<p>Familial association of lung cancer with liver cancer in first-degree relatives</p>

Abstract

Purpose: Besides the smoking and occupational exposures, heritable factors have been proven to be a risk factor for lung cancer by several population-based studies, which would misestimate the risk of lung cancer. Patients and methods: To quantify the magnitude of the high risk of lung cancer with family history, we performed a case-based study with 1373 enrolled individuals, which may be more accurate than a population-based study. Results: Risk of lung cancer was higher in people with lung cancer family history than in the control group (OR 2.50, p <0.001). Individuals with family history of liver cancer also had a higher risk of lung cancer than the control group (OR 1.78, p =0.038) while there was no significant difference within the individuals with family history of colorectal cancer, esophageal cancer, nasopharyngeal cancer or breast cancer. Furthermore, the risk of lung cancer in the subjects with early-onset cancers (age <50 years) was higher than the later-onset cancers (age ≥50 years), especially in individuals with family history of liver cancer (OR 9.24 vs 1.39). Risk of lung cancer in females with family history of lung cancer or liver cancer was higher than in males. Conclusion: The results of this study proved that the familial aggregation of lung cancer and liver cancer manifests higher risks of lung cancer, supporting the hypothesis that lung cancer and liver cancer are attributable to common familial predisposition.

<p>The Clinical Characteristics and Prognosis of Different Age Patients with Lung Cancer</p>

“…6 It has been reported that ALK rearrangement typically occurred in younger patients, which was also verified by our results. Family history of cancer is a predisposing factor for cancers, [16][17][18][19][20] including lung cancer. 21,22 According to our results, there was no difference in family cancer history among different age groups.…”

“…Family history of cancer is a predisposing factor for cancers, 16 – 20 including lung cancer. 21 , 22 According to our results, there was no difference in family cancer history among different age groups.…”

“… 23 Xu et al proved in their study that the risk of lung cancer in the subjects with early-onset cancers (<50 years) was higher than the later-onset cancers (≥50 years), especially in individuals with family history of liver cancer (OR 9.24 vs 1.39). 16 At present, most studies discuss the relationship between age and family cancer history from the perspective of family history, but few studies discuss family history from the perspective of age. The jury is still out on whether younger lung cancer is associated with more family cancer history.…”