<p>Correlation analysis of metabolic syndrome and its components with thyroid nodules</p>

Abstract

Objective This study aimed to analyze the relationship between the metabolic syndrome (MetS) and its components with the occurrence of thyroid nodules. Methods A total of 2719 volunteers from some areas of Gansu Province, China, who participated in the national survey of thyroid diseases and iodine nutrition status (Tide) and diabetes prevalence, were selected. Their height, weight, waist circumference (WC), systolic blood pressure (SBP), and diastolic blood pressure were recorded. The fasting plasma glucose (FPG), 2-h plasma postprandial glucose (2hPG), total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and glycosylated hemoglobin (HbA1C) levels were measured. The prevalence of MetS and thyroid nodules was evaluated, and the correlation between each component of MetS and thyroid nodules was studied. Results The prevalence of MetS and thyroid nodules was 15.4% and 17.2%, respectively. WC, SBP, body mass index, FPG, 2hPG, TG, TC, and thyroid-stimulating hormone levels were significantly higher in the thyroid nodule group. The prevalence of thyroid nodules was significantly higher in the MetS group. A positive correlation was found between the degree of metabolic disorder and the occurrence of thyroid nodules. WC was found to be a risk factor for the occurrence of thyroid nodules. For WC≥90 cm, an increase in the independent variables led to a significant rise in the incidence of thyroid nodules. Conclusion The prevalence of thyroid nodules was higher in the MetS group. The WC of the MetS components might be an independent risk factor for the occurrence of thyroid nodules.

Association of Changes in Metabolic Syndrome Status With the Incidence of Thyroid Nodules: A Prospective Study in Chinese Adults

“…Although several reports have demonstrated an association of MetS with TNs, they were mainly cross-sectional studies designed to evaluate either the prevalence of MetS in individuals with TNs vs. controls (12)(13)(14)(15), or, conversely, the prevalence of TNs in MetS patients (16,17). Meanwhile, related prospective studies are scarce.…”

Presencia de nódulos tiroideos en pacientes con síndrome metabólico en un hospital de tercer nivel de atención peruano

“…Estos hallazgos son congruentes con otros estudios. Jingfang Liu encontró un OR de 1,464 (IC 95 %: 1,01-2,122) para la presencia de nódulos tiroideos al tener tres componentes de SM en un modelo ajustado para edad y género [11] . Ayturk et al encontraron que la frecuencia de ENT en SM fue de 50,4 % [10] .…”

“…Se asumió una proporción de 60 % de pacientes con SM y ENT y un 20 % de pacientes sin SM ni ENT, basado en un estudio previo [11] , considerando un margen de error de 0,05 y un poder de 80 %, para realizar un análisis pareado de MacNemar, encontrándose 37 parejas para el análisis. Asumiendo una pérdida del 10 %, se analizaron 40 parejas pareadas por edad y género.…”

“…Encontraron además que la RI se asociaba con mayor prevalencia de nódulos tiroideos, siendo éste un factor que aumentaba la chance de aparición (odds ratio [OR]: 3,2) [10] . En la actualidad ya se tienen estudios que relacionan al SM con la ENT [11][12][13][14] .…”

Presence of Metabolic Syndrome and Thyroid Nodules in Subjects with Colorectal Polyps

“…Insulin resistance has also been considered to affect the pathogenesis of TNs [ 27 – 29 ]. Other risk factors, including waist circumference, HDL, and impaired fasting blood glucose levels, have also been associated with TNs [ 30 , 31 ].…”