&lt;p&gt;Common and Unique Factors and the Bidirectional Relationship Between Chronic Kidney Disease and Nonalcoholic Fatty Liver in Type 2 Diabetes Patients&lt;/p&gt;

Lee, Yau-Jiunn; Wang, Chao-Ping; Hung, Wei‐Chin; Tang, Wei‐Hua; Chang, Yu‐Hung; Hu, Der-Wei; Lu, Yung‐Chuan; Yu, Teng‐Hung; Wu, Cheng‐Ching; Chung, Fu‐Mei; Hsu, Chia‐Chang

doi:10.2147/dmso.s237700

Cited by 18 publications

(19 citation statements)

References 45 publications

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“…NAFLD and CKD share similar pathological mechanisms, therefore they are speculated to have some links. The aforementioned mechanisms included the role of obesity, insulin resistance, the reninangiotensin system, and dysregulation of glucose metabolism and lipogenesis in the development of both disorders [17,44,45]. In this study, in line with the concept that NAFLD is the hepatic manifestation of the metabolic syndrome, the presence of NAFLD is associated with obesity and components of metabolic syndrome.…”

Section: Discussionsupporting

confidence: 63%

The Negative Association Between Non-alcoholic Fatty Liver Disease Severity and Gouty Nephropathy in a Non-diabetic Gouty Population: A Cross-Sectional Study

Zhou¹,

Wang²,

Chi³

et al. 2020

Preprint

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Background: Nonalcoholic fatty liver (NAFLD) and chronic kidney disease (CKD) share common pathogenic mechanisms and risk factors, but the specific relationship between NAFLD and gouty nephropathy has not been well understood. We aim to evaluate the association between NAFLD and gouty nephropathy in a non-diabetic gouty population.Methods: The retrospective cross‑sectional study was performed on 1049 non-diabetic gouty participants, who were hospitalized between 2014 and 2020, across 4 districts in Shandong, China. Demographic and clinical characteristics of the study population were collected. The odds ratios (OR) and corresponding 95% confidence intervals (CI) in relation to the NAFLD severity determined by ultrasonography were obtained by multiple logistic regression analysis. Results: An unexpectedly inverse relationship was found between NAFLD severity and the risk of gout nephropathy. Multivariate logistic regression analysis demonstrated that higher degree of NAFLD severity is independently associated with lower risk of gouty nephropathy, after adjusted for age, sex, smoking, gout duration, and metabolic risk factors including obesity, hypertension, hyperglycemia, hyperuriacemia and dyslipidemia, with OR 0.392 (95 % CI 0.248–0.619, P < 0.001), 0.379 (95 % CI 0.233–0.616, P < 0.001) and 0.148 (95 % CI 0.043–0.512, P = 0.003) in participants with mild, moderate, and severe NAFLD, respectively, compared to those without NAFLD. We also observed a weakened association of serum uric acid (SUA) with metabolic risk factors and NAFLD under circumstances of gouty nephropathy (r = -0.054, P = 0.466). Conclusions: The presence and severity of NAFLD was negatively associated with the risk of gouty nephropathy in the non-diabetic gouty populations. Further investigation of NAFLD will provide insights into the pathogenesis of gouty nephropathy.Trials registration: Chinese Clinical Trials Registry ChiCTR2000035185. Registered 2 August 2020.

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Section: Discussionsupporting

confidence: 63%

The Negative Association Between Non-alcoholic Fatty Liver Disease Severity and Gouty Nephropathy in a Non-diabetic Gouty Population: A Cross-Sectional Study

Zhou¹,

Wang²,

Chi³

et al. 2020

Preprint

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“…Lu et al reported that serum hepassocin concentrations are gradually increased in diabetic patients with NAFLD, and suggested that increased hepassocin levels might have clinical implications and could play a role as a biomarker for diabetes and NAFLD 25 . Our recent study showed that a bidirectional relationship existed between CKD and NAFLD in patients with type 2 diabetes mellitus 14 . Consistent with these findings, it was found in the present study that patients in the high hepassocin group were associated with increased rates of fatty liver and decreased eGFR.…”

Section: Discussionmentioning

confidence: 96%

“…In view of the fact that hepassocin causes hepatic steatosis and induces IR, and because CKD has a clear association with both hepatic steatosis and type 2 diabetes 14 , 15 , the authors postulated that hepassocin might be the link between these diseases. The aim of the present study was to clarify the clinical significance of circulating hepassocin levels in the context of fatty liver and renal function status.…”

Section: Introductionmentioning

confidence: 99%

Circulating hepassocin level in patients with stable angina is associated with fatty liver and renal function

Tsai¹,

Hung²,

Lu³

et al. 2021

Int. J. Med. Sci.

