&lt;p&gt;Forkhead Box S1 Inhibits the Progression of Hepatocellular Carcinoma&lt;/p&gt;

Lei, Dengliang; Hu, Gangli; Chen, Yue; Hao, Tuantuan; Gao, Yu

doi:10.2147/ott.s272596

Cited by 9 publications

(9 citation statements)

References 27 publications

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“…Regardless of previously conflicting reports in gastric cancer and HCC, ( 38 ) our data highlight a role of FOXS1 in EMT in HCC, as evidenced by changes in the expression of EMT markers (e.g., VIM and CDH1) and effectors (e.g., SNAI1 and SNAI2) as well as the impact of FOXS1 on cell migration. Those results are in agreement with the reported role of FOXS1 during embryonic development, in which FOXS1 is expressed in migrating neural crest cells.…”

Section: Discussioncontrasting

confidence: 54%

TGFβ‐induced FOXS1 controls epithelial–mesenchymal transition and predicts a poor prognosis in liver cancer

et al. 2021

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Transforming growth factor beta (TGF‐β) plays a key role in tumor progression, notably as a potent inducer of epithelial–mesenchymal transition (EMT). However, all of the molecular effectors driving TGFβ‐induced EMT are not fully characterized. Here, we report that forkhead box S1 (FOXS1) is a SMAD (mothers against decapentaplegic)–dependent TGFβ‐induced transcription factor, which regulates the expression of genes required for the initial steps of EMT (e.g., snail family transcription repressor 1) and to maintain a mesenchymal phenotype in hepatocellular carcinoma (HCC) cells. In human HCC, we report that FOXS1 is a biomarker of poorly differentiated and aggressive tumor subtypes. Importantly, FOXS1 expression level and activity are associated with a poor prognosis (e.g., reduced patient survival), not only in HCC but also in colon, stomach, and kidney cancers. Conclusion: FOXS1 constitutes a clinically relevant biomarker for tumors in which the pro‐metastatic arm of TGF‐β is active (i.e., patients who may benefit from targeted therapies using inhibitors of the TGF‐β pathway).

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Section: Discussioncontrasting

confidence: 54%

TGFβ‐induced FOXS1 controls epithelial–mesenchymal transition and predicts a poor prognosis in liver cancer

et al. 2021

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“…The role of FOXS1 in the development and progression of human cancers is largely unknown. There are only a few studies that have reported that FOXS1 was involved in the regulation of cancer cell biology in gastric cancer ( 24 , 25 ), hepatocellular carcinoma ( 26 , 27 ), and glioma cells ( 28 ). Nevertheless, the role of FOXS1 in cancer remains controversial according to the results from these studies.…”

Section: Discussionmentioning

confidence: 99%

“…On the contrary, Lei et al. reported that FOXS1 is downregulated hepatocellular carcinoma and overexpression of FOXS1 inhibited the proliferation and migration of hepatocellular carcinoma cells ( 27 ). These studies demonstrated conflicting results, probably due to using different cell lines.…”

Section: Discussionmentioning

confidence: 99%

“…showed that FOXS1 evidently promoted EMT in PLC/PRF/5 ( 26 ), while Lei et al. demonstrated that FOXS1 suppressed EMT in Huh7 and Hep3B cell lines ( 27 ). These opposite results suggest that the function of FOXS1 could be dependent on specific cell-specific contexts associated with different genetic/epigenetic backgrounds of cancer subtypes.…”

Section: Discussionmentioning

confidence: 99%

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FOXS1 Promotes Tumor Progression by Upregulating CXCL8 in Colorectal Cancer

Qiu

et al. 2022

Front. Oncol.

