&lt;p&gt;Gigantol Attenuates the Metastasis of Human Bladder Cancer Cells, Possibly Through Wnt/EMT Signaling&lt;/p&gt;

Zhao, Miaomiao; Sun, Yangyang; Cui, Hongqiu; Chen, Jianbin; Wang, Meina; Wang, Zhicai

doi:10.2147/ott.s271032

Cited by 18 publications

(18 citation statements)

References 37 publications

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“…The typical parent nucleus structure of bibenzyls presented in the stems of D. officinale is two benzene rings, which can be replaced by different substituents. Some bibenzyls (4, 5, and 7) were found to have significant anti-tumor activity (Tian et al, 2019;Zhao et al, 2020), which attracted further research and development. The chemical structures of these bibenzyls are shown in Figure 2.…”

Section: Bibenzylsmentioning

confidence: 99%

“…Besides, it is usually prescribed as one of the ingredients of herbal formula, such as "Tin maple crystal" (Tiepifengdoujing: D. officinale and American ginseng), for regulating the gastrointestinal tract in traditional and contemporary clinical practice (Qin et al, 2019). According to currently available phytochemical investigations, the bioactive chemical components of D. officinale mainly consist of polysaccharides (Zhao et al, 2019), bibenzyls (Zhao et al, 2020), phenanthrenes (Liu et al, 2019), flavonoids (Xing et al, 2018), and alkaloids (Chu et al, 2019). In contrast, according to the literature, only few of these compounds have been evaluated in bioactivity assays (Zhao et al, 2018a;Liu et al, 2018;Xing et al, 2018;Chu et al, 2019;Liu et al, 2019;Lee et al, 2020;Zhao et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

“…According to currently available phytochemical investigations, the bioactive chemical components of D. officinale mainly consist of polysaccharides (Zhao et al, 2019), bibenzyls (Zhao et al, 2020), phenanthrenes (Liu et al, 2019), flavonoids (Xing et al, 2018), and alkaloids (Chu et al, 2019). In contrast, according to the literature, only few of these compounds have been evaluated in bioactivity assays (Zhao et al, 2018a;Liu et al, 2018;Xing et al, 2018;Chu et al, 2019;Liu et al, 2019;Lee et al, 2020;Zhao et al, 2020). Additionally, although D. officinale is utilized as an effective matter to treat various diseases, its quality control and safety have yet to be defined.…”

Section: Introductionmentioning

confidence: 99%

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Traditional Uses, Phytochemistry, Pharmacology, and Quality Control of Dendrobium officinale Kimura et. Migo

Wen-hua

Zhang

et al. 2021

Front. Pharmacol.

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Dendrobium officinale, a well-known plant used as a medicinal and food homologous product, has been reported to contain various bioactive components, such as polysaccharides, bibenzyls, phenanthrenes, and flavonoids. It is also widely used as a traditional medicine to strengthen “Yin”, nourish heart, tonify five viscera, remove arthralgia, relieve fatigue, thicken stomach, lighten body, and prolong life span. These traditional applications are in consistent with modern pharmacological studies, which have demonstrated that D. officinale exhibits various biological functions, such as cardioprotective, anti-tumor, gastrointestinal protective, anti-diabetes, immunomodulatory, anti-aging, and anti-osteoporosis effects. In this review, we summarize the research progress of D. officinale from November 2016 to May 2021 and aim to better understand the botany, traditional use, phytochemistry, and pharmacology of D. officinale, as well as its quality control and safety. This work presents the development status of D. officinale, analyzes gaps in the current research on D. officinale, and raises the corresponding solutions to provide references and potential directions for further studies of D. officinale.

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Section: Bibenzylsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Traditional Uses, Phytochemistry, Pharmacology, and Quality Control of Dendrobium officinale Kimura et. Migo

Wen-hua

Zhang

et al. 2021

Front. Pharmacol.

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“…Among the bladder cancer patients, approximately 25% of patients have muscle invasive disease caused by metastasis that essentially is responsible for aggressiveness, high grade disease, and mortality [6,71]. Accumulated evidences have established that epithelial-mesenchymal transition (EMT) progression is a key event in metastasis and invasion of tumor including bladder cancer [72][73][74]. EMT can be triggered by the various signaling pathways, and result in activation of the transcriptional factors including Snail, Slug, Zeb1, and Twist1, and subsequently lead to migration and invasion by up-regulation of MMP-2 and -9 [72,75,76].…”

Section: Discussionmentioning

confidence: 99%

“…EMT can be triggered by the various signaling pathways, and result in activation of the transcriptional factors including Snail, Slug, Zeb1, and Twist1, and subsequently lead to migration and invasion by up-regulation of MMP-2 and -9 [72,75,76]. One study reported that gigantol, a bibenzyl compound, inhibited the metastasis in bladder cancer cells through Wnt/βcatenin signaling [73], and another study showed that MiR-22 suppressed EMT progression through Snail and mitogen-activated protein kinase 1/Slug/vimentin [74]. In the present study, we found that BA suppressed migration and invasion in all three bladder cancer cells, as well as down-regulated the expression of the metastatic-related proteins including Snail, Slug, and MMP-9.…”

