<p>Gastrointestinal Stromal Tumors of the Small Intestine: Progress in Diagnosis and Treatment Research</p>

Abstract

In recent years, the diagnosis and treatment of gastrointestinal stromal tumors (GISTs) of the small intestine have been a hot topic due to their rarity and non-specific clinical manifestations. With the development of gene and imaging technology, surgery, and molecular targeted drugs, the diagnosis and treatment of GISTs have achieved great success. For a long time, radical resection was prioritized to treat GISTs of the small intestine. At present, preoperative tumor staging is a novel treatment for unresectable malignant tumors. In addition, karyokinesis exponent is the sole independent predictor of progression-free survival of GISTs. The DNA, miRNA, and protein of exosomes have also been found to be biomarkers with prognostic implications. The research on the treatment of GISTs has become a focus in the era of precision medicine, ushering in the use of standardized, normalized, and individualized treatment.

Pleksiform Miksoid Gastrointestinal Stromal Tümör, İnce Barsak Yerleşimli Nadir Bir Histolojik Patern: Olgu Sunumu

“…Gastrointestinal stromal tümörler tamamen asemptomatik olabileceği gibi yerleşim yeri, tümörün büyüklüğü, mukozal ülser ve nekroz varlığına bağlı olarak ağrı, gastrointestinal kanama, ele gelen kitle, kusma, anemi, ileus gibi semptomlar gösterebilirler (3). Bizim hastamız hastaneye karın ağrısı ile başvurmuştu ve yapılan radyolojik görütülemelerde kitle tespit edilerek opere edilmişti.…”

Gastrointestinal Stromal Tumor: Review

“…With the modern era where much of conventional open surgery is been replaced by the minimal invasive technique, role of minimum invasive surgery in surgical resection of GIST is indicated provided that the same oncological principal that of open surgical resection is followed. As the surgical experience increased in the laparoscopic surgical resection, small GIST of size around 2 cm were easily resected initially, according to the recent studies data tumor with size less than 5cm can be resected well through minimally invasive technique in experience hands (30).…”

A narrative review of surgical management of gastrointestinal stromal tumors

“…LR define as segmental resection of the small intestine with GISTs is usually recommended (29). For patients with a postoperative positive resection margin (R1) after the complete resection of primary localized GISTs (R0 resection), the NCCN guidelines do not recommend reoperation, whereas the ESMO guidelines recommend considering reoperation to achieve R0 resection if the original site of the lesion can be found, and no postoperative complications are expected (1,30).…”