurgical pain (cPSP) has a high incidence, but the underlying mechanism is not well understood. accumulating evidence has suggested that central sensitization is the main mechanism of pain. To study the role of p120 in cPSP, a skin/muscle incision and retraction (SMir) model was established, and immunofluorescence staining and western blotting were performed to analyze the expression of p120 in the spinal cord and dorsal root ganglion (drG). The results demonstrated that SMir increased the expression of p120 in the drG and the spinal cord compared with the naive group. Furthermore, it was demonstrated that p120 was mainly distributed in the glial fibrillary acidic protein-positive astrocytes in the spinal cord, and in the neurofilament 200-positive medium and large neurons in the drG. our previous studies have shown that adenosine triphosphate-sensitive potassium channel (KaTP) agonists can reduce postoperative pain in rats. Therefore, the changes in p120 were observed in the drG and spinal cord of rats following the intraperitoneal injection of nicorandil, a KaTP agonist. it was demonstrated that nicorandil administration could relieve mechanical pain experienced following SMir in rats, and decrease the expression of p120 in the drG and spinal cord. The results revealed that p120 may contribute to the prophylactic analgesic effect of nicorandil, thus providing a novel insight into the mechanism of cPSP prevention.

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“…148) were strongly expressed in the ACC, thalamus and hippocampus of rats with endometriosis-associated pain (Ref. 149). The formation of an immune oxidative environment within the hippocampus of endometriosis rats is one of the mechanisms leading to pain sensitisation, whereas the elevated oxidative state in the hippocampus was correlated with a lower level of BDNF (Refs 150, 151).…”

Section: Altered Brain In Endometriosismentioning

confidence: 99%

“…TRPV1 and NMDAR, modulating neuroplasticity and synaptic excitability (Ref. 148) were strongly expressed in the ACCpain (Ref 149)…”

mentioning

confidence: 99%

Unveil the pain of endometriosis: from the perspective of the nervous system

Fan

2022

Expert Rev. Mol. Med.

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Endometriosis is a chronic inflammatory disease with pelvic pain and uncharacteristic accompanying symptoms. Endometriosis-associated pain often persists despite treatment of the disease, thus it brings a deleterious impact on their personal lives as well as imposing a substantial economic burden on them. At present, mechanisms underlie endometriosis-associated pain including inflammatory reaction, injury, aberrant blood vessels and the morphological and functional anomaly of the peripheral and central nervous systems. The nerve endings are influenced by the physical and chemical factors surrounding the lesion, via afferent nerve to the posterior root of the spinal nerve, then to the specific cerebral cortex involved in nociception. However, our understanding of the aetiology and mechanism of this complex pain process caused by endometriosis remains incomplete. Identifying the pathogenesis of endometriosis is crucial to disease management, offering proper treatment, and helping patients to seek novel targets for the maintenance and contributors of chronic pain. The main aim of this review is to focus on every possible mechanism of pain related to endometriosis in both peripheral and central nervous systems, and to present related mechanisms of action from the interaction between peripheral lesions and nerves to the changes in transmission of pain, resulting in hyperalgesia and the corresponding alterations in cerebral cortex and brain metabolism.

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<p>Central Sensitization-Related Changes in Brain Function Activity in a Rat Endometriosis-Associated Pain Model</p>

Cited by 12 publications

References 49 publications

Scientific Knowledge Graph and Trend Analysis of Central Sensitization: A Bibliometric Analysis

Scientific Knowledge Graph and Trend Analysis of Central Sensitization: A Bibliometric Analysis

Effects of nicorandil on p120 expression in the spinal cord and dorsal root ganglion of rats with chronic postsurgical pain

Unveil the pain of endometriosis: from the perspective of the nervous system

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