Ophthalmic treatments using contact lenses are now used by more and more specialists around the world. Improving contact lens (CL) materials is a condition that is constantly evolving. Contact lens materials are usually composed of polymer hydrogel or silicone hydrogel. The materials used for night contact lenses are gas permeable and they gradual flatten the center of the cornea which decreases the progression of myopia or myopic astigmatism. The aim of this study is to identify, in correlation with the chemical interactions between structural components of contact lenses and their biocompatibility with the surface layer and microtopography of the cornea or sclera, different incidents that occur in patients who have used rigid gas permeable contact lenses. The study was performed on a group of 10 patients who had a follow-up period between 4 and 6 years, who presented regularly for eye examinations. The following clinical parameters were analyzed: ocular refraction before and after wearing night contact lenses, types of contact lens materials, appearance of corneal topography, biomicroscopic examination of the anterior segment of the eye, keratometry, ocular comfort, as well as other incidents regarding this type of lenses. Difficulties caused by wearing contact lenses at night arose due to poor hygiene and maintenance in two cases or due to interruption of lens wear in one case.