&lt;p&gt;Circ_0057553/miR-515-5p Regulates Prostate Cancer Cell Proliferation, Apoptosis, Migration, Invasion and Aerobic Glycolysis by Targeting YES1&lt;/p&gt;

Zhang, Yang; Shi, Zhiyuan; Li, Zhijun; Wang, Xiaohui; Zheng, Pengyi; Li, Huibing

doi:10.2147/ott.s272294

Cited by 32 publications

(25 citation statements)

References 24 publications

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“…Deng et al claimed that the suppression of circ_0088233 reduced cell proliferation and induced G1 phase arrest and apoptosis through targeting hsa-miR-185-3p (Deng et al, 2020 ). Zhang et al indicated that the knockdown of circ_0057553 could inhibit cell viability and facilitate apoptosis (Zhang et al, 2020e ). Huang et al suggested that knockdown of circABCC4 inhibited tumor growth in vivo and cell-cycle progression in vitro by targeting miR-1182-FOXP4 regulatory axis (Huang et al, 2019a ).…”

Section: Resultsmentioning

confidence: 99%

The Emerging Role of Circular RNAs in Prostate Cancer: A Systematic Review

Wang

Zhang

Han

et al. 2021

Front. Cell Dev. Biol.

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Prostate cancer is one of the most common malignant tumors that threaten the health of men. It is urgent to explore new molecular targets and develop new drugs for the treatment of prostate cancer. Circular RNAs (circRNAs) are aberrantly expressed in various malignant tumors. The dysregulated circRNAs are involved in the metastasis, tumor growth, drug resistance, and immunosuppression of malignant tumors. The present review systematically summarized publications concerning the biological implications of circRNAs in prostate cancer. The PubMed and Web of Science databases were used to retrieve publications concerning circRNAs and prostate cancer until June 16, 2021. The following keywords were used in the literature search: (circRNA OR circular RNA) AND prostate cancer. 73 publications were enrolled in the present systematic review to summarize the role of circRNAs in prostate cancer. The dysregulated and functional circRNAs were involved in the cell cycle, proliferation, migration, invasion, metastasis, drug resistance and radiosensitivity of prostate cancer. In addition, circRNAs could function through EVs and serve as prognostic and diagnostic biomarkers. Certain circRNAs were correlated with clinicopathological features of prostate cancer. A comprehensive review of the molecular mechanism of the tumorigenesis and progression of prostate cancer may contribute to the development of new therapies of prostate cancer in the future.

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Section: Resultsmentioning

confidence: 99%

The Emerging Role of Circular RNAs in Prostate Cancer: A Systematic Review

Wang

Zhang

Han

et al. 2021

Front. Cell Dev. Biol.

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“…LINC00673 enhances breast cancer cell proliferation by miR-515-5p/MARK4 axis [ 28 ]. Circ_0057553/miR-515-5p signaling modulates glycolysis, invasion, migration, apoptosis, and proliferation of prostate cancer cells by regulating YES1 [ 29 ]. MiR-515-5p modulates migration of cancer cells by targeting MARK4 [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

Circular RNA circPIP5K1A contributes to cancer stemness of osteosarcoma by miR-515-5p/YAP axis

