&lt;p&gt;Genetic and Clinical Characterization of HOXB2 in Glioma&lt;/p&gt;

Pan, Xin; Liu, Wei; Chai, Yi; Wang, Junhua; Zhang, Yuqi

doi:10.2147/ott.s268635

Cited by 10 publications

(8 citation statements)

References 33 publications

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“…In glioma, homeobox B2 (HOXB2) is an independent prognostic marker. HOXB2 is related to the invasion and proliferation of glioma cells in vitro, and has a certain effect on the invasion of glioma cells (5). We examined the regulatory role of the SP1/LINC00339/miR-378a-3p/ MED19 axis in colorectal cancer, and provided new insights into the molecular mechanism of colorectal cancer (6).…”

Section: Introductionmentioning

confidence: 99%

Identification of potential biomarkers in ovarian carcinoma and an evaluation of their prognostic value

Cai¹,

Qiu²,

Wang³

et al. 2021

Ann Transl Med

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Background: Ovarian cancer is one of the most common malignant tumors in female genital organs, and its incidence rate is high. However, the pathogenesis and prognostic markers of ovarian cancer are unclear.This study sought to screen potential markers of ovarian cancer and to explore their prognostic value.Methods: The Cancer Genome Atlas, Gene Expression Omnibus, Gene Ontology and Kyoto Encyclopedia of Genes and Genomes databases were used in this study. The least absolute shrinkage and selection operator (LASSO), multivariate Cox regression and stepwise regression analysis were chosen to screen genes and construct risk model. Gene Set Enrichment Analysis (GSEA) and an immune-infiltration analysis were performed.Results: One hundred thirty two co-expressed genes were found. They involved in metabolism, protein phosphorylation, mitochondria, and immune signaling pathways. Twelve genes significantly related to the survival of ovarian cancer were identified. Eight risk genes (i.e., CACNB1, FAM120B, HOXB2, MED19, PTPN2, SMU1, WAC.AS1, and BCL2L11) were further screened and used to construct the risk model. The risk status might be an independent prognostic factor of ovarian cancer, and most of the biological functions of genes expressed in high-risk ovarian cancer were related to synapse, adhesion, and immune-related functions. The clusters of CD4+ T cells and M2 macrophages were high in high-risk status samples.Conclusions: In ovarian cancer, the abnormal expression of 8 genes, including CACNB1, FAM120B, HOXB2, MED19, PTPN2, SMU1, WAC.AS1, and BCL2L11, is closely related to ovarian cancer progression, and these genes can serve as independent prognosis markers of ovarian cancer.

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Section: Introductionmentioning

confidence: 99%

Identification of potential biomarkers in ovarian carcinoma and an evaluation of their prognostic value

Cai¹,

Qiu²,

Wang³

et al. 2021

Ann Transl Med

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“…In the esophageal squamous cell carcinoma, Sox-6 was reported as a tumor suppressor gene 47 whereas Sox-6 was shown to possess a strong oncogenic property in Ewing sarcoma 48 . In addition, other cancer-related TFs were also found in our enrichment analysis, including ALX3 (in neuroblastoma) 49 , HOXA6 (in clear renal cell carcinoma) 50 , HOXC-8, FOXO1 (in breast cancer) 51 , 52 , PARP (in neuroblastoma, endometrial cancer, breast cancer, and malignant lymphoma) 53 – 56 , IPF1 (in pancreatic neuroendocrine neoplasms) 57 , and HOXB2 (in glioma) 58 . Therefore, by focusing on germline TE insertions following identification of OS patient-specific TE insertions, we revealed the typically overlooked importance of germline TE insertions in the development of OS.…”

Section: Discussionmentioning

confidence: 60%

The insertion and dysregulation of transposable elements in osteosarcoma and their association with patient event-free survival

Wang

Liang

2022

Sci Rep

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The dysregulation of transposable elements (TEs) has been explored in a variety of cancers. However, TE activities in osteosarcoma (OS) have not been extensively studied yet. By integrative analysis of RNA-seq, whole-genome sequencing (WGS), and methylation data, we showed aberrant TE activities associated with dysregulations of TEs in OS tumors. Specifically, expression levels of LINE-1 and Alu of different evolutionary ages, as well as subfamilies of SVA and HERV-K, were significantly up-regulated in OS tumors, accompanied by enhanced DNA repair responses. We verified the characteristics of LINE-1 mediated TE insertions, including target site duplication (TSD) length (centered around 15 bp) and preferential insertions into intergenic and AT-rich regions as well as intronic regions of longer genes. By filtering polymorphic TE insertions reported in 1000 genome project (1KGP), besides 148 tumor-specific somatic TE insertions, we found most OS patient-specific TE insertions (3175 out of 3326) are germline insertions, which are associated with genes involved in neuronal processes or with transcription factors important for cancer development. In addition to 68 TE-affected cancer genes, we found recurrent germline TE insertions in 72 non-cancer genes with high frequencies among patients. We also found that +/− 500 bps flanking regions of transcription start sites (TSS) of LINE-1 (young) and Alu showed lower methylation levels in OS tumor samples than controls. Interestingly, by incorporating patient clinical data and focusing on TE activities in OS tumors, our data analysis suggested that higher TE insertions in OS tumors are associated with a longer event-free survival time.

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“…another study demonstrated that HoXB2 promoted the invasion of HoP-62 non-small cell lung cancer (nSclc) cells via transcriptionally regulating the expression of metastasis-related genes (27). in addition, HoXB2 promoted glial cell proliferation and invasion in vitro in 1,001 patients with glioma, and it was positively correlated with tumor grade and established as an independent prognostic biomarker (28). However, the effects of HoXB2 and nuSaP1 on the proliferation, invasion and migration of nephroblastoma cells remain unclear.…”

Section: Discussionmentioning

confidence: 99%

Transcription factor HOXB2 upregulates NUSAP1 to promote the proliferation, invasion and migration of nephroblastoma cells via the PI3K/Akt signaling pathway

Luo

Feng

et al. 2022

Mol Med Rep

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<p>Genetic and Clinical Characterization of HOXB2 in Glioma</p>

Cited by 10 publications

References 33 publications

Identification of potential biomarkers in ovarian carcinoma and an evaluation of their prognostic value

Identification of potential biomarkers in ovarian carcinoma and an evaluation of their prognostic value

The insertion and dysregulation of transposable elements in osteosarcoma and their association with patient event-free survival

Transcription factor HOXB2 upregulates NUSAP1 to promote the proliferation, invasion and migration of nephroblastoma cells via the PI3K/Akt signaling pathway

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