<p>Genistein diet improves body weight, serum glucose and triglyceride levels in both male and female ob/ob mice</p>

Abstract

PurposeDiabetic obesity in the leptin-deficient ob/ob mouse is associated with weight gain, and hyperglycemia, along with hyperinsulinemia. We have previously examined the effects of genistein (a naturally occurring isoflavone found in soy) on metabolic disturbances in the ob/ob mouse and demonstrated beneficial effects of genistein (600 mg genistein/kg diet, for 4-weeks) on T3 production and corticosterone status. The goal of this study was to examine whether dietary genistein could prevent, or at least lessen, the typical phenotype in this murine model of diabetic-obesity, and to assess potential sex-differences.Patients and methodsThe ob/ob mice (male and female) aged 4–5 weeks were randomly assigned to one of two diets for a period of 4-weeks: standard rodent diet, or genistein-containing diet (600 mg genistein/kg diet). Comparisons were made to a lean control group.ResultsGenistein diet significantly reduced body weight by 12% in females and 9% in males. Genistein significantly lowered serum glucose levels by 18% in females and 43% in males, yet had no effect on serum insulin. Genistein diet significantly lowered serum triglyceride levels in both ob/ob male and female mice returning them to lean levels. In females only, genistein significantly reduced serum pancreatic polypeptide levels by 56% and increased serum GIP levels 2.3-fold. Genistein had sex-dependent effects on hepatic steatosis: in females, genistein further increased the % fat area and the fat droplet diameter 2.6-fold, along with additionally increasing hepatic TBARS.ConclusionThe results from this study indicate interesting beneficial effects of genistein diet for both male and female ob/ob mice.

Dietary polyphenols as antidiabetic agents: Advances and opportunities

“…Moreover, puerarin ameliorates diabetic complications, such as cardiovascular complications, diabetic nephropathy, retinopathy, neuropathy, and so on. Genistein benefits type 2 diabetes via remarkably ameliorating hyperglycemia (Fu et al., 2012; Rockwood et al., 2019), enhancing β‐cell proliferation and reducing apoptosis (Gilbert & Liu, 2013), ameliorating cardiac inflammation and oxidative stress (Gupta et al., 2015), improving fracture resistance (Odle, Dennison, Al‐Nakkash, Broderick, & Plochocki, 2017), ameliorating vascular dysfunction (Valsecchi et al., 2011), and alleviating diabetic neuropathy, nephropathy, and retinopathy (Weng, Zhang, Wang, Ma, & Song, 2019).…”

Estrogen-Related Receptor Alpha: An Under-Appreciated Potential Target for the Treatment of Metabolic Diseases

“…This leads to the upregulation of metabolic genes that promote mitochondrial biogenesis and activity [84]. Furthermore, genistein, a plant-derived compound, has recently been found to be an ESRRA agonist by small molecule screening [55,56,85], and improves diet-induced obesity by increasing energy expenditure, lipid catabolism via AMPK activation, and the serum TH concentration [86][87][88][89]. TH activates the PPARGC1A-ESRRA axis to increase mitochondrial biogenesis, activity, and turnover [62].…”

Metabolic Impact of Flavonoids Consumption in Obesity: From Central to Peripheral

“…In animal studies, isoflavones have showed antidiabetic and anti-obesity activities [ 45 , 236 , 297 , 300 ]. The beneficial effects of isoflavones include the improvement of insulin sensitivity, lipid profile and adiposity [ 45 , 49 , 301 , 302 , 303 ].…”