&lt;p&gt;Clinically Meaningful Difference for the Infant Gastroesophageal Questionnaire Revised version (I-GERQ-R): A Quantitative Synthesis&lt;/p&gt;

Smith, Adam B.; Fawkes, Neil; Kotze, Helen L.; Hodgkinson, Victoria C.; Coyle, Cathal

doi:10.2147/prom.s238673

Cited by 5 publications

(3 citation statements)

References 20 publications

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“…It is not surprising that there is overlap between the results of these questionnaires based on similar symptom questions but this overlap in their diagnostic capabilities might significantly impact research findings and clinical practice. These instruments have been commonly used in pediatrics and the I‐GERQ‐R, in particular, has been utilized in numerous studies as a reflux‐specific outcome and in many ways has informed our understanding of reflux epidemiology and response to treatment in infants and young children (16–19,21–23,26–28). Our results call into question whether the I‐GERQ‐R is truly measuring reflux alone or if it is actually reflecting oropharyngeal dysphagia.…”

Section: Discussionmentioning

confidence: 99%

“…It has historically been used to both diagnose and monitor reflux symptom burden in epidemiologic and pivotal pharmacologic studies (17)(18)(19)(20)(21)(22)(23). With an abnormal cutoff above a score of 16 as signifying clinically significant GERD as validated against caregiver symptom reports, I-GERQ-R continues to be widely utilized for studies of reflux prevalence and clinical trial reporting (16,(24)(25)(26)(27)(28)(29).…”

Section: What Is Newmentioning

confidence: 99%

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Overlapping Symptoms of Gastroesophageal Reflux and Aspiration Highlight the Limitations of Validated Questionnaires

Duncan

DiFilippo²,

Kane³

et al. 2020

J. pediatr. gastroenterol. nutr.

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Objectives: Infants frequently present with feeding difficulties and respiratory symptoms, which are often attributed to gastroesophageal reflux but may be because of oropharyngeal dysphagia with aspiration. The Infant Gastroesophageal Reflux Questionnaire Revised (I-GERQ-R) is a clinical measure of gastroesophageal reflux disease but now there is greater understanding of dysphagia as a reflux mimic. We aimed to determine the degree of overlap between I-GERQ-R and evidence of dysphagia, measured by Pediatric Eating Assessment Tool-10 (Pedi-EAT-10) and videofluoroscopic swallow study (VFSS). Methods: We performed a prospective study of subjects <18 months old with feeding difficulties. All parents completed Pedi-EAT-10 and I-GERQ-R as a quality initiative to address parental feeding concerns. I-GERQ-R results were compared with Pedi-EAT-10 and, whenever available, results of prior VFSS. Pearson correlation coefficients were calculated to determine the relationship between scores. Groups were compared with 1-way ANOVA and Fisher exact test. ROC analysis was completed to compare scores with VFSS results. Results: One hundred eight subjects with mean age 7.1 ± 0.5 months were included. Pedi-EAT-10 and I-GERQ-R were correlated (r = 0.218, P = 0.023) in all subjects and highly correlated in the 77 subjects who had prior VFSS (r = 0.369, P = 0.001). The blue spell questions on I-GERQ-R had relative risk 1.148 (95% confidence interval [CI] 1.043–1.264, P = 0.142) for predicting aspiration/penetration on VFSS, with 100% specificity. Scores on the question regarding crying during/after feedings were also higher in subjects with abnormal VFSS (1.1 ± 0.15 vs 0.53 ± 0.22, P = 0.04). Conclusions: I-GERQ-R and the Pedi-EAT-10 are highly correlated. I-GERQ-R results may actually reflect oropharyngeal dysphagia and not just gastroesophageal reflux disease in infants.

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Section: Discussionmentioning

confidence: 99%

Section: What Is Newmentioning

confidence: 99%

Overlapping Symptoms of Gastroesophageal Reflux and Aspiration Highlight the Limitations of Validated Questionnaires

Duncan

DiFilippo²,

Kane³

et al. 2020

J. pediatr. gastroenterol. nutr.

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“…The gastroesophageal reflux disease questionnaire (GerdQ) is a self-report questionnaire that contains two reflux symptom-related positive questions, two gastrointestinal symptom-related negative questions, and two reflux symptom impact-related positive questions. 11 In our previous study, GerdQ demonstrated a high diagnostic value for predicting GERC at a cutoff point of 8.0, with a sensitivity of 66.7% and a specificity of 91.7%, compared with MII-pH. 12 Moreover, the GerdQ impact scale (GIS) has a score range of 0–6 and contains two reflux symptom impact-related positive and negative questions.…”

Section: Introductionmentioning

confidence: 99%

A comparison between a gastroesophageal reflux disease questionnaire-based algorithm and multichannel intraluminal impedance-pH monitoring for the treatment of gastroesophageal reflux-induced chronic cough

Li,

Zhang,

et al. 2024

Ther Adv Respir Dis

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Background: Empiric therapy with multichannel intraluminal impedance-pH monitoring (MII-pH) has been used for the initial treatment of gastroesophageal reflux-induced chronic cough (GERC). However, an algorithm based on the gastroesophageal reflux disease questionnaire (GerdQ) has the potential to achieve a simple, structured, and effective treatment approach for patients with GERC. Objectives: This study compared the efficacy of anti-reflux therapy based on GerdQ (new structured pathway, NSP) with medical treatment after MII-pH examination (ordinary clinical pathway, OCP) in the management of GERC. Design: For the NSP, we adapted the GerdQ score to establish the basis for a treatment algorithm. For the OCP, treatment was determined using the MII-pH examination results. Methods: The non-inferiority (NI) hypothesis was used to evaluate NSP versus OCP. Results: Overall, the NSP and OCP-based therapeutic algorithms have similar efficacy for GERC [NI analysis: 95% confidence interval (CI), −4.97 to 17.73, p = 0.009; superiority analysis: p = 0.420]. Moreover, the cough symptom scores and cough threshold improved faster in the NSP group than in the OCP group at week 8 ( p < 0.05). In the subgroup analyses using the GerdQ and GerdQ impact scale (GIS) scores, patients with low-likelihood GERC (GerdQ < 8) were more likely to benefit from OCP (NI analysis: 95% CI, −19.73 to 18.02, p = 0.213). On the other hand, in patients with high-likelihood and low-reflux impact GERC patients (GerdQ > 8 and GIS < 4), the NSP arm was not inferior to the standard treatment of OCP (NI analysis: 95% CI, −8.85 to 28.21%, p = 0.04; superiority analysis: p = 0.339), indicating that GerdQ- and GIS-guided diagnosis and management of patients with GERC could be an alternative to MII-pH management, especially in settings with reduced medical resources. Conclusions: The use of the GerdQ algorithm should be considered when handling patients with GERC in the primary care setting. Trial registration: This research was registered in the Chinese Clinical Trials Registry (ChiCTR-ODT-12001899).

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Diagnosis of GERD

van Wijk

2022

Gastroesophageal Reflux in Children

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<p>Clinically Meaningful Difference for the Infant Gastroesophageal Questionnaire Revised version (I-GERQ-R): A Quantitative Synthesis</p>

Cited by 5 publications

References 20 publications

Overlapping Symptoms of Gastroesophageal Reflux and Aspiration Highlight the Limitations of Validated Questionnaires

Overlapping Symptoms of Gastroesophageal Reflux and Aspiration Highlight the Limitations of Validated Questionnaires

A comparison between a gastroesophageal reflux disease questionnaire-based algorithm and multichannel intraluminal impedance-pH monitoring for the treatment of gastroesophageal reflux-induced chronic cough

Diagnosis of GERD

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