&lt;p&gt;Effect of Rikkunshito, a Traditional Japanese Herbal Medicine, on Delayed Gastric Emptying and Oral Dietary Intake After Pancreaticoduodenectomy: A Prospective, Randomized, Single-Center, Open-Labeled Study&lt;/p&gt;

Yamaguchi, Hiroshi; Kimura, Yasutoshi; Imamura, Masafumi; Nagayama, Masatoshi; Itô, Tatsuya; Kyuno, Daisuke; Kono, Tsuyoshi; Kimura, Akina; Akizuki, Emi; Nishidate, Toshihiko; Okita, Kenji; Nobuoka, Takayuki; Mizuguchi, Toru; Hirata, Koichi; Takemasa, Ichiro

doi:10.2147/ceg.s252913

Cited by 3 publications

(2 citation statements)

References 38 publications

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“…The rate of median increase in plasma acylated ghrelin levels between days 3 and 8 tended to be higher in the rikkunshito than in the control course (68 vs. 48%, P = 0.08). For delayed gastric emptying after pancreaticoduodenectomy, the 21-day administration of rikkunshito showed a significantly upregulating in total ghrelin and acylated ghrelin levels compared to preoperative, but no obvious effect on delayed gastric emptying was observed (46). It is believed that the effectiveness of rikkunshito will become clearer in future large-scale studies.…”

Section: Clinical Studymentioning

confidence: 90%

Ghrelin Enhancer, the Latest Evidence of Rikkunshito

et al. 2021

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Rikkunshito is a Japanese herbal medicine (Kampo) that has been attracting attention and researched by many researchers not only in Japan but also worldwide. There are 214 rikkunshito articles that can be searched on PubMed by August 2021. The reason why rikkunshito has attracted so much attention is due to an epoch-making report (Gastroenterology, 2008) discovered that rikkunshito promotes the secretion of the orexigenic peptide ghrelin. Since then, many researchers have discovered that rikkunshito has a direct effect on the ghrelin receptor, GHS-R1a, and an effect of enhancing the ghrelin signal to the brain. Additionally, a lot of evidence that rikkunshito is expected to be effective for various gastrointestinal diseases have also been demonstrated. Numerous basic and clinical studies have suggested that rikkunshito affects (i) various discomforts caused by anticancer drugs, gastroesophageal reflux disease, functional dyspepsia, (ii) various stress-induced anorexia, (iii) hypophagia in the elderly, and (iv) healthy lifespan. In this review, as one who discovered the ghrelin enhancer effect of rikkunshito, we will review the research of rikkunshito so far and report on the latest research results.

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Section: Clinical Studymentioning

confidence: 90%

Ghrelin Enhancer, the Latest Evidence of Rikkunshito

et al. 2021

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“…Several studies have reported that THMs can be used to treat immune system-related diseases. [177][178][179] The anti-NETs active substances from THMs have been structurally characterized (Table 4). These active ingredients are categorized into three groups based on their reactions.…”

Section: Targeting Nets Thms Targeting Netsmentioning

confidence: 99%

Neutrophil Extracellular Traps in Tumors and Potential Use of Traditional Herbal Medicine Formulations for Its Regulation

Li,

Hu,

Naeem

et al. 2024

IJN

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Neutrophil extracellular traps (NETs) are extracellular fibers composed of deoxyribonucleic acid (DNA) and decorated proteins produced by neutrophils. Recently, NETs have been associated with the development of many diseases, including tumors. Herein, we reviewed the correlation between NETs and tumors. In addition, we detailed active compounds from traditional herbal medicine formulations that inhibit NETs, related nanodrug delivery systems, and antibodies that serve as “guiding moieties” to ensure targeted delivery to NETs. Furthermore, we discussed the strategies used by pathogenic microorganisms to evade NETs.

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A review of frequently used Kampo prescriptions. Part 5. Rikkunshito

Kainuma,

Imazu,

Imazu

et al. 2024

Traditional & Kampo Medicine

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BackgroundThe source of rikkunshito (RKT) is thought to be Yixuezhengzhuan by Yu Tuan. RKT was originally designed for many patients to treat gastrointestinal symptoms such as abdominal bloating, discomfort, nausea, and anorexia.Key FindingsRKT consists of eight types of crude drugs. Clinical studies including randomized clinical trials (RCT) for patients with non‐erosive reflux disease (NERD) refractory to proton‐pump inhibitor (PPI) have demonstrated that RKT improves not only acid‐related dysmotility symptoms, but also extra‐esophageal symptoms, and with RCT trial for functional dyspepsia (FD), RKT can simultaneously treat gastrointestinal and psychological symptoms. Moreover, RKT was recently applied to the day‐to‐day conditions, post‐operative management, and chemotherapy in cancer patients. Preclinical studies have also reported that various pharmacological functions of RKT such as its protective effect on mucosal injuries and its prokinetic effect on gastrointestinal tract motility have been elucidated. RKT was considered to increase plasma ghrelin levels by the inhibition of 5‐HT2B and 5‐HT2C receptor activities, enhanced ghrelin‐mediated signaling, inhibited degradation of acylated ghrelin to suppress decreases in plasma ghrelin levels by inhibiting the rate of degradation of acyl ghrelin to des‐acyl ghrelin, and inhibited PDE III activity. The incidence of adverse events associated with RKT was only 1.2%, and almost all adverse drug reactions were non‐serious reactions.ConclusionRKT is one of the very good candidates for beneficial medicines especially for patients presenting with intractable symptoms caused by gastrointestinal diseases such as disorders of gut–brain interaction or cancers.

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<p>Effect of Rikkunshito, a Traditional Japanese Herbal Medicine, on Delayed Gastric Emptying and Oral Dietary Intake After Pancreaticoduodenectomy: A Prospective, Randomized, Single-Center, Open-Labeled Study</p>

Cited by 3 publications

References 38 publications

Ghrelin Enhancer, the Latest Evidence of Rikkunshito

Ghrelin Enhancer, the Latest Evidence of Rikkunshito

Neutrophil Extracellular Traps in Tumors and Potential Use of Traditional Herbal Medicine Formulations for Its Regulation

A review of frequently used Kampo prescriptions. Part 5. Rikkunshito

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