&lt;p&gt;Epigenetic Alterations of the Promoter Region of the &lt;em&gt;POMC&lt;/em&gt; Gene in Adolescent Depressive Disorder Patients with Nonsuicidal Self-injury Behaviors&lt;/p&gt;

Zheng, Doudou; Bi, Xiaojiao; Zhang, Tianliang; Han, Chao; Ma, Tantan; Wang, Lina; Sun, Mengmeng; Cui, Kaiyan; Yang, Limin; Liu, Lanfen

doi:10.2147/prbm.s272445

Cited by 18 publications

(13 citation statements)

References 37 publications

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“…Wu and co-workers reported that early-life stress reduced Pomc methylation in the serum of male mice, which was associated with an increase of Pomc mRNA [ 129 ]. Although in conflict with the results obtained in the above-mentioned clinical study in depressed adolescents [ 128 ], reduced serum Pomc methylation and increased mRNA expression persisted in mice subjected to early-life stress for up to one year [ 129 ].…”

Section: Alterations Of Dna Methylation At Specific Genes Associated ...mentioning

confidence: 82%

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DNA Methylation in Depression and Depressive-Like Phenotype: Biomarker or Target of Pharmacological Intervention?

Paoli

Misztak

Mazzini

et al. 2022

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Major depressive disorder (MDD) is a debilitating psychiatric disorder, third leading global cause of disability. As regards aetiopathogenetic mechanisms involved in the onset of depressive disorders, the interaction between genetic vulnerability traits and environmental factors is believed to play a major role. Although much is still to be elucidated about the mechanisms through which environment can interact with genetic background shaping the disease risk, there is a general agreement about a key role of epigenetic marking. In this narrative review we focused on the association between changes in DNA methylation patterns and MDD or depressive-like phenotype in animal models, as well as mechanisms of response to antidepressant drugs. W e discussed studies presenting DNA methylation changes at specific genes of interest and profiling analyses, in both patients and animal models of depression. Overall, we collected evidence showing that DNA methylation could not only be considered as a promising epigenetic biomarker of pathology but could also help in predicting antidepressant treatment efficacy. Finally, we discussed the hypothesis that specific changes in DNA methylation signature could play a role in aetiopathogenetic processes as well as in the induction of antidepressant effect.

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Section: Alterations Of Dna Methylation At Specific Genes Associated ...mentioning

confidence: 82%

“…There is only one study that investigates the correlation between MDD and methylation of POMC . POMC methylation level in blood DNA was higher in both male and female adolescent MDD patients than healthy controls [ 128 ].…”

Section: Alterations Of Dna Methylation At Specific Genes Associated ...mentioning

confidence: 99%

DNA Methylation in Depression and Depressive-Like Phenotype: Biomarker or Target of Pharmacological Intervention?

Paoli

Misztak

Mazzini

et al. 2022

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“…Nevertheless, there is evidence that at least some intraindividual DNAm signatures correlate between PBMCs and different brain regions 42 . Higher methylated POMC was observed in a group of children who were regularly abused 43 , as well as in adolescent patients with depressive disorders and non-suicidal self-injury behaviors 27 .…”

Section: Discussionmentioning

confidence: 93%

“…In rodents, early life stress led to HPA axis hyperactivity and depression-like behavior associated with persistent hypomethylation in the distal promoter region of Pomc 26 . Further, DNAm of POMC ( POMC m) was increased in depressed adolescent patients with non-suicidal self-injury behaviors compared to healthy controls 27 .…”

Section: Introductionmentioning

confidence: 98%

DNA Methylation of POMC and NR3C1-1F and Its Implication in Major Depressive Disorder and Electroconvulsive Therapy

et al. 2023

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Introduction Precision medicine in psychiatry is still in its infancy. To establish patient-tailored treatment, adequate indicators predicting treatment response are required. Electroconvulsive therapy (ECT) is considered one of the most effective options for pharmacoresistant major depressive disorder (MDD), yet remission rates were reported to be below 50%. Methods Since epigenetics of the stress response system seem to play a role in MDD, we analyzed the DNA methylation (DNAm) of genes encoding the glucocorticoid receptor (NR3C1) and proopiomelanocortin (POMC) through Sanger Sequencing. For analysis, blood was taken before and after the first and last ECT from MDD patients (n=31), unmedicated depressed controls (UDC; n=19, baseline), and healthy controls (HC; n=20, baseline). Results Baseline DNAm in NR3C1 was significantly lower in UDCs compared to both other groups (UDC: 0.014(±0.002), ECT: 0.031(±0.001), HC: 0.024(±0.002); p<0.001), whereas regarding POMC, ECT patients had the highest DNAm levels (ECT: 0.252(±0.013), UDC: 0.156(±0.015), HC: 0.162(±0.014); p<0.001). NR3C1m and POMCm decreased after the first ECT (NR3C1: p<0.001; POMC: p=0.001), and responders were less methylated compared to non-responders in NR3C1(p<0.001). Discussion Our findings indicate that both genes might play a role in the chronification of depression and NR3C1 may be relevant for ECT response prediction.

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“…Studies have shown that epigenetics, especially DNA methylation, play an important role in the occurrence, development, and progression of psychiatric disorders. In addition, research on epigenetics proves that environmental factors are also closely related to the occurrence of diseases [62,63]. Nonetheless, literature on these genes is extremely poor, and, therefore, further research is required to confirm or reject the hypothesis of their non-association with SB.…”

Section: Main Findingsmentioning

confidence: 99%

Association and Genetic Expression between Genes Involved in HPA Axis and Suicide Behavior: A Systematic Review

Hernández‐Díaz

Genis‐Mendoza

González-Castro

et al. 2021

Genes

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Background: Suicide behavior (SB) has been highly associated with the response to stress and the hypothalamic–pituitary–adrenal (HPA) axis. The aim of this study was to summarize the results obtained in genetic studies that analyzed the HPA axis—stress pathway and SB through a systematic review. Methods: We performed an online search in PubMed, EBSCO, Web of Science, Scopus, and PsycoInfo databases up to May 2021. We followed the PRISMA guidelines for systematic reviews. We included case-control and expression studies that provided data on mRNA expression and single-nucleotide polymorphisms of genes associated with SB. Results: A total of 21,926 individuals participated across 41 studies (not repeats); 34 studies provided data on single-nucleotide polymorphisms in 21,284 participants and 11 studies reported data on mRNA expression in 1034 participants. Ten genes were identified: FKBP5, CRH, CRHBP, CRHR1, CRHR2, NR3C1, NR3C2, SKA2, MC2R, and POMC. Conclusions: Our findings suggest that key stress pathway genes are significantly associated with SB and show potential as biomarkers for SB.

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<p>Epigenetic Alterations of the Promoter Region of the <em>POMC</em> Gene in Adolescent Depressive Disorder Patients with Nonsuicidal Self-injury Behaviors</p>

Cited by 18 publications

References 37 publications

DNA Methylation in Depression and Depressive-Like Phenotype: Biomarker or Target of Pharmacological Intervention?

DNA Methylation in Depression and Depressive-Like Phenotype: Biomarker or Target of Pharmacological Intervention?

DNA Methylation of POMC and NR3C1-1F and Its Implication in Major Depressive Disorder and Electroconvulsive Therapy

Association and Genetic Expression between Genes Involved in HPA Axis and Suicide Behavior: A Systematic Review

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