<p>Effects of Anesthesia on Postoperative Recurrence and Metastasis of Malignant Tumors</p>

Abstract

It is difficult to control the recurrence and metastasis of malignant tumors; furthermore, anesthesia is considered one of the main influencing factors. There has been increasing clinical attention on the effects of anesthetic drugs and methods on postoperative tumor growth and metastasis. We reviewed the effects of anesthesia on tumor recurrence and metastasis; specifically, the effects of anesthetic agents, anesthesia methods, and related factors during the perioperative period on the tumor growth and metastasis were analyzed. This study can provide reference standards for rational anesthesia formulations and cancerrelated pain analgesia protocols for surgical procedures in patients with malignant tumors. Moreover, it contributes toward an experimental basis for the improvement and development of novel anesthetic agents and methods.

Effect of Ultrasound-Guided Quadratus Lumborum Block Preemptive Analgesia on Postoperative Recovery of Patients with Open Radical Colon Cancer Surgery: A Retrospective Study

“…[1][2][3] Postoperative pain can delay the wound healing, the first ambulation and the recovery of intestinal tract, leading to the patient's body in a stress status, which results in the damage of immune function, thus promoting the recurrence and metastasis of tumor after surgery, and delaying the overall postoperative recovery speed. [4][5][6][7][8][9][10][11][12] It has been demonstrated that scientific and reasonable pain management is helpful to reduce complications and accelerate the recovery of patients. 13 For a long time, opioids have played a major role in postoperative analgesia, but heavy use of these drugs will cause adverse reactions such as nausea, vomiting and enteroparalysis, which is not conducive to rapid recovery after surgery.…”

Procaine–The Controversial Geroprotector Candidate: New Insights Regarding Its Molecular and Cellular Effects

“…Reexpression of methylation silenced tumor suppressor genes by inhibiting the DNMTs (DNMT1, DNMT3A, and DNMT3B) has emerged as an effective strategy against cancer [ 126 ]. A large number of preclinical studies have shown that local anesthetics have a direct inhibitory effect on tumor activities, including cell survival, proliferation, migration, and invasiveness [ 41 , 127 , 128 ]. Recently, Moreira-Silva et al (2020) cited procaine among the “repurposed drugs” which have demonstrated promising results as epigenetic inhibitor in in vitro tumorigenesis [ 129 ].…”

Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation

“…Local anesthetics are widely used in clinical cancer surgery [1,2]. Current data indicate that anesthetics or anesthesia techniques may affect cancer metastasis and postoperative recurrence [3,4]. When local anesthetics are absorbed into the circulation or administered intravenously, they have a direct effect on cancer cells [3].…”