&lt;p&gt;Epidemiology of Human Adenoviruses: A 20-Year Retrospective Observational Study in Hospitalized Patients in Bern, Switzerland&lt;/p&gt;

Akello, Joyce Odeke; Kamgang, Richard; Barbani, Maria Teresa; Suter‐Riniker, Franziska; Leib, Stephen L.; Ramette, Alban

doi:10.2147/clep.s246352

Cited by 38 publications

(50 citation statements)

References 52 publications

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“…The present study recorded the epidemiological distribution of circulating HAdV strains among hospitalized patients with respiratory tract infections (RTIs) between 2017 and 2019 in Guangzhou City, China. In this study, the overall positive rate of HAdV was 2.4%, which is consistent with the positive rate (2.0%-6.1%) found in hospitalized patients with acute viral respiratory infection in other recent reports [3,[19][20][21]. However, two previous studies conducted in the Northern part of China showed a higher HAdV prevalence (10.4%-20.1%) than our study [22,23].…”

Section: Discussionsupporting

confidence: 92%

“…But it was not consistent with that of studies conducted in Northern China [22] and Mexico [29]. In Tanzania and Switzerland, HAdV infections were observed during all seasons of the year with no clear seasonality demonstrated [21,27]. These difference in HAdV prevalence between seasons are interesting and bear future study as seasonal risk could in uence future employment of HAdV vaccines which are in development in China [30].…”

Section: Discussioncontrasting

confidence: 56%

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Molecular Typing of Human Adenovirus Infection among Hospitalized Patients with Respiratory Tract Infections in Guangzhou, China

Wang¹,

Umar²,

Qin³

et al. 2021

Preprint

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Background Human Adenoviruses (HAdVs) cause a wide array of illnesses in all age groups. They particularly cause frequent morbidity among children. In China, human adenovirus types 3, 4, 7, 11, 14, 21, and 55 have caused at least seven outbreaks since 2000. However, limited studies are available regarding the epidemiological patterns and diversity of HAdVs types among hospitalized patients with respiratory tract infections (RTIs). Methods To understand the epidemiology and type distribution of HAdV infections associated with RTIs in China, nasal swab (NS) clinical samples were collected from 4129 patients in a Guangzhou hospital between August 2017 and October 2019. PCR, sequencing, and phylogenetic analysis were performed on these specimens to identify HAdV virus types. Results HAdV was detected in 99 (2.4%) of the 4,129 NS specimens, with the highest HAdV prevalence (6.3%) found in children between the ages of 5 and 10 years. Among HAdV-positive specimens, the most prevalent genotypes identified were HAdV-B3 (55.6%) and HAdV-B7 (25.3%). The most common symptoms in the HAdV-infected patients were fever (100%), cough (80.8%) and rhinorrhea (71.8%). HAdV infections were detected throughout the year with a relatively higher prevalence in summer. Conclusion All ages suffer adenovirus infections, but young children are at greatest risk. These study data demonstrate that at least three species of HAdVs (species B, C, and E) are circulating in Guangzhou City, China. As antiviral therapies and type-specific vaccines become available, such epidemiological data will be useful in guiding therapy and public health interventions.

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Section: Discussionsupporting

confidence: 92%

Section: Discussioncontrasting

confidence: 56%

Molecular Typing of Human Adenovirus Infection among Hospitalized Patients with Respiratory Tract Infections in Guangzhou, China

Wang¹,

Umar²,

Qin³

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…But it was not consistent with that of studies conducted in Northern China [ 21 ] and Mexico [ 26 ]. In Tanzania and Switzerland, HAdV infections were observed during all seasons of the year with no clear seasonality demonstrated [ 19 , 27 ]. These difference in HAdV prevalence between seasons are interesting and bear future study as seasonal risk could influence future employment of HAdV vaccines which are in development in China [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

