&lt;p&gt;Grip Strength: An Indispensable Biomarker For Older Adults&lt;/p&gt;

Bohannon, Richard W.

doi:10.2147/cia.s194543

Cited by 575 publications

(486 citation statements)

References 144 publications

(160 reference statements)

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“…Physical health status was measured by the presence of multiple chronic diseases, which included cardiovascular disease (CVD), chronic obstructive pulmonary disease (COPD), diabetes and osteoarthritis. The selection of chronic conditions was largely determined by data availability and any significant associations with grip strength or walking speed, as reported by previous studies [10,[27][28][29]. A dichotomous variable was constructed for each variable based on the self-reporting of medical conditions that have previously been diagnosed by a medical doctor or other health professional.…”

Section: Other Covariatesmentioning

confidence: 99%

Extent of aging across education and income subgroups in Thailand: Application of a characteristic-based age approach

2020

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Aim This study aimed to identify differences in physical performance across various socioeconomic groups within an older population and to convert those differences into a common metric to facilitate comparisons of aging speed across socioeconomic subgroups. Methods We employed data from the 2009 National Health Examination Survey of Thailand. Physical performance was assessed using three health characteristics: grip strength, as a measure of upper body strength; walking speed, as a measure of lower body strength; and a combined measure of grip strength and walking speed, to capture the strength of the whole body. Education level and income were used to distinguish socioeconomic subpopulations. We followed a characteristic-based age approach to transform these population characteristics, which were measured in different units, into a common and comparable aging metric, referred to as α − age. Results Physical aging trajectories varied by sex and socioeconomic status. Some education, particularly secondary or higher education levels, was significantly associated with greater physical strength in older age for both men and women, whereas higher income was significantly associated with physical strength only for men. Across the three health characteristics, having a primary education slowed age-related declines by up to 6.3 years among men and 2.8 years among women, whereas being in a higher income group slowed age-related declines by 8.2 years among men and up to 4.9 years among women. Conclusions This study adds new evidence from a developing Asian country regarding the difference in aging speeds across subpopulations associated with different levels of education and income.

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Section: Other Covariatesmentioning

confidence: 99%

Extent of aging across education and income subgroups in Thailand: Application of a characteristic-based age approach

2020

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“…Examples of such characteristics include gait speed in older subjects with hematologic malignancies, being predictive of mortality; 29 the timed up and go test in Parkinson's disease and poststroke subjects, demonstrating higher fall risk and disability; 30 and grip strength in older communitydwelling subjects, reflective of upper extremity strength and function. 31 In our study population, we noted that age $ 65 y was a negative predictor of discharge home and was reflective of greater odds of postdischarge mortality. Thus, when caring for subjects in LTACHs who are older, have a greater comorbidity burden, and are nonambulatory, clinicians should be aware of the higher likelihood of worse outcomes.…”

Section: Discussionmentioning

confidence: 60%

Ambulatory Status Is Associated With Successful Discharge Home in Survivors of Critical Illness

et al. 2020

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BACKGROUND: Survivors of prolonged ICU admissions are bedridden and immobilized for an extended period of time. These patients often are discharged to long-term acute care hospitals (LTACHs) for continued medical care and rehabilitation. Early ambulation has been associated with improved functional outcomes and lower readmission rates in hospitalized patients. The aim of this study was to determine the association between ambulatory status and discharge disposition in survivors of prolonged ICU stays who were admitted to an LTACH. METHODS: We performed a retrospective cohort study of 285 survivors of prolonged ICU stays who were admitted to a university-affiliated LTACH facility from 2010 to 2013. Outcomes of interest included comparing the relationship between ambulatory status and disposition status (ie, home vs acute rehabilitation facility, nursing home, readmission to an ICU, or death). RESULTS: The mean age of our cohort was 59.0 6 15.3 y, with 129 (45%) males, 148 (52%) African-American, 123 (43%) white, and 14 (5%) of subjects other races. Most of these subjects were transferred from a medical ICU (68%). The median ICU and LTACH lengths of stay were 25.5 (13-38.8) d and 34.0 (14-64) d, respectively. Thirty-eight (13.3%) subjects were discharged home, 25 (8.7%) to an acute rehabilitation facility, 70 (24.6%) to a nursing home, 139 (48.8%) were readmitted to an ICU, and 13 (4.6%) died. Of 285 total subjects, 74 (26%) ambulated during physical therapy, while 211 (74%) subjects never ambulated. Of those who ambulated, 24 (32.4%) went home, whereas 14 of 211 (6.6%) subjects who did not ambulate went home (P < .001). CONCLUSIONS: The ability to ambulate was associated with a greater likelihood of being discharged home in survivors of prolonged ICU stays who were admitted to an LTACH. These results suggest that mobility training for survivors of prolonged ICU stays in LTACH facilities should be strongly emphasized to improve their likelihood of being discharged home.

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“…Handgrip strength (HGS) is a simple and reliable tool for measuring body function and has been suggested as a biomarker for older adults [15]. In the past decade, the majority of studies have used the HGS normalized to body weight or body mass index, since has been recommended in the research of muscle health [16,17].…”

Section: Introductionmentioning

confidence: 99%

Glucose Levels as a Mediator of the Detrimental Effect of Abdominal Obesity on Relative Handgrip Strength in Older Adults

Pérez-Sousa

Pozo-Cruz

Cano-Gutiérrez

et al. 2020

JCM

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Excess central adiposity accelerates the decline of muscle strength in older people. Additionally, hyperglycemia, independent of associated comorbidities, is related to the loss of muscle mass and strength, and contributes to functional impairment in older adults. We studied the mediation effect of glucose levels, in the relationship between abdominal obesity and relative handgrip strength (HGS). A total of 1571 participants (60.0% women, mean age 69.1 ± 7.0 years) from 86 municipalities were selected following a multistage area probability sampling design. Measurements included demographic and anthropometric/adiposity markers (weight, height, body mass index, and waist circumference). HGS was measured using a digital dynamometer for three sets and the mean value was recorded. The values were normalized to body weight (relative HGS). Fasting glucose was analyzed by enzymatic colorimetric methods. Mediation analyses were performed to identify associations between the independent variable (abdominal obesity) and outcomes (relative HGS), as well as to determine whether fasting glucose levels mediated the relationship between excess adiposity and relative HGS. A total of 1239 (78.8%) had abdominal obesity. Abdominal obesity had a negative effect on fasting glucose (β = 9.04, 95%CI = 5.87 to 12.21); while fasting glucose to relative HGS was inversely related (β = −0.003, 95%CI = −0.005 to −0.001), p < 0.001. The direct effect of abdominal obesity on relative HGS was statistically significant (β = −0.069, 95%CI = −0.082 to −0.057), p < 0.001. Lastly, fasting glucose levels mediates the detrimental effect of abdominal obesity on relative HGS (indirect effect β = −0.002, 95%CI = −0.004 to −0.001), p < 0.001. Our results suggest that the glucose level could worsen the association between abdominal obesity status and lower HGS. Thus, it is plausible to consider fasting glucose levels when assessing older adults with excess adiposity and/or suspected loss of muscle mass.

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<p>Grip Strength: An Indispensable Biomarker For Older Adults</p>

Cited by 575 publications

References 144 publications

Extent of aging across education and income subgroups in Thailand: Application of a characteristic-based age approach

Extent of aging across education and income subgroups in Thailand: Application of a characteristic-based age approach

Ambulatory Status Is Associated With Successful Discharge Home in Survivors of Critical Illness

Glucose Levels as a Mediator of the Detrimental Effect of Abdominal Obesity on Relative Handgrip Strength in Older Adults

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