&lt;p&gt;Dyslipidemia and Its Associated Risk Factors Among Adult Type-2 Diabetic Patients at Jimma University Medical Center, Jimma, Southwest Ethiopia&lt;/p&gt;

Haile, Kassahun; Timerga, Abebe

doi:10.2147/dmso.s283171

“…Dyslipidemia is a common phenomenon in type-2 diabetic patients characterized by an abnormal lipid profile because insulin resistance or deficiency affects key enzymes and pathways in lipid metabolism [9,10]. Globally, the prevalence of dyslipidemia is gradually increasing (�80% to 90%) in developing countries like Ethiopia [11], Kenya [12], Sri Lanka [13], India [14], and Bangladesh [15,16]. Cardiovascular risk is significantly increased among patients with diabetes by the presence of dyslipidemia [7].…”

Section: Introductionmentioning

confidence: 99%

“…Globally, several community-based studies found that blood pressure, fasting blood glucose, BMI, age, poor physical activity, dietary habits, smoking/tobacco use, and other lifestyle changes have contributed as the major risk factors for increasing the prevalence of dyslipidemia among T2DM patients [11,16,[19][20][21]. For example, in some Asian countries, several studies observed a rising trend in the prevalence of dyslipidemia and other metabolic syndromes in T2DM patients [13,[22][23][24][25].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of dyslipidemia and associated risk factors among newly diagnosed Type-2 Diabetes Mellitus (T2DM) patients in Kushtia, Bangladesh

Ahmmed

¹

,

Shuvo²,

Paul

³

et al. 2021

PLOS Glob Public Health

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Dyslipidemia is considered a significant modifiable risk factor for type-2 diabetes mellitus (T2DM) and has become one of the emerging health problems throughout the world. In Bangladesh, data on dyslipidemia among newly diagnosed T2DM patients are comparatively inadequate. This study aimed to evaluate the prevalence of dyslipidemia and its associated risk factors in newly diagnosed T2DM patients. This cross-sectional study was conducted by a well-structured questionnaire from 132 newly diagnosed type-2 diabetic patients attending the Mujibur Rahman Memorial Diabetic Hospital in Kushtia, Bangladesh. Data regarding socio-demographic, anthropometric, fasting blood glucose, total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL), and low-density lipoprotein (LDL) were collected from all the respondents. The association between dyslipidemia and its associated factors was analyzed using the multivariate logit regression model. The findings suggest that the prevalence rate of dyslipidemia was 75.7% in female and 72.6% in male T2DM patients. The odds of having dyslipidemia were 1.74 (95% Cl: 1.58–1.87) times significantly higher in female (p<0.001). The other factors associated with dyslipidemia encompassed age between 30–39 years (OR: 2.32, 95% CI: 1.97–2.69), obesity (OR: 2.63, 95% CI: 2.27–2.90), waist circumferences of male ≥90 and female ≥80 (OR: 1.65, 95% CI: 1.59–1.89), hypertensive patients (OR: 1.51, 95% CI: 1.45–1.74), physically inactive (OR: 3.25, 95% CI: 1.84–4.68), and current smoker or tobacco user (OR: 1.93, 95% CI: 1.85–2.13). This study concluded that the high prevalence of dyslipidemia was found among newly diagnosed type-2 diabetes patients and associated with gender, age, BMI, waist circumference, poor physical activity, and smoking, or tobacco use. This result will support increase awareness of dyslipidemia and its associated risk factors among type-2 diabetes patients.

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“…Evidences revealed that poor nutritional knowledge, inadequate dietary practice, low level of physical activity [21], obesity [21,22], poor glycemic control [23], being hypertensive [21][22][23], old age [21,22], low education status [21], and duration of DM [22,23] were significant predictors of dyslipidemia among people living with DM.…”

Section: Introductionmentioning

confidence: 99%

Hypertriglyceridemia and Other Plasma Lipid Profile Abnormalities among People Living with Diabetes Mellitus in Ethiopia: A Systematic Review and Meta-Analysis

