&lt;p&gt;Dyslipidemia and Associated Factors Among Patients Suspected to Have &lt;em&gt;Helicobacter pylori&lt;/em&gt; Infection at Jimma University Medical Center, Jimma, Ethiopia&lt;/p&gt;

Abdu, Ahmedmenewer; Cheneke, Waqtola; Adem, Mohammed Edris; Belete, Rebuma; Getachew, Aklilu

doi:10.2147/ijgm.s243848

Cited by 21 publications

(26 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…On the other hand, the lowest prevalence of dyslipidemia of 5.2% was reported in a study from Ethiopia ( 13 ). The highest percentage of LDL-C data was reported in a study from Ethiopia (79.7%) ( 33 ) ( Table 1 ).…”

Section: Resultsmentioning

confidence: 84%

Determinants of Dyslipidemia in Africa: A Systematic Review and Meta-Analysis

Obsa

Ataro

Awoke

et al. 2022

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

BackgroundDyslipidemia is a common public health problem in Africa. It has emerged as an important cardiovascular risk factor. It has been steadily increasing due to economic growth, urbanization, and unhealthy dietary pattern. Therefore, it is essential to identify determinants of dyslipidemia to prevent the condition and reduce its long-term sequel.MethodsCombinations of search terms with Boolean operators were used to retrieve studies from PubMed, EMBASE, Cochrane Database, Cinahl, Scopus, Mednar, and Google Scholar. The methodological quality of each article was evaluated based on the 2017 Joanna Briggs Institute (JBI) Critical Appraisal checklist for prevalence studies. After evaluation of each study against these criteria, studies with a minimum score of 7 or above out of 9 JBI checklists were included. We included articles presented in the English language. The Cochrane Q test was used to assess the heterogeneity across studies. The visual assessment of publication bias was done by creating a funnel plot. The possible causes of heterogeneity were explored by subgroup analyses. Egger's weighted regression test was used to assess the presence of publication bias. Statistical analyses were done by using the STATA software version 14.ResultA total of 24 articles involving 37,902 participants from 10 African countries were included. The overall pooled prevalence of dyslipidemia was 52.8 (95% CI 40.8–64.9). Individuals with a body mass index (BMI) >25.0 kg/m2 and waist circumference (WC) >94 cm were, respectively, 2.36 (95% CI (1.33–4.18), p < 0.001) and 2.33 (95% CI (0.75–0.29) p < 0.001) times more likely to develop dyslipidemia than those with lower values. Furthermore, patients with diabetes mellitus (DM) and hypertension (HTN) were 2.32 (95% CI (0.89–6.05) p < 0.001) and 2.05 (95% CI (1.31–3.21), p < 0.001) times more likely to present with dyslipidemia than non-diabetic patients and those without HTN.ConclusionThis study revealed that the prevalence of dyslipidemia is relatively high among study participants in African countries and the independent predictors of dyslipidemia were BMI >25.0 kg/m2, WC > 94 cm, raised blood glucose level, and raised blood pressure. Therefore, there should be a pressing public health measure to prevent, identify, and treat dyslipidemia with the special emphasis on obese, diabetic, and hypertensive patients.

show abstract

Section: Resultsmentioning

confidence: 84%

Determinants of Dyslipidemia in Africa: A Systematic Review and Meta-Analysis

Obsa

Ataro

Awoke

et al. 2022

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

show abstract

“… 23 , 24 But, in contrast with studies done in Jimma and Iraq. 14 , 18 We have found that serum HDL levels of H. pylori- positive dyspeptic patients (37.54 ± 7.98 mg/dL) were significantly lower than negative dyspeptic patients (43.117 ± 7.858 mg/dL). A similar result was reported in studies conducted in Iraq and a meta-analysis was done in Japan.…”

Section: Discussionmentioning

confidence: 92%

“…An altered lipid profile, including an increased LDL level and decreased HDL level, is one of the most important risk factors for atherosclerotic disease. 14 …”

Section: Introductionmentioning

confidence: 99%

Evaluation of Lipid Profile and Inflammatory Marker in Patients with Gastric Helicobacter pylori Infection, Ethiopia

