2020
DOI: 10.2147/idr.s269797
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<p>Drugs for Multiple Sclerosis Activate Natural Killer Cells: Do They Protect Against COVID-19 Infection?</p>

Abstract: COVID-19 infection caused by the newly discovered coronavirus severe acute respiratory distress syndrome virus-19 (SARS-CoV-2) has become a pandemic issue across the globe. There are currently many investigations taking place to look for specific, safe and potent anti-viral agents. Upon transmission and entry into the human body, SARS-CoV-2 triggers multiple immune players to be involved in the fight against the viral infection. Amongst these immune cells are NK cells that possess robust antiviral activity, an… Show more

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Cited by 21 publications
(16 citation statements)
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“…Particularly, the NK cell count reduction was more marked in patients with more severe COVID-19 disease compared to milder cases. Since NTZ induce an increase in circulating NK cells by reducing their migration into the CNS, it also may potentially represent an alternative treatment for COVID-19 [ 22 , 23 ].…”
Section: Discussionmentioning
confidence: 99%
“…Particularly, the NK cell count reduction was more marked in patients with more severe COVID-19 disease compared to milder cases. Since NTZ induce an increase in circulating NK cells by reducing their migration into the CNS, it also may potentially represent an alternative treatment for COVID-19 [ 22 , 23 ].…”
Section: Discussionmentioning
confidence: 99%
“…In fact, some hypothesized that DMTs may in fact be protective against COVID-19 by attenuating the cytokine-storm-like response [ 54 , 55 ]. Additionally, certain DMTs (i.e GA, fumaric acid, fingolimod) are associated with an increased expression of circulating natural killer cells possibly allowing for a better defense against COVID-19 [ 56 ]. These theories, though, are still purely speculative and subgroup analyses of different DMT therapies, albeit small in sample size, have yet to show protection from COVID-19 [ 17 , 20 , 53 ].…”
Section: Dmt and Infection Riskmentioning
confidence: 99%
“…DMF also upregulates CD56 bright NK cells, which, in turn, inhibits CD4 + and CD8 + IFN γ-producing T-cell populations, promoting an anti-inflammatory state and enhancing its beneficial effects in DMF-treated patients. 6 VZV can however cause a productive infection of human CD56 bright NK cells and upregulates surface expression of chemokine receptors associated with trafficking to the skin where highly infectious lesions develop. 7 The high number of CD56 bright NK cells noted in both our patients at the onset of skin rash might have facilitated the spread of VZV to the skin, producing such aggressive lesions unusual for young nonimmunosuppressed patients, requiring 6 weeks of antiviral therapy before resolution of skin lesions began.…”
Section: Discussionmentioning
confidence: 99%