&lt;p&gt;Focus on Notoginsenoside R1 in Metabolism and Prevention Against Human Diseases&lt;/p&gt;

Liu, Hai; Yang, Jiajun; Yang, Wanqing; Hu, Shaonan; Wu, Yang‐Chang; Zhao, Bo; Hu, Haiyan; Du, Shouying

doi:10.2147/dddt.s240511

Cited by 53 publications

(37 citation statements)

References 105 publications

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“…In the present study, sophoricoside, aucubin, notoginsenoside R1 and ginsenoside Rg1 did not exhibit cytotoxic effects. Through consulting the literature, the primary therapeutic properties of sophoricoside ( 25 , 26 ), aucubin ( 27 ) and notoginsenoside R1 ( 28 ) were found to be analgesic, anti-inflammatory, anti-viral and anti-oxidative. Up to date findings demonstrate that aucubin possesses hypolipidemic activity based on its notable anti-inflammatory and antioxidative activity, and may thus serve as a novel drug for treatment of non-alcoholic fatty liver disease (NAFLD) ( 29 ).…”

Section: Discussionmentioning

confidence: 99%

Regulation of the PTEN/PI3K/AKT pathway in RCC using the active compounds of natural products in vitro

et al. 2021

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Since Professor Tu Youyou won the 2015 Nobel Prize in Physiology and Medicine for the discovery of artemisinin, which is used to treat malaria, increased attention has been paid to the extracts obtained from plants, in order to analyze their biological activities, particularly with regard to their antitumor activity. Therefore, the present study explored the biochemical properties of seven natural plant extracts on renal cell carcinoma (RCC). 786-O and OS-RC-2 cells were cultured and treated with different concentrations of the extracts. Then, cell viability, the IC 50 value and proliferation was determined using a Cell Counting Kit-8 assay. Apoptosis and cell cycle distribution were evaluated via flow cytometry. The expression levels of proteins were assessed using western blotting, and cellular morphology was observed using a light microscope. The results showed that sophoricoside, aucubin, notoginsenoside R1 and ginsenoside Rg1 did not exhibit a cytotoxic effect on RCC cells, whereas ginsenoside Re and allicin exhibited a very slight inhibitory effect. Naringenin possessed the highest activity of the analyzed extracts. The IC 50 values of naringenin on 786-O and OS-RC-2 cells were 8.91±0.33 and 7.78±2.65 µM, respectively. In addition, naringenin notably inhibited the proliferation of RCC cells by decreasing Ki67 expression, blocked cell cycle progression in the G 2 phase by regulating expression of cell cycle proteins, and increased apoptosis by upregulating caspase-8 expression, downregulating Bcl-2 expression and altering the cellular morphology. Furthermore, naringenin inhibited cell proliferation and promoted apoptosis by upregulating the expression of PTEN at the protein level, downregulated the expression of PI3K and phosphorylated-(p-)AKT, but did not affect the expression of AKT, mTOR or p-mTOR. The seven plant extracts analyzed showed differing degrees of anti-RCC activity. Sophoricoside, aucubin, notoginsenoside R1 and ginsenoside Rg1 did not exhibit notable anti-RCC activity, whereas the effect of ginsenoside Re and allicin on RCC was considerably weak. However, naringenin showed potent anti-proliferative, apoptosis inducing and cell cycle arresting activity on RCC cells via regulation of the PTEN/PI3K/AKT signaling pathway.

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Section: Discussionmentioning

confidence: 99%

Regulation of the PTEN/PI3K/AKT pathway in RCC using the active compounds of natural products in vitro

et al. 2021

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“…ESR and AR are steroid hormone receptor. ESR signaling has shown its importance in ischemiainduced angiogenesis 46,47 and neural injury gradually [48][49][50] . But the effects of sex hormones in DR are not fully understood and quite controversial at present.…”

Section: Discussionmentioning

confidence: 99%

A Network Pharmacology Based Analysis of The Potential Mechanisms of Compound Danshen Dripping Pill for Treatment of Diabetic Retinopathy

