&lt;p&gt;Effect of intrathecal dexmedetomidine on cesarean section during spinal anesthesia: a meta-analysis of randomized trials&lt;/p&gt;

Wang, Yunqi; Zhang, Xian-Jie; Wang, Ying

doi:10.2147/dddt.s207812

Cited by 19 publications

(21 citation statements)

References 29 publications

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“…It has been found to promote the metabolism of kidney and liver and effectively reduce the adverse reactions caused by stress. Furthermore, it had a good sedative effect and preserves consciousness while not causing respiratory depression in patients [ 24 ]. Both extubation and intubation can positively affect patients with acute abdomen.…”

Section: Discussionmentioning

confidence: 99%

Reconstruction Algorithm-Based Ultrasonic and Spiral CT Images in Evaluating the Effects of Dexmedetomidine Anesthesia for Acute Abdomen

Tian¹,

Zhang

Guo³

2021

Computational and Mathematical Methods in Medicine

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Objective. The study focused on the application value of iteration reconstruction algorithm-based ultrasound and spiral computed tomography (CT) examinations, and the safety of dexmedetomidine anesthesia in acute abdominal surgery. Methods. 80 cases having the acute abdomen surgery were selected as the research subjects. They were divided into group A (40 cases) and group B (40 cases) according to the anesthetic drugs used in the later period. The experimental group was injected with propofol, remifentanil, and atracurium combined with dexmedetomidine; the control group was injected with propofol, remifentanil, and atracurium only. After the operation, the patient was for observed for the pain, agitation, adverse reactions, heart rate (HR), and blood pressure. All patients received ultrasound and spiral CT examinations, and based on the characteristics of the back-projection algorithm, an accelerated algorithm was established and used to process the image, and according to which, the patient’s condition and curative effects were evaluated. Results. After image reconstruction, the ultrasound and spiral CT images were clearer with less noise and more prominent lesions than before reconstruction. Before image reconstruction, the accuracy rates of ultrasound and spiral CT in diagnosing acute abdomen were 92.3% and 91.1%, respectively. After reconstruction, the corresponding numbers were 96.3% and 98.1%, respectively. After reconstruction, the accuracy of the two methods in diagnosing acute abdomen was significantly improved compared with that before reconstruction, and the difference was statistically significant ( P < 0.05 ). The Ramsay score of the experimental group was significantly higher than that of the control group at each time period, P < 0.05 ; the agitation score and visual analogue scale (VAS) score of the experimental group were significantly lower than the control group at each time period after waking up, P < 0.05 . Conclusion. Reconstruction algorithm-based ultrasound and spiral CT images have high application value in the diagnosis of patients with acute abdomen, and dexmedetomidine has good safety in anesthesia surgery.

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Section: Discussionmentioning

confidence: 99%

Reconstruction Algorithm-Based Ultrasonic and Spiral CT Images in Evaluating the Effects of Dexmedetomidine Anesthesia for Acute Abdomen

Tian¹,

Zhang

Guo³

2021

Computational and Mathematical Methods in Medicine

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“…Dexmedetomidine, as a highly selective α‐2 adrenergic receptor agonist, can effectively attenuate noradrenergic effects by inhibiting the binding of α‐2 presynaptic adrenergic receptors to the locus coeruleus in the brain. Dexmedetomidine can be administered both intravenously and intrathecally in obstetric anaesthesia 16–18 to optimize anaesthesia, reduce intraoperative stress and adverse reactions and ensure the safety of the infant and breastfeeding 7,19 . In addition, it has certain organ protective effects in subjects with preeclampsia, pulmonary hypertension in pregnancy and hyperthyroidism 20–23 .…”

Section: Discussionmentioning

confidence: 99%

Effect of dexmedetomidine on oxytocin‐induced uterine contraction during optimal caesarean section anaesthesia

Zhang

et al. 2022

Basic Clin Pharma Tox

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Numerous drugs are used during caesarean sections to provide regional and general anaesthesia. Dexmedetomidine has been used in some recent obstetric trials, but there are concerns about postpartum changes in uterine contractions. This study evaluated the effect of dexmedetomidine on oxytocin-induced uterine contractions in women undergoing caesarean section. Sixty women undergoing caesarean section in Lianyungang Second People's Hospital were randomly assigned to dexmedetomidine (group D, n = 30) or saline (group C, n = 30) groups. Equal volumes of saline or dexmedetomidine were administered intravenously (IV). During the intraoperative delivery of the foetus and placenta, oxytocin was administered to promote contractions. Heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean arterial

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“…Dexmedetomidine can reduce the use of opioids during cesarean delivery reducing the risk of nausea and vomiting. Also in the postoperative period it have an opioid sparing effect reducing rescue dose of opioid and analgesic [19]. Intrathecal dexmedetomidine during cesarean section appears safe both for the mother and for the fetus.…”

Section: Discussionmentioning

confidence: 99%

Anesthesiologic management of pregnant women with SARS-COV-2 infection undergoing cesarean delivery

Coviello,

Posillipo,

Golino

et al. 2021

Clin. Exp. Obstet. Gynecol.

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Background: Pregnant women are usually more susceptible to infection due to typical physiological and mechanical changes, such as increased heart rate, stroke volume and pulmonary residual capacity. The aim of this study was to evaluate an innovative anesthesiologic opioid-free management protocol in symptomatic pregnant women, with COVID-19 and with oxygen therapy, undergoing cesarean delivery with spinal anesthesia. Methods: With the patient in the sitting position, spinal anesthesia was performed at the L1-L2 level. Vertebral level has been identified starting from the sacrum, we counted the laminae in the caudal-to-cephalad direction, which was then marked with a surgical pen. The technique was performed in asepsis, in the subarachnoid space a ter vision of clear Cephalo-Spinal Fluid (CSF) in the spinal needle 27 Gauge, without letting out the CSF, bupivacaine 0.5% 10 mg, dexmedetomidine 10 µg and dexamethasone 4 mg was injected. Results: During the study period, 40 pregnant women with one or more symptoms and supplemental oxygen (FiO2 35-40%) who underwent cesarean delivery were included in the study. All pregnant women had pain visual analog scale (VAS) ≤3, and no pregnant women required rescue dose. Adverse e fects, such as nausea, vomiting, shivering, or pruritus were not recorded in any case. A ter a mean of 2.5 hours from the spinal anesthesia, all the included women had a complete motility of the lower limbs and were able to mobilize independently within 12 hours a ter delivery. Mean time to first latus was about 8 hours a ter delivery. Conclusions: Pregnant women in COVID-19 can safely receive intrathecal dexamethasone and dexmedetomidine during planned cesarean delivery.

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<p>Effect of intrathecal dexmedetomidine on cesarean section during spinal anesthesia: a meta-analysis of randomized trials</p>

Cited by 19 publications

References 29 publications

Reconstruction Algorithm-Based Ultrasonic and Spiral CT Images in Evaluating the Effects of Dexmedetomidine Anesthesia for Acute Abdomen

Reconstruction Algorithm-Based Ultrasonic and Spiral CT Images in Evaluating the Effects of Dexmedetomidine Anesthesia for Acute Abdomen

Effect of dexmedetomidine on oxytocin‐induced uterine contraction during optimal caesarean section anaesthesia

Anesthesiologic management of pregnant women with SARS-COV-2 infection undergoing cesarean delivery

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