<p>Drug-release system of microchannel transport used in minimally invasive surgery for hemostasis</p>

Abstract

BackgroundSucrose allyl ether (SAE) containing hemostatic drugs and a photoinitiator was established to treat mild postpartum hemorrhage or long-term continuous abnormal uterine bleeding in minimally invasive surgery (MIS) using a photopolymerization method.Methods and resultsReal-time infrared spectroscopy and rheological experiments showed that the SAE monomer with shear-thinning characteristics could polymerize rapidly into a transparent membrane. Cytotoxicity experiments in vitro showed that this system could elicit a long-term hemostatic effect. Tissue adhesion was also evaluated. The photo-stability of four delivered antifibrinolytic drugs (6-aminocaproic acid, ethylenediaminediacetic acid, tranexamic acid and p-(aminomethyl) benzoic acid) was tested by ultraviolet-photolysis experiments and illustrated by time-dependent density functional theory. Sustained-release experiments revealed that the formed film could be used as a drug carrier. Molecular docking and molecular dynamics were done to investigate the binding mechanism between hemostatic drugs as ligands and the human plasminogen kringle-1 (1HPK) as a target.ConclusionIt has been suggested that SAE with tranexamic acid could be a drug-release system of microchannel transport used in MIS. This system could tackle the dilemma of fluidity and adhesion in MIS. The photo-stable tranexamic acid was the most suitable drug according to its satisfactory binding energy, good photo-stability, and sustained release.

Density Functional Theory Guide for an Allyl Monomer Polymerization Mechanism: Photoinduced Radical-Mediated [3 + 2] Cyclization

“…Our quantum chemistry calculation showed (Figure S1) that when a benzoyl radical from photocleavage of HMPP is added onto the double bond of AME, the addition rate constant ( k ) in the gas state is 4.6 × 10 –21 , one thousand times slower than k for addition to acrylate (2.2 × 10 –18 ) . However, in a previous study, we observed that SAE polymerization proceeded at a fairly rapid rate and formed a stable polymer, a phenomenon that is difficult to explain using the traditional FRA polymerization mechanism.…”

“…Bulter and Angelo asserted that the most important chain propagation pathway in diene polymerization is cyclization with cyclolinear polymer products. However, in our experience, polymeric products with high molecular weights were also obtained easily. , A noticeable monomer, sucrose allyl ether (SAE), was polymerized at room temperature using ultraviolet light, and the product (poly-SAE) was successfully applied in minimally invasive surgery as a hemostatic material.…”

Mechanistic insights into Smiles rearrangement. Focus on π–π stacking interactions along the radical cascade

“…This integration scheme has successfully been employed to address non-covalent binding energy in a ligand-target study. 35 Here, we used this approach at the quantum mechanical level of theory to assess the π-stacking between the oxindole and phenyl moieties along the reaction path. The electron sharing score (Δ𝑔 !…”