&lt;p&gt;Clinical Significance of Diabetic Dermatopathy&lt;/p&gt;

Naik, Piyu Parth; Farrukh, Syed Nadir

doi:10.2147/dmso.s286887

Cited by 16 publications

(12 citation statements)

References 23 publications

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“…The diagnosis of diabetic dermopathy was confirmed by histopathological assessment. These dermoscopic features show an excellent correlation with histologic findings [1,2]. Thus, the greyish-white color of the central area probably corresponds to increased collagen density and fibroblastic proliferation, and the fine branching vessels probably are telangiectasias in the papillary dermis underlying an atrophic epidermis.…”

supporting

confidence: 56%

Dermoscopy of diabetic dermopathy

Navarro-Gilo¹,

Alberti²,

Gea³

et al. 2022

Dermatol Pract Concept

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supporting

confidence: 56%

Dermoscopy of diabetic dermopathy

Navarro-Gilo¹,

Alberti²,

Gea³

et al. 2022

Dermatol Pract Concept

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“…AGEs can bind with RAGE to activate NADPH oxidase (NOX), induce oxidative stress, and promote the inflammatory response ( 42 ). A large number of studies have shown that AGEs are involved in the occurrence and development of DDs, but many researchers have focused on keratinocytes and fibroblasts ( 6 ). There have been few studies on AGEs and skin macrophages.…”

Section: The Mechanism Of Macrophage-mediated Chronic Inflammatory In...mentioning

confidence: 99%

“…Some scholars believe that DD pathogenesis includes a local hyperglycaemic environment and the accumulation of glycation end products, growth factor starvation theory, microvascular damage, and excessive repair cell apoptosis ( 6 ). In recent years, with improvements in inspection technology, many scholars have begun to propose that subclinical skin inflammation (skin inflammation occurring in the absence of any visual inflammation) is a key link in promoting the occurrence and development of DDs ( 6 , 7 ). This concept has led to a reassessment of the triggers of DD development, focusing on the role of inflammation and poor immune system regulation in the pathogenesis of DDs.…”

Section: Introductionmentioning

confidence: 99%

Research progress on the mechanism by which skin macrophage dysfunction mediates chronic inflammatory injury in diabetic skin

et al. 2022

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Macrophages, the main immune cells in the skin, form an innate immune barrier. Under physiological conditions, skin maintains immune barrier function through macrophage phagocytosis and antigen presentation. Parenchymal and stromal cell regeneration plays an important role in skin injury repair and uses macrophage plasticity to influence and stabilize the skin microenvironment. Diabetic skin lesions are the most common diabetes complication and are involved in the early pathophysiology of diabetic foot. Therefore, studying the initial link in diabetic skin lesions is a research hot spot in the early pathogenesis of diabetic foot. Skin inflammation caused by hyperglycaemia, oxidative stress and other injuries is an important feature, but the specific mechanism is unknown. Recent studies have suggested that chronic inflammatory injury is widely involved in a variety of skin diseases, and whether it plays an important role in diabetic skin lesions is unclear. In this review, current research hotspots were combined with the pathogenesis of diabetic skin lesions and analysed from the perspectives of the physiological function of skin macrophages, the impairment of skin macrophages in diabetes, and the mechanism of chronic inflammatory injury in macrophages to provide a theoretical basis for early screening and evaluation of diabetic foot.

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“…4,12,15 This disorder typically does not need any treatment and will recover on its own in around 1-2 years. 16 The pathogenesis of necrobiosis lipoidica (NL) is unknown, but changes in microangiopathy and hypoxia may be to blame. Necrobiosis lipoidica affects 0.3% of patients with DM, and women tend to develop the disease.…”

Section: Diabetic Dermopathymentioning

confidence: 99%

“…The connection between granuloma annulare (GA) and DM is weaker than the one between NL and diabetes, 4 around 50% of NL patients have DM, 19 although single lesion can resolve spontaneously. 21 The skin lesions of GA are usually symmetrically distributed along the distal region of the extremities and sun-exposed skin, with skin-colored or red borders, 16 usually with an annular lesion. 19,21 The lesion may be generalized or localized; in diabetics, the generalized distribution appears to be more common and thought to be associated with diabetes.…”

Section: Skin Tagsmentioning

confidence: 99%

Potential skin problems of diabetes mellitus patients: a review

2022

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Diabetes mellitus (DM) is one of the common metabolic disorders, and a major part of chronic diseases, the prevalence of which tends to increase due to multifactor. Blood vessels, kidneys, lungs, and skin are among the organs that are affected. The first problem that arises, or commonly exists among one-third of diabetics, are problems with their skin, although skin lesions may develop along with the progress of the disease, or can occur during the later phase of DM. The prevalence and symptoms of skin problems in type 1 DM (T1DM) and type 2 DM (T2DM) are often unclear, and at the beginning of the course of the diseases they often go undiagnosed. Several theories regarding the pathophysiology of DM can be used as a logical reference for the early identification and diagnosis of skin problems, aimed at preventing the worsened condition. The use of skin autofluorescence (SAF) and AGEs reader in several cases of skin problems, can also be an important marker as an adjunct to predict the possibility and progressiveness of DM. Skin problems linked to patients with DM can be categorized as strongly related to diabetes, non-specific and related to DM, skin infection in DM, and skin problems due to diabetic medication. With the current COVID-19 pandemic, there are additional demands for more critical investigation of skin problems in patients with DM. The skin problems that occur in DM may need to be examined from the early stage and it is necessary to inhibit the progression of skin problems, as well as to consider the need for multidisciplinary DM therapy.

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<p>Clinical Significance of Diabetic Dermatopathy</p>

Cited by 16 publications

References 23 publications

Dermoscopy of diabetic dermopathy

Dermoscopy of diabetic dermopathy

Research progress on the mechanism by which skin macrophage dysfunction mediates chronic inflammatory injury in diabetic skin

Potential skin problems of diabetes mellitus patients: a review

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