GB¹,

Menon²,

Gizaw³

et al. 2022

IJGM

View full text Add to dashboard Cite

Introduction H. pylori are gram-negative, microaerophilic helical-shaped bacteria with multiple flagella and commonly exist in the stomach. This infection may cause significant mucosal inflammation and damage, leading to ulcers in the stomach. It can also affect organ systems external to the gastrointestinal tract. To assess cardiovascular risk factors and to predict cardiovascular disorders, we are evaluating and comparing lipid profile and inflammatory marker between H. pylori- positive and negative patients. Objective To evaluate and compare lipid profile (TC; TG; LDL; HDL) and inflammatory marker (hs-CRP) in dyspeptic patients with and without H. pylori infection. Methods Comparative cross-sectional study was conducted from September 2020 to January 2021 at Debre Markos Referral Hospital, Debre Markos Health Center, and Hidassie Health Center, Ethiopia. Each of 50 H. pylori -positive and negative dyspeptic patients were studied. The data were checked for completeness and analyzed by SPSS version 25.0 Software. A p-value < 0.05 was considered statistically significant. Results Serum mean high-density lipoprotein (HDL) values were 37.54 ± 7.98 mg/dL and 43.12 ± 7.86 mg/dL (p < 0.05) for H. pylori -positive and negative dyspeptic patients, respectively, and median serum high sensitive C reactive protein (hs-CRP) levels were 6.29 mg/L (1.66–41.34) and 3.35 mg/L (0.39–10.01) (p < 0.05) for H. pylori -positive and negative dyspeptic patients, respectively. Conclusion H. pylori infection significantly alters serum high-density lipoprotein (HDL) and high sensitive C reactive protein (hs-CRP) levels in dyspeptic patients, as a result, increase the potential risk of cardiovascular diseases.

show abstract

“…Patients suffering of H. pylori infection are prone to display an unfavorable pro-atherogenic lipid profile featured by high triglycerides, total cholesterol and LDL-C and decreased HDL-C levels (22,(66)(67)(68)(69). Zhao et al, found that, in addition to the dyslipidemic profile, bilirubin levels were also diminished in H. pylori infected patients (70).…”

Section: H Pylori Infection and Metabolic Diseasesmentioning

confidence: 99%

Gut Microbiota: The Missing Link Between Helicobacter pylori Infection and Metabolic Disorders?

et al. 2021

View full text Add to dashboard Cite

Helicobacter pylori (H. pylori) is a gram-negative bacterium that infects approximately 4.4 billion individuals worldwide. Although the majority of infected individuals remain asymptomatic, this bacterium colonizes the gastric mucosa causing the development of various clinical conditions as peptic ulcers, chronic gastritis and gastric adenocarcinomas and mucosa-associated lymphoid tissue lymphomas, but complications are not limited to gastric ones. Extradigestive pathologies, including metabolic disturbances such as diabetes, obesity and nonalcoholic fatty liver disease, have also been associated with H. pylori infection. However, the underlying mechanisms connecting H. pylori with extragastric metabolic diseases needs to be clarified. Notably, the latest studies on the topic have confirmed that H. pylori infection modulates gut microbiota in humans. Damage in the gut bacterial community (dysbiosis) has been widely related to metabolic dysregulation by affecting adiposity, host energy balance, carbohydrate metabolism, and hormonal modulation, among others. Taking into account that Type 2 diabetic patients are more prone to be H. pylori positive, gut microbiota emerges as putative key factor responsible for this interaction. In this regard, the therapy of choice for H. pylori eradication, based on proton pump inhibitor combined with two or more antibiotics, also alters gut microbiota composition, but consequences on metabolic health of the patients has been scarcely explored. Recent studies from our group showed that, despite decreasing gut bacterial diversity, conventional H. pylori eradication therapy is related to positive changes in glucose and lipid profiles. The mechanistic insights explaining these effects should also be addressed in future research. This review will deal with the role of gut microbiota as the linking factor between H. pylori infection and metabolic diseases, and discussed the impact that gut bacterial modulation by H. pylori eradication treatment can also have in host’s metabolism. For this purpose, new evidence from the latest human studies published in more recent years will be analyzed.

show abstract

<p>Dyslipidemia and Associated Factors Among Patients Suspected to Have <em>Helicobacter pylori</em> Infection at Jimma University Medical Center, Jimma, Ethiopia</p>

Cited by 21 publications

References 33 publications

Determinants of Dyslipidemia in Africa: A Systematic Review and Meta-Analysis

Determinants of Dyslipidemia in Africa: A Systematic Review and Meta-Analysis

Evaluation of Lipid Profile and Inflammatory Marker in Patients with Gastric Helicobacter pylori Infection, Ethiopia

Gut Microbiota: The Missing Link Between Helicobacter pylori Infection and Metabolic Disorders?

Contact Info

Product

Resources

About