&lt;p&gt;Effectiveness of Exercise Therapy on Gait Function in Diabetic Peripheral Neuropathy Patients: A Systematic Review of Randomized Controlled Trials&lt;/p&gt;

Melese, Haimanot; Alamer, Abayneh; Temesgen, Melaku Hailu; Kahsay, Gebresilassie

doi:10.2147/dmso.s261175

Cited by 29 publications

(11 citation statements)

References 43 publications

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“…In adults over the age of sixty-five, falls are the leading cause of fatal and non-fatal injuries [ 1 ], which is particularly troubling as is it predicted that by 2030, older adults will outnumber children for the first time in U.S. history [ 2 ]. Therefore, much research has endeavored to develop effective rehabilitative practices to mitigate, or even eliminate, mobility impairments in aging and neurodegenerative populations [ 3 , 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

I Can Step Clearly Now, the TENS Is On: Transcutaneous Electric Nerve Stimulation Decreases Sensorimotor Uncertainty during Stepping Movements

Whittier

Weller

Fling

2022

Sensors

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Transcutaneous electric nerve stimulation (TENS) is a method of electrical stimulation that elicits activity in sensory nerves and leads to improvements in the clinical metrics of mobility. However, the underlying perceptual mechanisms leading to this improvement are unknown. The aim of this study was to apply a Bayesian inference model to understand how TENS impacts sensorimotor uncertainty during full body stepping movements. Thirty healthy adults visited the lab on two occasions and completed a motor learning protocol in virtual reality (VR) on both visits. Participants were randomly assigned to one of three groups: TENS on first visit only (TN), TENS on second visit only (NT), or a control group where TENS was not applied on either visit (NN). Using methods of Bayesian inference, we calculated the amount of uncertainty in the participants’ center of mass (CoM) position estimates on each visit. We found that groups TN and NT decreased the amount of uncertainty in the CoM position estimates in their second visit while group NN showed no difference. The least amount of uncertainty was seen in the TN group. These results suggest that TENS reduces the amount of uncertainty in sensory information, which may be a cause for the observed benefits with TENS.

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Section: Introductionmentioning

confidence: 99%

I Can Step Clearly Now, the TENS Is On: Transcutaneous Electric Nerve Stimulation Decreases Sensorimotor Uncertainty during Stepping Movements

Whittier

Weller

Fling

2022

Sensors

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“…Diabetes affects 8.3% of Americans, and the annual treatment cost of diabetes is US$ 174 billion ( Feldman et al, 2019 ). Diabetic neuropathy is the most common chronic complication in patients with type 1 or 2 diabetes ( Javed et al, 2015 ; Melese et al, 2020 ) and accounts for 54–59% and 45% of type 1 and type 2 diabetic patients ( Zilliox and Russell, 2011 ), respectively. Pain, abnormal sensation, and decreased stability are the typical clinical symptoms of diabetic neuropathy ( Goldberg et al, 2008 ; Marcovecchio et al, 2010 ).…”

Section: Introductionmentioning

confidence: 99%

Mechanisms of exercise for diabetic neuropathic pain

Zhu

Gou

2022

Front. Aging Neurosci.

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Diabetic neuropathic pain (DNP) is a common disease that affects the daily lives of diabetic patients, and its incidence rate is very high worldwide. At present, drug and exercise therapies are common treatments for DNP. Drug therapy has various side effects. In recent years, exercise therapy has received frequent research and increasing attention by many researchers. Currently, the treatment of DNP is generally symptomatic. We can better select the appropriate exercise prescription for DNP only by clarifying the exercise mechanism for its therapy. The unique pathological mechanism of DNP is still unclear and may be related to the pathological mechanism of diabetic neuropathy. In this study, the mechanisms of exercise therapy for DNP were reviewed to understand better the role of exercise therapy in treating DNP.

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Section: Introductionmentioning

confidence: 99%

“…When vitamin B 12 deficiency is prolonged, it leads to nerve degeneration, causing irreversible nerve damage. 5 Previous researchers have explored the benefits of vitamin B 12 and have discovered that it stimulates nerve regeneration by promoting axon growth of neural cells after peripheral nerve damage. 6 On the other hand, the naturally occurring ALA, an organosulfur compound derived from octanoic acid, 7 is required to generate energy in the mitochondria by various enzymes.…”

Section: Introductionmentioning

confidence: 99%

Exploring the effectiveness of vitamin B₁₂ complex and alpha-lipoic acid as a treatment for diabetes mellitus/neuropathy: a protocol for systematic review and meta-analysis of randomised controlled trials

Lekhanya

Mokgalaboni

2022

BMJ Open

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IntroductionDiabetic neuropathy (DN) is common in patients diagnosed with diabetes mellitus. This often causes peripheral nerve damage. For many years vitamin B12 and alpha-lipoic acid (ALA) have been regarded as components that can be used in reducing markers of inflammation and oxidative stress. In this study, we will explore the effectiveness of vitamin B12 and ALA as a possible treatment for diabetic mellitus/neuropathy, emphasising markers of inflammation, lipid profile, and glucose metabolism.Methods and analysisWe will conduct a systematic review following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Protocol (PRISMA-P). The search strategies and information sources for the literature will be PubMed, Google Scholar, Web of Science and Science direct. The literature search will include studies published from inception until 30 June 2022. All included studies will be evaluated for quality and risk of bias according to the Cochrane guidelines. To investigate the stability of the results, we will conduct a sensitivity analysis of the outcomes. All data analysis will be performed using Review Manager V.5. 4.Ethical and disseminationThis systematic review and meta-analysis will not require ethical approval from an institution committee as it does not have direct participants. We will obtain all our data from previous studies. The findings will be disseminated through publications in peer-reviewed journals and presented at local and international seminars and conferences.

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<p>Effectiveness of Exercise Therapy on Gait Function in Diabetic Peripheral Neuropathy Patients: A Systematic Review of Randomized Controlled Trials</p>

Cited by 29 publications

References 43 publications

I Can Step Clearly Now, the TENS Is On: Transcutaneous Electric Nerve Stimulation Decreases Sensorimotor Uncertainty during Stepping Movements

I Can Step Clearly Now, the TENS Is On: Transcutaneous Electric Nerve Stimulation Decreases Sensorimotor Uncertainty during Stepping Movements

Mechanisms of exercise for diabetic neuropathic pain

Exploring the effectiveness of vitamin B₁₂ complex and alpha-lipoic acid as a treatment for diabetes mellitus/neuropathy: a protocol for systematic review and meta-analysis of randomised controlled trials

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<p>Effectiveness of Exercise Therapy on Gait Function in Diabetic Peripheral Neuropathy Patients: A Systematic Review of Randomized Controlled Trials</p>

Cited by 29 publications

References 43 publications

I Can Step Clearly Now, the TENS Is On: Transcutaneous Electric Nerve Stimulation Decreases Sensorimotor Uncertainty during Stepping Movements

I Can Step Clearly Now, the TENS Is On: Transcutaneous Electric Nerve Stimulation Decreases Sensorimotor Uncertainty during Stepping Movements

Mechanisms of exercise for diabetic neuropathic pain

Exploring the effectiveness of vitamin B12 complex and alpha-lipoic acid as a treatment for diabetes mellitus/neuropathy: a protocol for systematic review and meta-analysis of randomised controlled trials

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Exploring the effectiveness of vitamin B₁₂ complex and alpha-lipoic acid as a treatment for diabetes mellitus/neuropathy: a protocol for systematic review and meta-analysis of randomised controlled trials