<p>Evaluation of Vision-Related Quality of Life after Autologous Internal Limiting–Membrane Transplantation for Refractory Macular Holes</p>

Abstract

Purpose To evaluate the vision-related quality of life of vitrectomy combined with autologous internal limiting membrane (ILM) transplantation for refractory macular holes (MHs). Methods There were 40 eyes with refractory MHs included, and all eyes received 23 G vitrectomy and ILM peeling with autologous ILM transplantation. Preoperative and postoperative basic conditions were recorded. The Chinese version of the vision-related quality-of-life scale was used to evaluate patients after operation. Quality of life, postoperative visual acuity, and size of MHs before operation were assessed with Spearman rank correlations. Results All patients were followed up for 3 months after surgery. Mean postoperative best-corrected visual acuity had significantly improved after surgery. Vision-related quality of life of patients after surgery was closely related to the MH index, but negatively correlated with best-corrected visual acuity before and after surgery. Conclusion The anatomical structure of refractory MHs with ILM peeling combined with autologous ILM transplantation was largely reduced, and the visual acuity of patients improved significantly.

Effect of internal limiting membrane surgical techniques on the idiopathic and refractory management of macular holes: a systematic review and meta-analysis

“…This treatment provides long-term good anatomical and functional results [ 52 ] 20 Yuan et al, 2020 (PMID:32801616) 40 China Mean age 55–58 RMH 85.9% Autologous ILM transplantation BCVA improved from 1.52 ± 0.29 to 1.09 ± 0.33 at 3 months. The VA of patients improved significantly improving their vision-related QoL [ 53 ] 21 Zhang et al, 2019 (PMID:31823798) 18 China Mean age 63.67 Idiopathic FTMH 82.6% ILM insertion BCVA improved at 3rd and 6th months in the NGF group, and in the insertion group after 6 months (p = 0.0081, 0.0276, and 0.0255, respectively, compared to baseline). The NGF group exhibited better recovery than the insertion group at 3rd month follow-up ( p = 0.0301).…”

A 24 month follow-up of refractory macular holes treated with an autologous transplantation of internal limiting membrane versus retina expansion technique

“…De Novelli and colleagues [ 17 ] obtained similar results in another small series of 10 eyes. Yuan et al [ 18 ] reported that quality of life measures also improved following MH closure using the AT-ILM technique.…”