<p>Cost-effectiveness analysis of baricitinib versus adalimumab for the treatment of moderate-to-severe rheumatoid arthritis in Spain</p>

Abstract

Background: Baricitinib is an oral janus kinase inhibitor for the treatment of rheumatoid arthritis (RA) and is approved in Europe for use in adults with moderately-to-severely active RA and an inadequate response or intolerance to conventional synthetic disease-modifying antirheumatic drug (csDMARD) therapy. To date, no economic evaluations have assessed the cost-effectiveness of baricitinib in the Spanish setting. Objectives: To evaluate the cost-effectiveness of baricitinib versus adalimumab for the treatment of moderately-to-severely active RA in the Spanish setting. Methods: A discrete event simulation model was developed in Microsoft Excel. Costs and outcomes were estimated over a lifetime horizon using the Spanish national payer perspective. The model compared baricitinib 4 mg once daily in combination with methotrexate with adalimumab 40 mg every other week in combination with methotrexate. Effectiveness and physical function were captured using the American College of Rheumatology criteria and the Health Assessment Questionnaire–Disability Index, input values of which were derived from a phase 3, double-blind, placebo- and active-controlled trial (RA-BEAM; funded by Eli Lilly and Incyte; ClinicalTrials.gov number, NCT01710358). Costs are presented in Euros, 2018 values. Results: In the base case analysis, baricitinib was associated with a quality-adjusted life year gain of 0.09 years over a lifetime horizon, at an incremental cost of –€558 versus adalimumab. Results of various scenario analyses and probabilistic sensitivity analysis generally were consistent with the base case analysis. Conclusion: This analysis suggests that baricitinib is a cost-effective treatment option compared to adalimumab for Spanish patients with moderately-to-severely active RA and a previous inadequate response or intolerance to csDMARD therapy.

JAK-Inhibitors for the Treatment of Rheumatoid Arthritis: A Focus on the Present and an Outlook on the Future

“…According to two pharmacoeconomic studies, baricitinib has been considered a cost-effective treatment for RA patients with a previous inadequate response or intolerance to cDMARD therapy compared to adalimumab [ 130 , 131 ]. The same result was confirmed in the analysis including the hypothetical discount scenario of market entry of adalimumab biosimilar [ 130 ].…”

“…According to two pharmacoeconomic studies, baricitinib has been considered a cost-effective treatment for RA patients with a previous inadequate response or intolerance to cDMARD therapy compared to adalimumab [ 130 , 131 ]. The same result was confirmed in the analysis including the hypothetical discount scenario of market entry of adalimumab biosimilar [ 130 ]. From a US budget analysis, baricitinib was considered an equally effective and less expensive option compared to other biologic (b)DMARDs in RA patients with an active disease and an inadequate response to previous anti-TNF agents [ 132 ].…”

Pharmacoeconomics of JAK inhibitors in patients with rheumatoid arthritis who had inadequate response to conventional synthetic disease- modifying antirheumatic drugs

“…При оценке QALY на основе частоты достижения ACR20, ACR50 и ACR70 рассчитывали снижение счета HAQ-DI (при достижении ACR20 -на 0,80, ACR50 -на 0,95, ACR70 -на 1,07) [5] c последующим пересчетом в показатель полезности. Изменение показателя полезности (качества жизни) рассчитывали по формуле ΔКЖ = −0,2102 × Δ HAQ [6].…”

Cost-Effectiveness of Baricitinib for Patients with Moderate-to-Severe Rheumatoid Arthritis After Methotrexate Failed in China

“…MTX relative to ADA ? MTX has not been assessed in China [19,20]. New agents often come with a financial burden, even though they might improve the clinical outcome for patients [21,22].…”