&lt;p&gt;Genetic polymorphisms in &lt;em&gt;IL-7&lt;/em&gt; and &lt;em&gt;IL-7R&lt;/em&gt; are correlated with lung cancer risk in the Chinese Han population&lt;/p&gt;

Zhang, Chan; Su, Peng; Chen, Wanlu; Li, Qi; Dai, Run; Cheng, Yujing; Yang, Jiangcun

doi:10.2147/cmar.s202839

Cited by 6 publications

(3 citation statements)

References 31 publications

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“…The genes involved in glycogen synthesis enable cancer cells to use glucose for anaerobic glycolysis to provide glycogen required during brief energy deficits [ 37 , 38 , 39 , 40 ]. IL-7 regulates tumor proliferation, apoptosis, and tumor lymphangiogenesis [ 41 , 42 , 43 , 44 , 45 ]. Therefore, we hypothesized that these four lncRNAs may play an important role in tumor immune regulation and glycogen metabolism in the tumor microenvironment of LUAD.…”

Section: Discussionmentioning

confidence: 99%

Four long noncoding RNAs act as biomarkers in lung adenocarcinoma

Zhang

Yang

et al. 2021

Open Medicine

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Introduction Lung adenocarcinoma (LUAD) is currently one of the most common malignant tumors worldwide. However, there is a lack of long noncoding RNA (lncRNA)-based effective markers for predicting the prognosis of LUAD patients. We identified four lncRNAs that can effectively predict the prognosis of LUAD patients. Methods We used data gene expression profile for 446 patients from The Cancer Genome Atlas database. The patients were randomly divided into a training set and a test set. Significant lncRNAs were identified by univariate regression. Then, multivariate regression was used to identify lncRNAs significantly associated with the survival rate. We constructed four-lncRNA risk formulas for LUAD patients and divided patients into high-risk and low-risk groups. Identified lncRNAs subsequently verified in the test set, and the clinical independence of the lncRNA model was evaluated by stratified analysis. Then mutated genes were identified in the high-risk and low-risk groups. Enrichment analysis was used to determine the relationships between lncRNAs and co-expressed genes. Finally, the accuracy of the model was verified using external database. Results A four-lncRNA signature (AC018629.1, AC122134.1, AC119424.1, and AL138789.1) has been verified in the training and test sets to be significantly associated with the overall survival of LUAD patients. Conclusions The present study demonstrated that identified four-lncRNA signature can be used as an independent prognostic biomarker for the prediction of survival of LUAD patients.

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Section: Discussionmentioning

confidence: 99%

Four long noncoding RNAs act as biomarkers in lung adenocarcinoma

Zhang

Yang

et al. 2021

Open Medicine

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“…Zhang et al [27] explored the effect of IL-7R polymorphism on lung cancer risk. The rs10053847 and rs10213865 variant was observed to be correlated with a decreased breast cancer risk under multiple genetic model, and AGAA haplotypes (rs10213865, rs969129, rs118137916, and rs10053847) also increased breast cancer risk.…”

Section: Discussionmentioning

confidence: 99%

Correlation between IL‐7R gene variants and breast cancer susceptibility in Chinese Han women

Li¹,

Yue²,

Zuo³

et al. 2020

Preprint

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Introduction IL-7R is involved in the occurrence and development of breast cancer by binding to its ligand IL-7. This study aimed to explore the potential relationships of IL-7R polymorphisms with breast cancer susceptibility in Chinese Han women.Methods Five polymorphisms (rs969129, rs10213865, rs10053847, rs118137916, and rs6451231) of IL-7R genewere genotyped in 553 patients and 550 healthy healthy individuals from the in Chinese Han women using the Agena MassARRAY platform. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated used to evaluate the relationship.Results IL-7R rs10213865, rs969129 and rs6451231 was correlated with an increased the risk of breast cancer in multiple genetic models. Age stratified analysis revealed that rs6451231 was correlated with an increased breast cancer risk at age > 52 years. Additionally, rs10213865 was correlated with tumor site and ER expression, rs969129 was related to tumor size and Ki67 expresses status, and rs6451231was related to tumor size. Haplotype CGAG (rs969129, rs10213865, rs10053847 and rs118137916) were observed to a decrease breast cancer risk.Conclusions IL-7R polymorphism were significantly correlated with an increased breast cancer susceptibility in Chinese Han women.

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“…Beyond hematological cancer, high expression of IL-7 and IL-7R in tumor tissues of breast and lung cancer patients is positively correlated with more aggressive breast cancers and poor survival [ 13 , 14 , 15 , 16 ]. Lung cancer patients carrying IL-7R rs10213865 (AGAA haplotype) have higher lung adenocarcinoma risk [ 17 ]. However, there is few data for elucidation of IL-7R level in blood cells and tumor cells from tumor patients.…”

Section: Introductionmentioning

confidence: 99%

Characterization of Circulating IL-7R Positive Cell Populations for Early Detection of Pancreatic Ductal Adenocarcinoma

Heo

Jang

Kim

et al. 2021

JCM

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(1) Background: Pancreatic cancer is a high devastating disease with the lowest survival rate among all common cancers due to difficulties in early diagnosis. The purpose of this study was to identify and characterize the distinct subset of blood cell population elevated in peripheral blood mononuclear cells (PBMC) of pancreatic cancer to evaluate the potential markers for diagnosis of pancreatic cancer; (2) Methods: We analyzed differential gene expression in PBMC from normal individuals and pancreatic cancer patients utilizing transcriptome analysis. Flow cytometry analysis was applied to identify the discrete subset of interleukin-7 receptor (IL-7R) expressing cells in these cells. The expression of IL-7R during tumorigenesis was determined in syngeneic mouse model of pancreatic cancer in vivo; (3) Results: PBMC from pancreatic cancer patients expressed elevated IL-7R mRNA compared to healthy control individuals. IL-7R expressing cells rapidly appeared from the early stages of the onset of tumor formation in syngeneic pancreatic cancer mouse model in vivo. The discrete subset of IL-7R positive cells mainly consist of naïve T, central memory T, and effector memory T cells; (4) Conclusions: Taken together, our present findings suggest that pancreatic cancer patients expressed higher level of IL-7R expression in PBMC that rapidly emerged from the onset of early pancreatic tumor formation in vivo than normal individuals. Thus, it can be used as a novel biological marker for early events of pancreatic cancer development.

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<p>Genetic polymorphisms in <em>IL-7</em> and <em>IL-7R</em> are correlated with lung cancer risk in the Chinese Han population</p>

Cited by 6 publications

References 31 publications

Four long noncoding RNAs act as biomarkers in lung adenocarcinoma

Four long noncoding RNAs act as biomarkers in lung adenocarcinoma

Correlation between IL‐7R gene variants and breast cancer susceptibility in Chinese Han women

Characterization of Circulating IL-7R Positive Cell Populations for Early Detection of Pancreatic Ductal Adenocarcinoma

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