Dagnew

¹

,

Yeshaw

²

,

Geremew

³

et al. 2021

BioMed Research International

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Background. Dyslipidemia is one of the leading causes of cardiovascular complications in diabetes mellitus (DM) patients. Though it is a major public health problem in Ethiopia, there is no a nation-wide study to determine dyslipidemia among DM patients yet. Therefore, this systematic review and meta-analysis intended to estimate the prevalence of hypertriglyceridemia and other plasma lipid abnormalities among people living with DM in Ethiopia. Methods. We systematically searched PubMed, Google Scholar, African Journals Online, Hinari, and direct Google. Studies conducted until May 9, 2020, that reports the prevalence of dyslipidemia among people living with DM were included. The DerSimonian and Laird random-effects model was used to determine the pooled prevalence of lipid profile abnormalities. Heterogeneity was checked using the I 2 statistic, whereas publication bias was tested by funnel plot and Egger’s test. Besides, subgroup and sensitivity analyses were performed. Results. We used 18 primary studies, including 4961 participants living with DM, which met the eligibility criteria for the meta-analysis of hypertriglyceridemia. The estimate of hypertriglyceridemia (≥150 mg/dl) was 48.15% (95% CI: 38.15-58.15, I 2 = 98.4 % ) after performing the main meta-analysis using the random-effects model. The subgroup analysis showed a higher pooled estimate of hypertriglyceridemia among T2DM (57.80% (95% CI: 50.50-65.10), I 2 = 92.5 % ), studies that used probability sampling technique (59.09% (95% CI: 43.58-74.59), I 2 = 98.6 % , p < 0.001 ), and studies from primary data sources (51.43% (95% CI: 40.72-62.13), I 2 = 98.0 % , p < 0.001 ). Moreover, the estimated pooled prevalence of the total plasma cholesterol ( TC ≥ 200 mg / dl ) was 34.08% (95% CI: 28.41-39.75, I 2 = 92.4 % ), LDL − C ≥ 100 mg / dl was 41.13% (95% CI: 27.15-55.11, I2 = 98.8%), and HDL ≤ 40 mg / dl for men and ≤ 50 mg / dl for women was 44.36% (95% CI: 31.82-56.90, I 2 = 98.8 % ). Conclusions. The pooled prevalence of hypertriglyceridemia and other lipid abnormalities among DM patients was relatively high in Ethiopia. It strongly suggests the need to give maximal attention to the adherence of DM management to reduce the circulatory lipid profile abnormalities and subsequent complications. Prospero Registration. CRD42020182291.

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“…BMI body mass index, CI confidence interval, HR hazard ratio, IQR interquartile ratio, KM Kaplan-Meier, T2DM type 2 diabetes mellitus the group who visited the hospital earlier may also be due to the earlier finding of hyperglycemia during patient visits for the treatment of comorbidities. The presence of hypertension and dyslipidemia has been reported to increase the risk of T2DM [18,19]. However, despite the high prevalence of hypertension and dyslipidemia, subsequent antidiabetic treatment after an early visit (for the treatment of diabetes) was delayed.…”

Section: Resultsmentioning

confidence: 99%

A Claims-Based Cohort Study on the Treatment Patterns of Japanese Patients with Type 2 Diabetes Mellitus and the Association of Early First Physician Visit with Time to Prescription of Oral Hypoglycemic Agents

Watada

¹

,

Kawakita

²

,

Tanaka

³

et al. 2021

Diabetes Ther

1

0

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Introduction: This study aimed to investigate the relationships between timing of the first physician visit after detection of an abnormal glycated hemoglobin (HbA1c) value at routine annual check and the time to antidiabetic treatment prescription; and understand treatment patterns in patients newly diagnosed with type 2 diabetes mellitus (T2DM). Methods: This retrospective, longitudinal, observational cohort study examined data from JMDC Inc., an administrative claims database. Patients with HbA1c value of at least 6.5% at routine annual check, aged 20 years or older, and prescribed at least one antidiabetic drug were included. This cohort was classified into early physician visit and delayed physician visit groups based on the timing of the first physician visit relative to the median. Patients were monitored from the date of first HbA1c checkup of at least 6.5% to the date of first physician visit with an HbA1c test, and from the date of the first physician visit to the date of prescription of first-line and second-line T2DM treatments. The time to first prescription of antidiabetic treatment for the two groups was then compared. Results: Of 4798 eligible patients, 54.8% were prescribed first-line T2DM therapy less than 2 months from the first physician visit for T2DM diagnosis. A lower percentage of the early group compared with the delayed group required T2DM pharmacological therapy in less than 2 months (46.1% vs. 63.4%). The early group had a longer median time to prescription of first-line therapy [92 days vs. 15 days, p \ 0.0001; hazard ratio (HR) 1.31, 95% confidence interval (CI) 1.24, 1.39] and second-line therapy (1599 days vs. 1315 days, p \ 0.0001; HR 1.22, 95% CI 1.11, 1.34) compared with the delayed group. Conclusion:In Japanese patients with T2DM, early physician visit after abnormal HbA1c detection at routine annual check is associated with a longer period before T2DM medication requirement, and may improve disease course.

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<p>Dyslipidemia and Its Associated Risk Factors Among Adult Type-2 Diabetic Patients at Jimma University Medical Center, Jimma, Southwest Ethiopia</p>

Cited by 41 publications

References 27 publications

Prevalence of dyslipidemia and associated risk factors among newly diagnosed Type-2 Diabetes Mellitus (T2DM) patients in Kushtia, Bangladesh

Prevalence of dyslipidemia and associated risk factors among newly diagnosed Type-2 Diabetes Mellitus (T2DM) patients in Kushtia, Bangladesh

Hypertriglyceridemia and Other Plasma Lipid Profile Abnormalities among People Living with Diabetes Mellitus in Ethiopia: A Systematic Review and Meta-Analysis

A Claims-Based Cohort Study on the Treatment Patterns of Japanese Patients with Type 2 Diabetes Mellitus and the Association of Early First Physician Visit with Time to Prescription of Oral Hypoglycemic Agents

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