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BackgroundForkhead box S1 (FOXS1) is a member of the forkhead box (FOX) transcriptional factor superfamily. The biological roles and underlying regulatory mechanism of FOXS1 in CRC remain unclear.MethodsBioinformatics analysis, Western blotting, real-time PCR, and immunohistochemistry (IHC) were used to detect the expression FOXS1 in CRC. MTT assay, transwell assay, human umbilical vein endothelial cell tube formation assay, and chicken chorioallantoic membrane assay were performed to investigate the effects of FOXS1 on proliferation, invasion, and angiogenesis. Additionally, tumor formation assay and orthotopic implantation assay were used to investigate the effects of FOXS1 on tumor growth and metastasis in vivo. Furthermore, gene set enrichment analysis (GSEA) was used to analyze the correlation between FOXS1 and EMT or angiogenesis. The correlation between FOXS1 and CXCL8 expression was analyzed in clinical CRC samples using IHC.ResultsThe results showed that FOXS1 expression was upregulated in CRC tissues compared with adjacent normal intestine tissues. A high FOXS1 expression is positively correlated with poor survival. FOXS1 promoted the malignant behavior of CRC cancer cells in vitro, including proliferation, invasion, and angiogenesis. In addition, FOXS1 promoted tumor growth and metastasis in nude mice. Mechanistically, FOXS1 upregulated the expression of C–X–C motif chemokine ligand 8 (CXCL8) at the transcriptional level. Knockdown of CXCL8 blocked FOXS1 induced the enhancement of the EMT and angiogenesis. GSEAs in public CRC datasets revealed strong correlations between FOXS1 expression and EMT marker and angiogenesis markers. IHC showed that FOXS1 expression was positively correlated with CXCL8 expression and CD31 expression in clinical CRC samples.ConclusionThe results suggest that FOXS1 promotes angiogenesis and metastasis by upregulating CXCL8 in CRC. Interference with the FOXS1/CXCL8 axis may serve as a potential therapeutic target for the treatment of metastatic CRC.

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“…With lower RIF1 scores for the ALA, TF such as the FOXS1 and UBP1 —“gene expression” (GO:0010467) and GZF1 —“DNA binding” (GO:0003677) were identified. The FT FOXS1 is associated with several cell proliferation steps [ 71 ], and its overexpression inhibited tumor cell proliferation. The FT GZF1 is also involved in the cell proliferation process; however, it was related to cell proliferation promotion in cell culture [ 72 ].…”

Section: Discussionmentioning

confidence: 99%

Transcriptome Profile Reveals Genetic and Metabolic Mechanisms Related to Essential Fatty Acid Content of Intramuscular Longissimus thoracis in Nellore Cattle

et al. 2022

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Beef is a source of essential fatty acids (EFA), linoleic (LA) and alpha-linolenic (ALA) acids, which protect against inflammatory and cardiovascular diseases in humans. However, the intramuscular EFA profile in cattle is a complex and polygenic trait. Thus, this study aimed to identify potential regulatory genes of the essential fatty acid profile in Longissimus thoracis of Nellore cattle finished in feedlot. Forty-four young bulls clustered in four groups of fifteen animals with extreme values for each FA were evaluated through differentially expressed genes (DEG) analysis and two co-expression methodologies (WGCNA and PCIT). We highlight the ECHS1, IVD, ASB5, and ERLIN1 genes and the TF NFIA, indicated in both FA. Moreover, we associate the NFYA, NFYB, PPARG, FASN, and FADS2 genes with LA, and the RORA and ELOVL5 genes with ALA. Furthermore, the functional enrichment analysis points out several terms related to FA metabolism. These findings contribute to our understanding of the genetic mechanisms underlying the beef EFA profile in Nellore cattle finished in feedlot.

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<p>Forkhead Box S1 Inhibits the Progression of Hepatocellular Carcinoma</p>

Cited by 9 publications

References 27 publications

TGFβ‐induced FOXS1 controls epithelial–mesenchymal transition and predicts a poor prognosis in liver cancer

TGFβ‐induced FOXS1 controls epithelial–mesenchymal transition and predicts a poor prognosis in liver cancer

FOXS1 Promotes Tumor Progression by Upregulating CXCL8 in Colorectal Cancer

Transcriptome Profile Reveals Genetic and Metabolic Mechanisms Related to Essential Fatty Acid Content of Intramuscular Longissimus thoracis in Nellore Cattle

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