Shi

Guo

2021

J Transl Med

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Background Osteosarcoma is a common type of bone tumors and frequently occurs in children and adolescents. Cancer stem cells (CSCs) are a unique sub-type of self-renewal cancer cells and the stemness of cancer cells are involved in the spread, recurrence, metastasis, and even therapeutic resistance. However, the regulation mechanisms of CSCs in osteosarcoma are poorly understood. Circular RNA (circRNA) is a unique sort of non-coding RNAs and widely participate in the modulation of cancer progression. Methods In this study, we identified the critical function of circular RNA circPIP5K1A in stemness of osteosarcoma cells. Results CircPIP5K1A expression was significantly enhanced in clinical osteosarcoma tissues compared with the adjacent normal tissues. The depletion of circPIP5K1A by siRNA repressed osteosarcoma cell viabilities and induced osteosarcoma cell apoptosis. The suppression of circPIP5K1A attenuated the capabilities of invasion and migration of osteosarcoma cells. The circPIP5K1A knockdown increased E-Cadherin expression and decreased Vimentin expression in osteosarcoma cells. The sphere formation abilities of osteosarcoma cells were repressed by the depletion of circPIP5K1A. The CD133+CD44+ cell population of osteosarcoma cells was reduced by circPIP5K1A knockdown. The expression of ALDH1 and Nanog was decreased by the inhibition of circPIP5K1A in osteosarcoma cells. Mechanically, circPIP5K1A enhanced YAP expression by targeting miR-515-5p. MiR-515-5p inhibited stemness of osteosarcoma cells. The CSCs properties of osteosarcoma cells were repressed by circPIP5K1A knockdown or miR-515-5p mimic, while miR-515-5p inhibitor or YAP overexpression reversed circPIP5K1A knockdown-induced repression. Tumor xenograft analysis in nude mice demonstrated that the depletion of circPIP5K1A represses osteosarcoma cell growth in vivo. Conclusion In conclusion, we identified that circular RNA circPIP5K1A contributed to cancer stemness of osteosarcoma by miR-515-5p/YAP axis. Targeting circPIP5K1A may be considered as a potential therapeutic strategy for osteosarcoma treatment.

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“…It has been reported that CircSLC19A1 silencing inhibited PCa cell proliferation, migration and invasion by regulating miR-326/MAPK1 axis [18]. Zhang et al proposed that Circ_0057553 affected PCa cell viability, migration, invasion, apoptosis and glycolysis through miR-515-5p/YES1 axis [19]. Shan et al hold the view that circFMN2 promoted the proliferation of PCa cells by facilitating DNA synthesis and inhibiting cell apoptosis [20].…”

Section: Discussionmentioning

confidence: 99%

circITGA7 Acts As miR-370-3p Sponge to Suppress The Proliferation of Prostate Cancer

Guo¹,

Li²,

Wan³

et al. 2021

Preprint

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Objective: Prostate cancer (PCa) refers to one of the most common tumors in male’s genitourinary system. Emerging research has confirmed that circRNAs play an important role in the occurrence and development of tumors. However, the correlation between circular RNA circITGA7 and PCa still remains unclear. Here, the role of circITGA7 in PCa was explored and the underlying mechanism was investigated as well.Methods: The circRNA expression profiles in PCa and the paracancerous tissues were established by high-throughput sequencing. The expression levels of circITGA7 in PCa tissues and cells were detected by qRT-PCR. Cell Counting Kit-8, colony formation, EdU and flow cytometry assays were used to detect the effects of circITGA7 on PCa cell proliferation. To further explore the underlying mechanisms, bioinformatics analysis on downstream target genes was carried out. RNA immunoprecipitation and dual-luciferase reporter assays were used to verify the direct relationship between miR-370-3p and circITGA7 or P21CIP1.Results: circITGA7 was downregulated in PCa tissues and cells. Gain- or loss-of-function assays showed that circITGA7 inhibited the proliferation of PCa cells in vivo and in vitro. Mechanically, circITGA7 served as a sponge for miR-370-3p and miR-370-3p could target P21CIP1 in PCa cells. The inhibition of cell proliferation induced by circITGA7 could be reversed by transfecting miR-370-3p mimic. Conclusion: Our data indicated that circITGA7 played an important role in inhibiting tumor proliferation in PCa and might be a potential therapeutic target.

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<p>Circ_0057553/miR-515-5p Regulates Prostate Cancer Cell Proliferation, Apoptosis, Migration, Invasion and Aerobic Glycolysis by Targeting YES1</p>

Cited by 32 publications

References 24 publications

The Emerging Role of Circular RNAs in Prostate Cancer: A Systematic Review

The Emerging Role of Circular RNAs in Prostate Cancer: A Systematic Review

Circular RNA circPIP5K1A contributes to cancer stemness of osteosarcoma by miR-515-5p/YAP axis

circITGA7 Acts As miR-370-3p Sponge to Suppress The Proliferation of Prostate Cancer

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