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Background: Chronic kidney disease (CKD) is a major risk factor for coronary artery disease and it is often associated with hepatic steatosis. Hepassocin (also known as hepatocyte-derived fibrinogen related protein or fibrinogen-like 1) is a novel hepatokine that causes hepatic steatosis and induces insulin resistance. However, the role of hepassocin in renal function status remains unclear. Our objective was to investigate the association of plasma hepassocin level with fatty liver and renal function status in patients with stable angina. Methods: Plasma hepassocin levels were determined by enzyme-linked immunosorbent assays in 395 consecutive patients with stable angina. Renal function was defined as an estimated glomerular filtration rate (eGFR). Fatty liver was defined by ultrasonography and fibrosis-4 (FIB-4) index. Results: With increasing hepassocin tertiles, patients had higher prevalence of fatty live, an increased waist-to-hip ratio, and neutrophil count, monocyte count, and FIB-4 index, higher levels of uric acid, blood urine nitrogen and higher sensitivity C-reactive protein. They also had incrementally lower eGFR, serum hemoglobin and albumin levels. In multiple linear stepwise regression analysis, only eGFR was significantly independent negatively associated with plasma hepassocin levels. Conclusion: Our results indicate that circulating hepassocin in patients with stable angina is associated with fatty liver and renal function, which suggests that increased plasma hepassocin may be involved in the pathogenesis of fatty liver and CKD.

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“…Accumulating data now suggest that the association between NAFLD and risk of prevalent CKD may be even bidirectional [145] . For example, in an observational study enrolling approximately 2,000 Taiwanese patients with T2DM, Lee et al [73] confirmed an independent association between imaging-diagnosed NAFLD and CKD (adjusted odds ratio 1.59, 95% confidence interval 1.12-2.25). Interestingly, when the authors performed a structural equation model analysis to test the effects of NAFLD on CKD and the potential role of CKD on NAFLD, they found the existence of a bidirectional relationship between NAFLD and CKD [73] .…”

Section: Increased Risk Of Ckd In Nafld Patients With T2dmmentioning

confidence: 97%

“…Indeed, the observational studies involving European or USA patients have reported a prevalence of NAFLD higher than that observed in the studies involving Asian patients. Additional factors that might explain these findings are different lifestyles (i.e., sedentary, physical inactivity), diets (i.e., high caloric diets, especially in the form of carbohydrates and Hamid et al [72] 203 Pakistani patients with T2DM diagnosed during the last 6 months were enrolled Mean age 53 years, 51% males Prevalence of NAFLD on US was 71.9% Lee et al [73] 1,992 Taiwanese patients with T2DM who participated in a disease management program at two specialized diabetes outpatient clinics. Mean age 66 years, mean BMI 26 kg/m 2 , 34% males Prevalence of NAFLD on US was 55.9%…”

Section: Prevalence Of Nafld In Patients With Diabetes Mellitusmentioning

confidence: 99%

Prevalence and incidence of intra- and extrahepatic complications of NAFLD in patients with type 2 diabetes mellitus

Mantovani¹,

Beatrice²,

Stupia³

et al. 2020

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Nonalcoholic fatty liver disease (NAFLD) is linked to abdominal obesity, insulin resistance and type 2 diabetes mellitus (T2DM). The association of NAFLD with T2DM is bidirectional. In fact, evidence suggests that abdominal obesity, T2DM and metabolic syndrome play a part in the development and progression of NAFLD. Alternatively, NAFLD is associated with an increased risk of having T2DM and metabolic syndrome. According to this background, it is unsurprising that patients with T2DM patients also have a higher prevalence of NAFLD than those with no T2DM, as well as an increased risk of developing liver-related and extrahepatic complications, mainly cardiovascular and renal diseases. Seeing the relationship of NAFLD with insulin resistance, obesity and T2DM, recent consensus proposes a change in nomenclature from NAFLD to metabolic associated fatty liver disease. In this review, we will discuss the prevalence and incidence of NAFLD (as detected by imaging techniques or liver biopsy) in patients with type T2DM with particular regard to hepatic and extrahepatic complications.

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<p>Common and Unique Factors and the Bidirectional Relationship Between Chronic Kidney Disease and Nonalcoholic Fatty Liver in Type 2 Diabetes Patients</p>

Cited by 18 publications

References 45 publications

The Negative Association Between Non-alcoholic Fatty Liver Disease Severity and Gouty Nephropathy in a Non-diabetic Gouty Population: A Cross-Sectional Study

The Negative Association Between Non-alcoholic Fatty Liver Disease Severity and Gouty Nephropathy in a Non-diabetic Gouty Population: A Cross-Sectional Study

Circulating hepassocin level in patients with stable angina is associated with fatty liver and renal function

Prevalence and incidence of intra- and extrahepatic complications of NAFLD in patients with type 2 diabetes mellitus

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