<p>Core–Shell Imidazoline–Functionalized Mesoporous Silica Superparamagnetic Hybrid Nanoparticles as a Potential Theranostic Agent for Controlled Delivery of Platinum(II) Compound</p>

Abstract

Introduction: As widely used chemotherapeutic agents, platinum compounds have several therapeutic challenges, such as drug resistance and adverse effects. Theranostic systems, macromolecular or colloidal therapeutics with companion diagnostics, not only address controlled drug delivery but also enable real-time monitoring of tumor sites. Methods: Synthesis of magnetic mesoporous silica nanoparticles (MMSNs) was performed for dual magnetic resonance imaging and drug delivery. MMSN surfaces were modified by imidazoline groups (MMSN-Imi) for cisplatin (Cis-Pt) conjugation via free N-termini to achieve wellcontrolled drug-release kinetics. Cis-Pt adsorption isotherms and drug-release profile at pH 5 and 7.4 were investigated using inductively coupled plasma atomic emission spectroscopy. Results: MMSN-Imi showed a specific surface area of 517.6 m 2 g −1 , mean pore diameter of 3.26 nm, and saturated magnetization of 53.63 emu/g. A relatively high r 2 /r 1 relaxivity value was obtained for MMSN-Imi. The nanoparticles provided high Cis-Pt loading with acceptable loading capacity (~30% w:w). Sustained release of Cis-Pt under acidic conditions led to specific inhibitory effects on the growth of human epithelial ovarian carcinoma cells, determined using MTT assays. Dual acridine orange-propidium iodide staining was investigated, confirming induction of apoptosis and necrotic cell death. Conclusion: MMSN-Imi exhibited potential for applications in cancer chemotherapy and combined imaging.

Mesoporous Silica Particles as Drug Delivery Systems—The State of the Art in Loading Methods and the Recent Progress in Analytical Techniques for Monitoring These Processes

“…PXRD is widely used for the MSNs characterization and there are many recent literature examples for its application. For example, to determine the crystalline structure of the magnetic nanoparticles before and after silica coating [ 228 ], or to confirm the presence of iron oxide and identify the relative crystalline phases formed in the synthesis of polymer grafted MSNs [ 229 ]. Further cases show the loading of indomethacin in an amorphous phase [ 230 ], and characterization of the mercapto-functionalized MCM-41 proving their stability after the modification process [ 222 ].…”

Green synthesis of iron-based nanoparticles using Chlorophytum comosum leaf extract: methyl orange dye degradation and antimicrobial properties

“…INPs have been intensively probed for the degradation and removal of organic wastes owing to their versatile properties, high catalytic activities, and highly reactive surface functional groups [13]. Environmental remediation [14], separations and analyses of various analysts [15,16], fungal, parasitic, and bacterial diseases therapies [17,18], drug delivery [19], biosensing [20], imaging [21], catalysis [22], and magnetic storage media [23] can be mentioned as some of the potential applications of NPs.…”

Microneedle Arrays Combined with Nanomedicine Approaches for Transdermal Delivery of Therapeutics

“…Nowadays, numerous NP formulations have been synthesized and explored for drug delivery to carry therapeutic agents, such as proteins, vaccines, and nucleic acids [ 90 , 91 , 92 ]. NPs exhibit numerous benefits, including unique size-dependent physicochemical properties [ 24 , 93 ], the protection of payload against chemical or proteolytic degradation, controlled release over prolonged times [ 94 ] as well as targeted delivery to specific parts of the body; hence, reducing the side effects [ 95 ].…”