Molecular typing of human adenoviruses among hospitalized patients with respiratory tract infections in a tertiary Hospital in Guangzhou, China between 2017 and 2019

et al. 2021

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Background Human Adenoviruses (HAdVs) cause a wide array of illnesses in all age groups. They particularly cause frequent morbidity among children. In China, human adenovirus types 3, 4, 7, 11, 14, 21, and 55 have caused at least seven outbreaks since 2000. However, limited studies are available regarding the epidemiological patterns and diversity of HAdVs types among hospitalized patients with respiratory tract infections (RTIs). Methods To understand the epidemiology and subtype distribution of HAdV infections associated with RTIs in China, nasal swab (NS) clinical samples were collected from 4129 patients in a Guangzhou hospital between August 2017 and October 2019. PCR, sequencing, and phylogenetic analysis were performed on these specimens to identify HAdV subtypes. Results HAdV was successfully sequenced in 99 (2.4%) of the 4129 NS specimens, with the highest HAdV prevalence (6.3%) found in children between the ages of 5 and 10 years. Among HAdV-positive specimens, the most prevalent genotypes identified were HAdV-B3 (55.6%) and HAdV-B7 (25.3%). The most common symptoms in the HAdV-infected patients were fever (100%), cough (80.8%), and rhinorrhea (71.8%). HAdV infections were detected throughout the year with a relatively higher prevalence in summer. Conclusion All ages suffer adenovirus infections, but young children are at the greatest risk. This study data demonstrates that at least three species of HAdVs (species B, C, and E) are circulating in Guangzhou City, China. As antiviral therapies and type-specific vaccines become available, such epidemiological data will be useful in guiding therapy and public health interventions.

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“…Human adenovirus (HAdV) is associated with a wide range of illnesses, ranging from common cold to more serious conditions—including serious acute respiratory infections, gastroenteritis, conjunctivitis, haemorrhagic cystitis or meningoencephalitis, which are often underreported ( 68 ). Its paramount role as an agent of RTIs is especially pertinent for children between 1 and 5 years of age ( 69 , 70 ), primarily due to their immature immune system ( 71 ).…”

Section: An Overview and Global Trendsmentioning

confidence: 99%

Seasonal Coronaviruses and Other Neglected Respiratory Viruses: A Global Perspective and a Local Snapshot

Ljubin‐Sternak

Meštrović

Lukšić

et al. 2021

Front. Public Health

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Respiratory viral infections are the leading cause of morbidity and mortality in the world; however, there are several groups of viruses that are insufficiently routinely sought for, and can thus be considered neglected from a diagnostic and clinical standpoint. Timely detection of seasonality of certain respiratory viruses (e.g., enveloped viruses such as seasonal coronaviruses) in the local context can aid substantially in targeted and cost-effective utilization of viral diagnostic approaches. For the other, non-enveloped and year-round viruses (i.e., rhinovirus, adenovirus, and bocavirus), a continuous virological diagnosis needs to be implemented in clinical laboratories to more effectively address the aetiology of respiratory infections, and assess the overall impact of these viruses on disease burden. While the coronavirus disease 2019 (COVID-19) pandemic is still actively unfolding, we aimed to emphasize the persistent role of seasonal coronaviruses, rhinoviruses, adenoviruses and bocaviruses in the aetiology of respiratory infections. Consequently, this paper concentrates on the burden and epidemiological trends of aforementioned viral groups on a global level, but also provides a snapshot of their prevalence patterns in Croatia in order to underscore the potential implications of viral seasonality. An overall global prevalence in respiratory tract infections was found to be between 0.5 and 18.4% for seasonal coronaviruses, between 13 and 59% for rhinoviruses, between 1 and 36% for human adenoviruses, and between 1 and 56.8% for human bocaviruses. A Croatian dataset on patients with respiratory tract infection and younger than 18 years of age has revealed a fairly high prevalence of rhinoviruses (33.4%), with much lower prevalence of adenoviruses (15.6%), seasonal coronaviruses (7.1%), and bocaviruses (5.3%). These insights represent a relevant discussion point in the context of the COVID-19 pandemic where the testing of non-SARS-CoV-2 viruses has been limited in many settings, making the monitoring of disease burden associated with other respiratory viruses rather difficult.

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<p>Epidemiology of Human Adenoviruses: A 20-Year Retrospective Observational Study in Hospitalized Patients in Bern, Switzerland</p>

Cited by 38 publications

References 52 publications

Molecular Typing of Human Adenovirus Infection among Hospitalized Patients with Respiratory Tract Infections in Guangzhou, China

Molecular Typing of Human Adenovirus Infection among Hospitalized Patients with Respiratory Tract Infections in Guangzhou, China

Molecular typing of human adenoviruses among hospitalized patients with respiratory tract infections in a tertiary Hospital in Guangzhou, China between 2017 and 2019

Seasonal Coronaviruses and Other Neglected Respiratory Viruses: A Global Perspective and a Local Snapshot

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