2020
DOI: 10.2147/copd.s247446
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<p>Heterozygous Genotype rs17580 AT (PiS) in <em>SERPINA1</em> is Associated with COPD Secondary to Biomass-Burning and Tobacco Smoking: A Case–Control and Populational Study</p>

Abstract: The protease inhibitor S (PiS) and Z (PiZ) variants have been stated as the only genetic cause of chronic obstructive pulmonary disease (COPD) in Caucasians. However, its frequency in admixed populations is low. We aimed to identify genetic susceptibility between PiS (rs17580) and PiZ (rs28929474) polymorphisms with COPD related to tobacco smoking and biomass-burning smoke as well as to determine its frequencies in Mestizo and Amerindian populations from Mexico. Patients and Methods: One thousand and eight hun… Show more

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Cited by 6 publications
(8 citation statements)
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“…This information is particularly relevant in the Mexican cohort of women whose average height is 148 cm, which is notably lower than smokers (men and women) studied by Burrows. In this sense, studies performed in women exposed to biomass showed that genetic susceptibility ( 57 60 ) together with the socioeconomic context may influence growth and decrease lung function, as previously demonstrated by some reports ( 61 63 ).…”
Section: Discussionsupporting
confidence: 54%
“…This information is particularly relevant in the Mexican cohort of women whose average height is 148 cm, which is notably lower than smokers (men and women) studied by Burrows. In this sense, studies performed in women exposed to biomass showed that genetic susceptibility ( 57 60 ) together with the socioeconomic context may influence growth and decrease lung function, as previously demonstrated by some reports ( 61 63 ).…”
Section: Discussionsupporting
confidence: 54%
“…We selected these SNPs because a critical role in the disease has been observed in other populations; however, in biomass-burning smoke-exposed individuals, their participation has not been evaluated to date. In our current study in biomass-burning smoke-exposed women, we found that the rs13118928 GG genotype was associated with a decreased risk (OR = 0.51) of the disease; interestingly, these populations have a higher Amerindian component [ 33 ]. Regarding the analysis by genetic association models (recessive model), it was shown that carrying two copies of the minor allele (GG) also provides a decreased risk of disease.…”
Section: Discussionmentioning
confidence: 99%
“…In a recent study in Mexican-mestizo smokers, we found an association with COPD susceptibility with rs13147758 [ 34 ] but not rs13118928. [ 33 , 34 ].…”
Section: Discussionmentioning
confidence: 99%
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“… 14 , 15 As for lung cancer, a study explored the change of SERPINA1 was associated with worse survival rates in non-small cell lung cancer (NSCLC). 8 However, the methylation levels of SERPINA1 in the male patients with COPD comorbid with LC have not been well studied in detail.…”
Section: Introductionmentioning
confidence: 99%