Section: Discussionmentioning

confidence: 99%

Betulinic Acid Restricts Human Bladder Cancer Cell Proliferation In Vitro by Inducing Caspase-Dependent Cell Death and Cell Cycle Arrest, and Decreasing Metastatic Potential

et al. 2021

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Betulinic acid (BA) is a naturally occurring pentacyclic triterpenoid and generally found in the bark of birch trees (Betula sp.). Although several studies have been reported that BA has diverse biological activities, including anti-tumor effects, the underlying anti-cancer mechanism in bladder cancer cells is still lacking. Therefore, this study aims to investigate the anti-proliferative effect of BA in human bladder cancer cell lines T-24, UMUC-3, and 5637, and identify the underlying mechanism. Our results showed that BA induced cell death in bladder cancer cells and that are accompanied by apoptosis, necrosis, and cell cycle arrest. Furthermore, BA decreased the expression of cell cycle regulators, such as cyclin B1, cyclin A, cyclin-dependent kinase (Cdk) 2, cell division cycle (Cdc) 2, and Cdc25c. In addition, BA-induced apoptosis was associated with mitochondrial dysfunction that is caused by loss of mitochondrial membrane potential, which led to the activation of mitochondrial-mediated intrinsic pathway. BA up-regulated the expression of Bcl-2-accociated X protein (Bax) and cleaved poly-ADP ribose polymerase (PARP), and subsequently activated caspase-3, -8, and -9. However, pre-treatment of pan-caspase inhibitor markedly suppressed BA-induced apoptosis. Meanwhile, BA did not affect the levels of intracellular reactive oxygen species (ROS), indicating BA-mediated apoptosis was ROS-independent. Furthermore, we found that BA suppressed the wound healing and invasion ability, and decreased the expression of Snail and Slug in T24 and 5637 cells, and matrix metalloproteinase (MMP)-9 in UMUC-3 cells. Taken together, this is the first study showing that BA suppresses the proliferation of human bladder cancer cells, which is due to induction of apoptosis, necrosis, and cell cycle arrest, and decrease of migration and invasion. Furthermore, BA-induced apoptosis is regulated by caspase-dependent and ROS-independent pathways, and these results provide the underlying anti-proliferative molecular mechanism of BA in human bladder cancer cells.

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Serving up health: How phytochemicals transform food into medicine in the battle against cancer

Sharma,

Tewari,

Sati

et al. 2024

Food Frontiers

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The escalating global cancer burden underscores the urgent need for more effective therapeutic strategies. Phytochemicals, naturally occurring compounds in plants, have garnered attention for their potential in cancer chemoprevention and chemotherapy. Their ability to modulate molecular mechanisms and influence cell signaling pathways offers a promising avenue for cancer management. This review aims to synthesize current knowledge on phytochemicals’ chemopreventive and chemotherapeutic potential, focusing on their molecular mechanisms of action and impacts on cell signaling pathways involved in cancer. A systematic literature search was conducted across major databases, including PubMed/Medline, Web of Science, Scopus, and Google Scholar. The search strategy uses Medical Subject Headings (MeSH) and free‐text terms using Boolean operators to capture relevant studies. Inclusion criteria targeted original research and reviews on the effects of phytochemicals in cancer, with a specific focus on molecular mechanisms. Phytochemicals, including flavonoids, polyphenols, and terpenoids, demonstrated significant anticancer properties by inducing cell cycle arrest, apoptosis, and autophagy. They modulate critical cell signaling pathways, such as cyclooxygenase‐2, nuclear factor kappa B, and various growth factor‐related pathways, and rectify epigenetic alterations, contributing to their chemopreventive and therapeutic effects. Phytochemicals represent a valuable resource for developing novel cancer prevention and treatment strategies; their actions on molecular mechanisms and cell signaling pathways underscore their potential in cancer prevention and combat. Further research is warranted to translate these findings into clinical applications, optimizing phytochemical‐based interventions for cancer management.

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<p>Gigantol Attenuates the Metastasis of Human Bladder Cancer Cells, Possibly Through Wnt/EMT Signaling</p>

Cited by 18 publications

References 37 publications

Traditional Uses, Phytochemistry, Pharmacology, and Quality Control of Dendrobium officinale Kimura et. Migo

Traditional Uses, Phytochemistry, Pharmacology, and Quality Control of Dendrobium officinale Kimura et. Migo

Betulinic Acid Restricts Human Bladder Cancer Cell Proliferation In Vitro by Inducing Caspase-Dependent Cell Death and Cell Cycle Arrest, and Decreasing Metastatic Potential

Serving up health: How phytochemicals transform food into medicine in the battle against cancer

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