“…Transient IOP elevation commonly occurs after Schlemm's canal-related procedures, like canaloplasty and iStent, in primary open angle glaucoma (POAG), gonioscopy-assisted transluminal trabeculotomy (GATT) in childhood glaucoma, and penetrating canaloplasty in PACG. 19,29,[31][32][33][34] In addition to residual visco-agent, blood and inflammatory materials in Schlemm's canal can cause an early IOP spike. Failure of trabecular bypass procedures has been suggested to be due to atrophy of the collector channels secondary to persistent low aqueous outflow.…”