Zhang¹,

Wang²,

Huang³

et al. 2020

Preprint

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Background: Diabetic retinopathy (DR) has become a worldwide concern in recent years because of the high prevalence and vision-threat. The limited therapies have been in stark contrast to its high prevalence. On top of that, almost all the treatments, like laser, are applied only at the end stage of this disease. However, with the development of network pharmacology, a traditional Chinese medicine (TCM), Compound Danshen Dripping Pill (CDDP), may bring some new insights into the early intervention of DR. Methods: The active compounds and potential targets of CDDP and DR-related targets were collected from the TCMSP, UniProt, GeneCards and OMIM databases. And protein-protein interactions (PPI) information was achieved from the STRING database. The gene enrichment analysis of GO and KEGG was carried out by “clusterProfiler” in R software. The collected data was then used to form network maps of compound-target and PPI, or visualized by the software of Cytoscape. Results: 54 compounds and 50 targets were identified for CDDP against DR. Among the predicted effective compounds, 29 tanshinones from Radix Salviae (Danshen) were identified. And the core targets might be estrogen receptor (ESR1), androgen receptor (AR), caspase-3 (CASP3), Interleukin-6 (IL6) and vascular endothelial growth factor A (VEGFA) in 50 targets. There were 266 significantly correlated biological processes such as steroid hormone response, oxidative stress and apoptosis enriched out. Besides, The 50 targets significantly participate in 97 pathways and mainly enriched in advanced glycation end products (AGE)-receptor for advanced glycation end products (RAGE), fluid shear stress and atherosclerosis, apoptosis and VEGF signal pathway et al.Conclusions: The mechanisms of CDDP for treating DR may involve multi-compound, multi-target and multi-pathway synergistic effects. It may participate in the regulation of steroid hormone response, oxidative stress, apoptosis and hemodynamics in diabetic retina. Tanshinones and luteolin from Radix Salviae were probably responsible for the effectiveness of CDDP on DR.

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“…Saponins are the main active ingredients of Panax notoginseng, among which ginsenosides Rg1, Rb1, and notoginsenoside R1 are the main active monomers (15). These active ingredients have broad bioactivity, including in the cerebral and cardiovascular system (16), liver (17), kidney (18), and bone; and showed significant pharmacological intervention activities in other system diseases (19). In recent years, the academic community has paid increasing attention to its immunomodulatory activity (8,20), and relevant studies have demonstrated that it has a significant therapeutic effect on acute lung injury (21).…”

Section: Notoginsenoside R1 Reduced Il-1β Levels In Lps-induced Ali Ratsmentioning

confidence: 99%

Protective effects of notoginsenoside R1 on acute lung injury in rats with sepsis

Cao

Xu²,

Liu³

et al. 2021

Ann Transl Med

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Background: To clarify the mechanism of notoginsenoside R1 in the treatment of septic acute lung injury (ALI) based on network pharmacological analysis, and to verify it in the model of septic ALI in rats.Methods: Based on database searching, the related targets of notoginsenoside R1 and ALI were identified, and the component-disease-target network was constructed. The core targets were screened by proteinprotein interaction (PPI), and the functional enrichment of Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) was analyzed. The rat model of septic ALI was further established to investigate the pharmacological effects of notoginsenoside R1.Results: Notoginsenoside R1 possibly affected ALI through 150 targets, of which 36 were core targets.GO semantic similarity analysis showed that notoginsenoside R1 might play a role in regulating interleukin 17 (IL-17) signal pathway, tumor necrosis factor (TNF) signal pathway and other key links by regulating MAPK1, MAPK3, IL-1β and other targets. The results of pharmacological experiments showed that notoginsenoside R1 could significantly reduce the wet:dry ratio of the lung in an animal model of ALI, improve the pathological injury of the lung, and reduce the content of IL-1β in serum and in bronchoalveolar lavage fluid (BALF) of experimental animals.Conclusions: Notoginsenoside R1 can inhibit pulmonary edema, reduce inflammation, and improve lung lesions through multiple targets and pathways to achieve the pharmacological effects in the treatment of septic ALI.

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<p>Focus on Notoginsenoside R1 in Metabolism and Prevention Against Human Diseases</p>

Cited by 53 publications

References 105 publications

Regulation of the PTEN/PI3K/AKT pathway in RCC using the active compounds of natural products in vitro

Regulation of the PTEN/PI3K/AKT pathway in RCC using the active compounds of natural products in vitro

A Network Pharmacology Based Analysis of The Potential Mechanisms of Compound Danshen Dripping Pill for Treatment of Diabetic Retinopathy

Protective effects of notoginsenoside R1 on acute lung injury in rats with sepsis

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